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Depressive Symptoms, Antidepressant Medication Use, and Insulin Resistance The PPP-Botnia Study

Pyykkonen, Antti-Jussi; Raikkonen, Katri; Tuomi, Tiinamaija; Eriksson, Johan G.; Groop, Leif LU and Isomaa, Bo (2011) In Diabetes Care 34(12). p.2545-2547
Abstract
OBJECTIVE-Although insulin resistance (IR) may underlie associations between depressive symptoms and diabetes, previous findings have been contradictory. We examined whether depressive symptoms associate with IR and insulin secretion, and, additionally, whether antidepressant medication use may modulate such associations. RESEARCH DESIGN AND METHODS-A total of 4,419 individuals underwent an oral glucose tolerance test (OGTT). Participants with previously or newly diagnosed diabetes are excluded from this sample. The homeostasis model assessment of IR (HOMA-IR) and corrected insulin response (CIR) were calculated. Depressive symptoms and antidepressant medication use were self-reported. RESULTS-After controlling for confounding factors,... (More)
OBJECTIVE-Although insulin resistance (IR) may underlie associations between depressive symptoms and diabetes, previous findings have been contradictory. We examined whether depressive symptoms associate with IR and insulin secretion, and, additionally, whether antidepressant medication use may modulate such associations. RESEARCH DESIGN AND METHODS-A total of 4,419 individuals underwent an oral glucose tolerance test (OGTT). Participants with previously or newly diagnosed diabetes are excluded from this sample. The homeostasis model assessment of IR (HOMA-IR) and corrected insulin response (CIR) were calculated. Depressive symptoms and antidepressant medication use were self-reported. RESULTS-After controlling for confounding factors, depressive symptoms were associated with higher fasting and 30-mM insulin during the OGTT and higher HOMA-IR but not CIR. Antidepressant medication use failed to modify these associations. CONCLUSIONS-Depressive symptoms are associated with IR but not with changes in insulin response when corrected for IR in individuals without previously or newly diagnosed diabetes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
34
issue
12
pages
2545 - 2547
publisher
American Diabetes Association
external identifiers
  • wos:000298122900012
  • scopus:84860846515
ISSN
1935-5548
DOI
10.2337/dc11-0107
language
English
LU publication?
yes
id
1c6f2f18-3386-4cab-840e-69bfdf1e2c51 (old id 2279318)
date added to LUP
2012-01-11 15:24:55
date last changed
2017-08-20 04:11:42
@article{1c6f2f18-3386-4cab-840e-69bfdf1e2c51,
  abstract     = {OBJECTIVE-Although insulin resistance (IR) may underlie associations between depressive symptoms and diabetes, previous findings have been contradictory. We examined whether depressive symptoms associate with IR and insulin secretion, and, additionally, whether antidepressant medication use may modulate such associations. RESEARCH DESIGN AND METHODS-A total of 4,419 individuals underwent an oral glucose tolerance test (OGTT). Participants with previously or newly diagnosed diabetes are excluded from this sample. The homeostasis model assessment of IR (HOMA-IR) and corrected insulin response (CIR) were calculated. Depressive symptoms and antidepressant medication use were self-reported. RESULTS-After controlling for confounding factors, depressive symptoms were associated with higher fasting and 30-mM insulin during the OGTT and higher HOMA-IR but not CIR. Antidepressant medication use failed to modify these associations. CONCLUSIONS-Depressive symptoms are associated with IR but not with changes in insulin response when corrected for IR in individuals without previously or newly diagnosed diabetes.},
  author       = {Pyykkonen, Antti-Jussi and Raikkonen, Katri and Tuomi, Tiinamaija and Eriksson, Johan G. and Groop, Leif and Isomaa, Bo},
  issn         = {1935-5548},
  language     = {eng},
  number       = {12},
  pages        = {2545--2547},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Depressive Symptoms, Antidepressant Medication Use, and Insulin Resistance The PPP-Botnia Study},
  url          = {http://dx.doi.org/10.2337/dc11-0107},
  volume       = {34},
  year         = {2011},
}