Advanced

Gray-scale and color Doppler ultrasound characteristics of endometrial cancer in relation to stage, grade and tumor size

Epstein, E.; Van Holsbeke, C.; Mascilini, F.; Måsbäck, Anna LU ; Kannisto, Päivi LU ; Ameye, L.; Fischerova, D.; Zannoni, G.; Vellone, V. and Timmerman, D., et al. (2011) In Ultrasound in Obstetrics & Gynecology 38(5). p.586-593
Abstract
Objectives To describe the gray-scale and vascular characteristics of endometrial cancer in relation to stage, grade and size using two-dimensional (2D)/three-dimensional (3D) transvaginal ultrasound. Methods This was a prospective multicenter study including 144 women with endometrial cancer undergoing transvaginal ultrasound before surgery. The sonographic characteristics assessed were echogenicity, endometrial/myometrial border, fibroids, vascular pattern, color score and tumor/uterus anteroposterior (AP) ratio. Histological assessment of tumor stage, grade, type and growth pattern was performed. Results Hyperechoic or isoechoic tumors were more often seen in Stage IA cancer, whereas mixed or hypoechoic tumors were more often found in... (More)
Objectives To describe the gray-scale and vascular characteristics of endometrial cancer in relation to stage, grade and size using two-dimensional (2D)/three-dimensional (3D) transvaginal ultrasound. Methods This was a prospective multicenter study including 144 women with endometrial cancer undergoing transvaginal ultrasound before surgery. The sonographic characteristics assessed were echogenicity, endometrial/myometrial border, fibroids, vascular pattern, color score and tumor/uterus anteroposterior (AP) ratio. Histological assessment of tumor stage, grade, type and growth pattern was performed. Results Hyperechoic or isoechoic tumors were more often seen in Stage IA cancer, whereas mixed or hypoechoic tumors were more often found in cancers of Stage IB or greater (P = 0.003). Hyperechogenicity was more common in Grade 1-2 tumors (i.e. well or moderately differentiated) (P = 0.02) and in tumors with a tumor/uterine AP ratio of <50% (P = 0.002), whereas a non-hyperechoic appearance was more commonly found in Grade 3 tumors (i.e. poorly differentiated) and in tumors with a tumor/uterine AP ratio of >= 50%. Multiple global vessels were more often seen in tumors of Stage IB or greater than in Stage IA tumors (P = 0.02), in Grade 3 tumors than in Grade 1 and 2 tumors (P = 0.02) and in tumors with a tumor/uterine AP ratio of >= 50% (P < 0.001). A moderate/high color score was significantly more common in tumors of higher stage (P = 0.03) and larger size (P = 0.001). Conclusion The sonographic appearance of endometrial cancer is significantly associated with tumor stage, grade and size. More advanced tumors often have a mixed/hypoechoic echogenicity, a higher color score and multiple globally entering vessels, whereas less advanced tumors are more often hyperechoic and have no or a low color score. Copyright (C) 2011 ISUOG. Published by John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Doppler ultrasound, endometrial cancer, sonomorphology, transvaginal, ultrasound
in
Ultrasound in Obstetrics & Gynecology
volume
38
issue
5
pages
586 - 593
publisher
John Wiley & Sons
external identifiers
  • wos:000297512300018
  • scopus:84855737004
ISSN
1469-0705
DOI
10.1002/uog.9038
language
English
LU publication?
yes
id
1ab8ff4a-cb11-490c-9a7e-9029bad7ce88 (old id 2279340)
date added to LUP
2012-01-11 15:28:20
date last changed
2017-08-27 04:51:19
@article{1ab8ff4a-cb11-490c-9a7e-9029bad7ce88,
  abstract     = {Objectives To describe the gray-scale and vascular characteristics of endometrial cancer in relation to stage, grade and size using two-dimensional (2D)/three-dimensional (3D) transvaginal ultrasound. Methods This was a prospective multicenter study including 144 women with endometrial cancer undergoing transvaginal ultrasound before surgery. The sonographic characteristics assessed were echogenicity, endometrial/myometrial border, fibroids, vascular pattern, color score and tumor/uterus anteroposterior (AP) ratio. Histological assessment of tumor stage, grade, type and growth pattern was performed. Results Hyperechoic or isoechoic tumors were more often seen in Stage IA cancer, whereas mixed or hypoechoic tumors were more often found in cancers of Stage IB or greater (P = 0.003). Hyperechogenicity was more common in Grade 1-2 tumors (i.e. well or moderately differentiated) (P = 0.02) and in tumors with a tumor/uterine AP ratio of &lt;50% (P = 0.002), whereas a non-hyperechoic appearance was more commonly found in Grade 3 tumors (i.e. poorly differentiated) and in tumors with a tumor/uterine AP ratio of &gt;= 50%. Multiple global vessels were more often seen in tumors of Stage IB or greater than in Stage IA tumors (P = 0.02), in Grade 3 tumors than in Grade 1 and 2 tumors (P = 0.02) and in tumors with a tumor/uterine AP ratio of &gt;= 50% (P &lt; 0.001). A moderate/high color score was significantly more common in tumors of higher stage (P = 0.03) and larger size (P = 0.001). Conclusion The sonographic appearance of endometrial cancer is significantly associated with tumor stage, grade and size. More advanced tumors often have a mixed/hypoechoic echogenicity, a higher color score and multiple globally entering vessels, whereas less advanced tumors are more often hyperechoic and have no or a low color score. Copyright (C) 2011 ISUOG. Published by John Wiley &amp; Sons, Ltd.},
  author       = {Epstein, E. and Van Holsbeke, C. and Mascilini, F. and Måsbäck, Anna and Kannisto, Päivi and Ameye, L. and Fischerova, D. and Zannoni, G. and Vellone, V. and Timmerman, D. and Testa, A. C.},
  issn         = {1469-0705},
  keyword      = {Doppler ultrasound,endometrial cancer,sonomorphology,transvaginal,ultrasound},
  language     = {eng},
  number       = {5},
  pages        = {586--593},
  publisher    = {John Wiley & Sons},
  series       = {Ultrasound in Obstetrics & Gynecology},
  title        = {Gray-scale and color Doppler ultrasound characteristics of endometrial cancer in relation to stage, grade and tumor size},
  url          = {http://dx.doi.org/10.1002/uog.9038},
  volume       = {38},
  year         = {2011},
}