Advanced

Relationship of 3D meniscal morphology and position with knee pain in subjects with knee osteoarthritis: a pilot study

Wenger, Andrea; Englund, Martin LU ; Wirth, Wolfgang; Hudelmaier, Martin; Kwoh, Kent and Eckstein, Felix (2012) In European Radiology 22(1). p.211-220
Abstract
To explore whether quantitative, three-dimensional measurements of meniscal position and size are associated with knee pain using a within-person, between-knee study design. We studied 53 subjects (19 men, 34 women) from the Osteoarthritis Initiative, with identical radiographic OA grades in both knees, but frequent pain in one and no pain in the other knee. The tibial plateau and menisci were analyzed using coronally reconstructed double echo steady-state sequence with water excitation (DESSwe) MRI. The medial meniscus covered a smaller proportion of the tibial plateau (-5%) and displayed greater extrusion of the body (+15%) in painful than in painless knees (paired t-test; p < 0.05). The external margin of the lateral meniscus showed... (More)
To explore whether quantitative, three-dimensional measurements of meniscal position and size are associated with knee pain using a within-person, between-knee study design. We studied 53 subjects (19 men, 34 women) from the Osteoarthritis Initiative, with identical radiographic OA grades in both knees, but frequent pain in one and no pain in the other knee. The tibial plateau and menisci were analyzed using coronally reconstructed double echo steady-state sequence with water excitation (DESSwe) MRI. The medial meniscus covered a smaller proportion of the tibial plateau (-5%) and displayed greater extrusion of the body (+15%) in painful than in painless knees (paired t-test; p < 0.05). The external margin of the lateral meniscus showed greater extrusion of the body in painful knees (+22%; p = 0.03), but no significant difference in the position of its internal margin or tibial coverage. Medial or lateral extrusion a parts per thousand yen3 mm was more frequent in painful (n = 23) than in painless knees (n = 12; McNemar's test; p = 0.02). No significant association was observed between meniscal size and knee pain. These data suggest a relationship between extrusion of the meniscal body, as measured with quantitative MRI, and knee pain in subjects with knee OA. Further studies need to confirm these findings and their clinical relevance. Meniscal segmentation provides quantitative measures of meniscal size/position Between-knee, within-person approaches can explore potential sources of knee pain Meniscal extrusion may be a potential source of knee pain. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Meniscus, Extrusion, Pain, Knee osteoarthritis, Magnetic resonance, imaging
in
European Radiology
volume
22
issue
1
pages
211 - 220
publisher
Springer
external identifiers
  • wos:000297749100022
  • scopus:84857041244
ISSN
0938-7994
DOI
10.1007/s00330-011-2234-z
language
English
LU publication?
yes
id
e0f4872b-c052-4e9c-b211-512df356defd (old id 2278978)
date added to LUP
2012-01-11 13:48:02
date last changed
2017-11-12 03:07:25
@article{e0f4872b-c052-4e9c-b211-512df356defd,
  abstract     = {To explore whether quantitative, three-dimensional measurements of meniscal position and size are associated with knee pain using a within-person, between-knee study design. We studied 53 subjects (19 men, 34 women) from the Osteoarthritis Initiative, with identical radiographic OA grades in both knees, but frequent pain in one and no pain in the other knee. The tibial plateau and menisci were analyzed using coronally reconstructed double echo steady-state sequence with water excitation (DESSwe) MRI. The medial meniscus covered a smaller proportion of the tibial plateau (-5%) and displayed greater extrusion of the body (+15%) in painful than in painless knees (paired t-test; p &lt; 0.05). The external margin of the lateral meniscus showed greater extrusion of the body in painful knees (+22%; p = 0.03), but no significant difference in the position of its internal margin or tibial coverage. Medial or lateral extrusion a parts per thousand yen3 mm was more frequent in painful (n = 23) than in painless knees (n = 12; McNemar's test; p = 0.02). No significant association was observed between meniscal size and knee pain. These data suggest a relationship between extrusion of the meniscal body, as measured with quantitative MRI, and knee pain in subjects with knee OA. Further studies need to confirm these findings and their clinical relevance. Meniscal segmentation provides quantitative measures of meniscal size/position Between-knee, within-person approaches can explore potential sources of knee pain Meniscal extrusion may be a potential source of knee pain.},
  author       = {Wenger, Andrea and Englund, Martin and Wirth, Wolfgang and Hudelmaier, Martin and Kwoh, Kent and Eckstein, Felix},
  issn         = {0938-7994},
  keyword      = {Meniscus,Extrusion,Pain,Knee osteoarthritis,Magnetic resonance,imaging},
  language     = {eng},
  number       = {1},
  pages        = {211--220},
  publisher    = {Springer},
  series       = {European Radiology},
  title        = {Relationship of 3D meniscal morphology and position with knee pain in subjects with knee osteoarthritis: a pilot study},
  url          = {http://dx.doi.org/10.1007/s00330-011-2234-z},
  volume       = {22},
  year         = {2012},
}