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Developmental adaptation of rat nociceptive withdrawal reflexes after neonatal tendon transfer

Holmberg, H ; Schouenborg, Jens LU ; Yu, Y and Weng, H-R (1997) In JNeurosci 17(6). p.2071-2078
Abstract
Nociceptive withdrawal reflexes (NWRs) were studied in adult rats in which the movement patterns produced by single muscles had been altered by neonatal tendon transfer. NWRs evoked by cutaneous noxious mechanical and thermal (CO2-laser) stimulation were recorded using electromyography in a decerebrate spinal preparation. The sensitivity distribution within the receptive fields of the NWRs of the extensor digitorum longus and the peronei muscles exhibited changes corresponding to the altered movement patterns. No detectable change of NWRs was found in normal muscles whose receptive fields overlapped that of the modified muscle. Furthermore, NWRs of muscles that regained an essentially normal function after neonatal tendon transfer did not... (More)
Nociceptive withdrawal reflexes (NWRs) were studied in adult rats in which the movement patterns produced by single muscles had been altered by neonatal tendon transfer. NWRs evoked by cutaneous noxious mechanical and thermal (CO2-laser) stimulation were recorded using electromyography in a decerebrate spinal preparation. The sensitivity distribution within the receptive fields of the NWRs of the extensor digitorum longus and the peronei muscles exhibited changes corresponding to the altered movement patterns. No detectable change of NWRs was found in normal muscles whose receptive fields overlapped that of the modified muscle. Furthermore, NWRs of muscles that regained an essentially normal function after neonatal tendon transfer did not differ from normal. It is proposed that a developmental experience-dependent mechanism, which takes into account the hindlimb movement pattern caused by contraction of single muscles, underlies the functionally adapted organization of adult NWRs. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
JNeurosci
volume
17
issue
6
pages
2071 - 2078
publisher
Society for Neuroscience
external identifiers
  • scopus:0031030074
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.17-06-02071.1997
language
English
LU publication?
yes
id
227bb01b-ee49-4517-bc2d-8321dd4d18ca
date added to LUP
2019-06-24 15:55:42
date last changed
2023-09-09 08:16:14
@article{227bb01b-ee49-4517-bc2d-8321dd4d18ca,
  abstract     = {{Nociceptive withdrawal reflexes (NWRs) were studied in adult rats in which the movement patterns produced by single muscles had been altered by neonatal tendon transfer. NWRs evoked by cutaneous noxious mechanical and thermal (CO2-laser) stimulation were recorded using electromyography in a decerebrate spinal preparation. The sensitivity distribution within the receptive fields of the NWRs of the extensor digitorum longus and the peronei muscles exhibited changes corresponding to the altered movement patterns. No detectable change of NWRs was found in normal muscles whose receptive fields overlapped that of the modified muscle. Furthermore, NWRs of muscles that regained an essentially normal function after neonatal tendon transfer did not differ from normal. It is proposed that a developmental experience-dependent mechanism, which takes into account the hindlimb movement pattern caused by contraction of single muscles, underlies the functionally adapted organization of adult NWRs.}},
  author       = {{Holmberg, H and Schouenborg, Jens and Yu, Y and Weng, H-R}},
  issn         = {{1529-2401}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{2071--2078}},
  publisher    = {{Society for Neuroscience}},
  series       = {{JNeurosci}},
  title        = {{Developmental adaptation of rat nociceptive withdrawal reflexes after neonatal tendon transfer}},
  url          = {{http://dx.doi.org/10.1523/JNEUROSCI.17-06-02071.1997}},
  doi          = {{10.1523/JNEUROSCI.17-06-02071.1997}},
  volume       = {{17}},
  year         = {{1997}},
}