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Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMDa of the hip and spine in middle-aged and elderly European men: the European Male Ageing Study (EMAS)

Boonen, Steven; Pye, Stephen R.; O'Neill, Terence W.; Szulc, Pawel; Gielen, Evelien; Borghs, Herman; Verschueren, Sabine; Claessens, Frank; Adams, Judith E. and Award, Kate, et al. (2011) In European Journal of Endocrinology 165(6). p.977-986
Abstract
Objective: To assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men. Design: A cross-sectional population-based survey. Methods: Men aged 40-79 years were recruited from population registers in eight European centres. Subjects completed a postal questionnaire which included questions concerning lifestyle and were invited to undergo quantitative ultrasound (QUS) of the calcaneus and to provide a fasting blood sample from which the bone markers serum N-terminal propeptide of type 1 procollagen (P1NP) and crosslinks (beta C-terminal cross-linked telopeptide (beta-cTX)), total testosterone, total oestradiol (E-2), sex... (More)
Objective: To assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men. Design: A cross-sectional population-based survey. Methods: Men aged 40-79 years were recruited from population registers in eight European centres. Subjects completed a postal questionnaire which included questions concerning lifestyle and were invited to undergo quantitative ultrasound (QUS) of the calcaneus and to provide a fasting blood sample from which the bone markers serum N-terminal propeptide of type 1 procollagen (P1NP) and crosslinks (beta C-terminal cross-linked telopeptide (beta-cTX)), total testosterone, total oestradiol (E-2), sex hormone-binding globulin (SHBG) and insulin-like growth factor 1 (IGF1) were measured. Dualenergy X-ray absorptiometry (DXA) of the hip and lumbar spine was performed in two centres. Results: A total of 3120, mean age 59.9 years (S.D. = 11.0) were included. After adjustment for centre, age, height, weight, lifestyle factors, season and other hormones, total and free E-2 were negatively associated with beta-cTX but not P1NP while SHBG, IGF1 and parathyroid hormone (PTH) were positively associated with both beta-cTX and P1NP. Total or free testosterone was not independently associated with either bone marker. After the same adjustments, higher levels of both bone markers were significantly associated with lower QUS parameters and lower DXA-assessed bone density at the total hip and lumbar spine. Conclusions: E-2, SHBG, IGF1 and PTH contribute significantly to the regulation/rate of bone turnover in middle-aged and older European men. Higher rates of bone remodelling are negatively associated with male bone health. (Less)
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European Journal of Endocrinology
volume
165
issue
6
pages
977 - 986
publisher
Society of the European Journal of Endocrinology
external identifiers
  • wos:000297687900017
  • scopus:81555195436
ISSN
1479-683X
DOI
10.1530/EJE-11-0353
language
English
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yes
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46f08207-1a68-4b3b-a8fe-07352dc44836 (old id 2291860)
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2012-01-11 16:36:43
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2017-02-19 03:13:27
@article{46f08207-1a68-4b3b-a8fe-07352dc44836,
  abstract     = {Objective: To assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men. Design: A cross-sectional population-based survey. Methods: Men aged 40-79 years were recruited from population registers in eight European centres. Subjects completed a postal questionnaire which included questions concerning lifestyle and were invited to undergo quantitative ultrasound (QUS) of the calcaneus and to provide a fasting blood sample from which the bone markers serum N-terminal propeptide of type 1 procollagen (P1NP) and crosslinks (beta C-terminal cross-linked telopeptide (beta-cTX)), total testosterone, total oestradiol (E-2), sex hormone-binding globulin (SHBG) and insulin-like growth factor 1 (IGF1) were measured. Dualenergy X-ray absorptiometry (DXA) of the hip and lumbar spine was performed in two centres. Results: A total of 3120, mean age 59.9 years (S.D. = 11.0) were included. After adjustment for centre, age, height, weight, lifestyle factors, season and other hormones, total and free E-2 were negatively associated with beta-cTX but not P1NP while SHBG, IGF1 and parathyroid hormone (PTH) were positively associated with both beta-cTX and P1NP. Total or free testosterone was not independently associated with either bone marker. After the same adjustments, higher levels of both bone markers were significantly associated with lower QUS parameters and lower DXA-assessed bone density at the total hip and lumbar spine. Conclusions: E-2, SHBG, IGF1 and PTH contribute significantly to the regulation/rate of bone turnover in middle-aged and older European men. Higher rates of bone remodelling are negatively associated with male bone health.},
  author       = {Boonen, Steven and Pye, Stephen R. and O'Neill, Terence W. and Szulc, Pawel and Gielen, Evelien and Borghs, Herman and Verschueren, Sabine and Claessens, Frank and Adams, Judith E. and Award, Kate and Bartfai, Gyorgy and Casanueva, Felipe and Finn, Joseph D. and Forti, Gianni and Giwercman, Aleksander and Han, Thang S. and Huhtaniemi, Ilpo T. and Kula, Krzysztof and Labrie, Fernand and Lean, Michael E. J. and Pendleton, Neil and Punab, Margus and Silman, Alan J. and Tajar, Abdelouahid and Wu, Frederick C. W. and Vanderschueren, Dirk},
  issn         = {1479-683X},
  language     = {eng},
  number       = {6},
  pages        = {977--986},
  publisher    = {Society of the European Journal of Endocrinology},
  series       = {European Journal of Endocrinology},
  title        = {Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMDa of the hip and spine in middle-aged and elderly European men: the European Male Ageing Study (EMAS)},
  url          = {http://dx.doi.org/10.1530/EJE-11-0353},
  volume       = {165},
  year         = {2011},
}