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Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?

Fava, Cristiano LU ; Ricci, Marco; Melander, Olle LU and Minuz, Pietro (2012) In Prostaglandins & other Lipid Mediators 98(3-4). p.75-85
Abstract
Hypertension is a multifactorial disease in which the interplay of genetic and environmental factors that maintain blood pressure stable throughout life is altered. Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect. Several SNPs, some recognized as functional, in human genes implicated in EETs/20-HETE biosynthesis and metabolism, such as CYP2J2 and CYP4A11, have been tested for association with blood pressure, hypertension and... (More)
Hypertension is a multifactorial disease in which the interplay of genetic and environmental factors that maintain blood pressure stable throughout life is altered. Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect. Several SNPs, some recognized as functional, in human genes implicated in EETs/20-HETE biosynthesis and metabolism, such as CYP2J2 and CYP4A11, have been tested for association with blood pressure, hypertension and its long-term cardiovascular consequences in different populations, with conflicting results. A sex-specific effect, related to CYP4F2 polymorphisms and expression, has been observed in association studies. This finding indicates that altered 20-HETE bioactivity underlay the excess of hypertension and associated vascular events observed in men with respect to women and is consistent with the results from experimental models. Further epidemiological and mechanistic studies are required to confirm the effect of lipid mediators on blood pressure in humans and define the mechanisms of a putative sex-specific effect. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Prostaglandins & other Lipid Mediators
volume
98
issue
3-4
pages
75 - 85
publisher
Elsevier
external identifiers
  • wos:000308120800007
  • pmid:22173545
  • scopus:84864488076
ISSN
1098-8823
DOI
10.1016/j.prostaglandins.2011.11.007
language
English
LU publication?
yes
id
849d425f-87d6-4cbb-9071-df8dc26ec744 (old id 2273985)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22173545?dopt=Abstract
date added to LUP
2012-01-03 19:55:36
date last changed
2017-10-22 04:26:30
@article{849d425f-87d6-4cbb-9071-df8dc26ec744,
  abstract     = {Hypertension is a multifactorial disease in which the interplay of genetic and environmental factors that maintain blood pressure stable throughout life is altered. Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect. Several SNPs, some recognized as functional, in human genes implicated in EETs/20-HETE biosynthesis and metabolism, such as CYP2J2 and CYP4A11, have been tested for association with blood pressure, hypertension and its long-term cardiovascular consequences in different populations, with conflicting results. A sex-specific effect, related to CYP4F2 polymorphisms and expression, has been observed in association studies. This finding indicates that altered 20-HETE bioactivity underlay the excess of hypertension and associated vascular events observed in men with respect to women and is consistent with the results from experimental models. Further epidemiological and mechanistic studies are required to confirm the effect of lipid mediators on blood pressure in humans and define the mechanisms of a putative sex-specific effect.},
  author       = {Fava, Cristiano and Ricci, Marco and Melander, Olle and Minuz, Pietro},
  issn         = {1098-8823},
  language     = {eng},
  number       = {3-4},
  pages        = {75--85},
  publisher    = {Elsevier},
  series       = {Prostaglandins & other Lipid Mediators},
  title        = {Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?},
  url          = {http://dx.doi.org/10.1016/j.prostaglandins.2011.11.007},
  volume       = {98},
  year         = {2012},
}