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Pesticide exposure in farming and forestry and the risk of uveal melanoma

Behrens, Thomas; Lynge, Elsebeth; Cree, Ian; Lutz, Jean-Michel; Eriksson, Mikael LU ; Guenel, Pascal; Merletti, Franco; Morales-Suarez-Varela, Maria; Afonso, Noemia and Stengrevics, Aivars, et al. (2012) In Cancer Causes and Control 23(1). p.141-151
Abstract
Since pesticides are disputed risk factors for uveal melanoma, we studied the association between occupational pesticide exposure and uveal melanoma risk in a case-control study from nine European countries. Incident cases of uveal melanoma and population as well as hospital controls were included and frequency-matched by country, 5-year age groups and sex. Self-reported exposure was quantified with respect to duration of exposure and pesticide application method. We calculated the exposure intensity level based on application method and use of personal protective equipment. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by unconditional logistic regression analyses and adjusted for several potential confounders. 293... (More)
Since pesticides are disputed risk factors for uveal melanoma, we studied the association between occupational pesticide exposure and uveal melanoma risk in a case-control study from nine European countries. Incident cases of uveal melanoma and population as well as hospital controls were included and frequency-matched by country, 5-year age groups and sex. Self-reported exposure was quantified with respect to duration of exposure and pesticide application method. We calculated the exposure intensity level based on application method and use of personal protective equipment. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by unconditional logistic regression analyses and adjusted for several potential confounders. 293 case and 3,198 control subjects were interviewed. We did not identify positive associations with activities in farming or forestry, pesticide application or pesticide mixing. No consistent positive associations were seen with exposure intensity level scores either. The only statistically significantly raised association in this study was for exposure to chemical fertilizers in forestry (OR = 8.93; 95% CI 1.73-42.13), but this observation was based on only six exposed subjects. Results did not change when we restricted analyses to morphologically verified cases and excluded proxy interviews as well as cancer controls. We did not observe effect modification by sex or eye color. Risk estimates for pesticide exposures and occupational activities in agriculture and forestry were not increased and did not indicate a hormonal mechanism due to these exposures. (Less)
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publication status
published
subject
keywords
Agriculture, Animal husbandry, Chemical fertilizers, Multicenter study, Ocular melanoma
in
Cancer Causes and Control
volume
23
issue
1
pages
141 - 151
publisher
Springer
external identifiers
  • wos:000297757400014
  • scopus:82955195606
ISSN
1573-7225
DOI
10.1007/s10552-011-9863-z
language
English
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yes
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f80aafb1-9339-4e53-916e-c9111440a952 (old id 2278986)
date added to LUP
2012-01-11 13:51:35
date last changed
2017-09-10 03:01:29
@article{f80aafb1-9339-4e53-916e-c9111440a952,
  abstract     = {Since pesticides are disputed risk factors for uveal melanoma, we studied the association between occupational pesticide exposure and uveal melanoma risk in a case-control study from nine European countries. Incident cases of uveal melanoma and population as well as hospital controls were included and frequency-matched by country, 5-year age groups and sex. Self-reported exposure was quantified with respect to duration of exposure and pesticide application method. We calculated the exposure intensity level based on application method and use of personal protective equipment. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by unconditional logistic regression analyses and adjusted for several potential confounders. 293 case and 3,198 control subjects were interviewed. We did not identify positive associations with activities in farming or forestry, pesticide application or pesticide mixing. No consistent positive associations were seen with exposure intensity level scores either. The only statistically significantly raised association in this study was for exposure to chemical fertilizers in forestry (OR = 8.93; 95% CI 1.73-42.13), but this observation was based on only six exposed subjects. Results did not change when we restricted analyses to morphologically verified cases and excluded proxy interviews as well as cancer controls. We did not observe effect modification by sex or eye color. Risk estimates for pesticide exposures and occupational activities in agriculture and forestry were not increased and did not indicate a hormonal mechanism due to these exposures.},
  author       = {Behrens, Thomas and Lynge, Elsebeth and Cree, Ian and Lutz, Jean-Michel and Eriksson, Mikael and Guenel, Pascal and Merletti, Franco and Morales-Suarez-Varela, Maria and Afonso, Noemia and Stengrevics, Aivars and Fevotte, Joelle and Sabroe, Svend and Llopis-Gonzalez, Agustin and Gorini, Giuseppe and Hardell, Lennart and Stang, Andreas and Ahrens, Wolfgang},
  issn         = {1573-7225},
  keyword      = {Agriculture,Animal husbandry,Chemical fertilizers,Multicenter study,Ocular melanoma},
  language     = {eng},
  number       = {1},
  pages        = {141--151},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Pesticide exposure in farming and forestry and the risk of uveal melanoma},
  url          = {http://dx.doi.org/10.1007/s10552-011-9863-z},
  volume       = {23},
  year         = {2012},
}