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Formation of macroporous self-assembled hydrogels through cryogelation of Fmoc-Phe-Phe.

Berillo, Dmitry LU ; Mattiasson, Bo LU ; Galaev, Igor LU and Kirsebom, Harald LU (2012) In Journal of Colloid and Interface Science 368(1). p.226-230
Abstract
In this study, it was found that macroporous hydrogels were formed when self-assembly of fluorenyl-9-methoxycarbonyl (Fmoc)-diphenylalanine (Phe-Phe) peptides was induced using glucono-δ-lactone (GdL) in apparently frozen samples. Formed cryogels exhibited a heterogeneous structure with pore walls of densely packed fibres of assembled dipeptides and pores in the range 10-100μm. Hydrogels formed from the same composition above the freezing point exhibited a homogenous structure without any apparent porosity. The formed gels were characterised using microscopy techniques, CD-spectroscopy and stress sweeps. The cryogels exhibited less mechanical strength than the hydrogels that might be due to the heterogeneous structure of the former. It... (More)
In this study, it was found that macroporous hydrogels were formed when self-assembly of fluorenyl-9-methoxycarbonyl (Fmoc)-diphenylalanine (Phe-Phe) peptides was induced using glucono-δ-lactone (GdL) in apparently frozen samples. Formed cryogels exhibited a heterogeneous structure with pore walls of densely packed fibres of assembled dipeptides and pores in the range 10-100μm. Hydrogels formed from the same composition above the freezing point exhibited a homogenous structure without any apparent porosity. The formed gels were characterised using microscopy techniques, CD-spectroscopy and stress sweeps. The cryogels exhibited less mechanical strength than the hydrogels that might be due to the heterogeneous structure of the former. It appeared that the self-assembled peptide both in the cryo- and hydrogel maintained the β-sheet structure commonly attributed to these. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Colloid and Interface Science
volume
368
issue
1
pages
226 - 230
publisher
Elsevier
external identifiers
  • wos:000299490500029
  • pmid:22129632
  • scopus:84855861204
ISSN
1095-7103
DOI
10.1016/j.jcis.2011.11.006
language
English
LU publication?
yes
id
fd33f35e-6736-437b-8abe-0c76766969b8 (old id 2274741)
date added to LUP
2012-01-12 17:27:48
date last changed
2017-08-27 03:24:32
@article{fd33f35e-6736-437b-8abe-0c76766969b8,
  abstract     = {In this study, it was found that macroporous hydrogels were formed when self-assembly of fluorenyl-9-methoxycarbonyl (Fmoc)-diphenylalanine (Phe-Phe) peptides was induced using glucono-δ-lactone (GdL) in apparently frozen samples. Formed cryogels exhibited a heterogeneous structure with pore walls of densely packed fibres of assembled dipeptides and pores in the range 10-100μm. Hydrogels formed from the same composition above the freezing point exhibited a homogenous structure without any apparent porosity. The formed gels were characterised using microscopy techniques, CD-spectroscopy and stress sweeps. The cryogels exhibited less mechanical strength than the hydrogels that might be due to the heterogeneous structure of the former. It appeared that the self-assembled peptide both in the cryo- and hydrogel maintained the β-sheet structure commonly attributed to these.},
  author       = {Berillo, Dmitry and Mattiasson, Bo and Galaev, Igor and Kirsebom, Harald},
  issn         = {1095-7103},
  language     = {eng},
  number       = {1},
  pages        = {226--230},
  publisher    = {Elsevier},
  series       = {Journal of Colloid and Interface Science},
  title        = {Formation of macroporous self-assembled hydrogels through cryogelation of Fmoc-Phe-Phe.},
  url          = {http://dx.doi.org/10.1016/j.jcis.2011.11.006},
  volume       = {368},
  year         = {2012},
}