Advanced

Swedish Lung Cancer Radiation Study Group: Predictive value of histology for radiotherapy response in patients with non-small cell lung cancer

Holgersson, Georg; Bergstrom, Stefan; Bergqvist, Michael; Nyman, Jan; Hoye, Even; Helsing, Martin; Friesland, Signe; Holgersson, Margareta; Birath, Elisabet and Ekrnan, Simon, et al. (2011) In European Journal of Cancer 47(16). p.2415-2421
Abstract
The aim of the present study was to evaluate the potential predictive value of histology in non-small cell lung cancer (NSCLC) treated with curatively intended radiotherapy. In a collaborative effort among all the Swedish Oncology Departments, clinical data were collected for 1146 patients with a diagnosed non-small cell lung cancer subjected to curatively intended irradiation (>= 50 Gy) during the years 1990 to 2000. The included patients were identified based on a manual search of all medical and radiation charts at the oncology departments from which the individual patient data were collected. Only patients who did not have a histological diagnosis date and death date/last follow-up date were excluded (n = 141). Among the 1146... (More)
The aim of the present study was to evaluate the potential predictive value of histology in non-small cell lung cancer (NSCLC) treated with curatively intended radiotherapy. In a collaborative effort among all the Swedish Oncology Departments, clinical data were collected for 1146 patients with a diagnosed non-small cell lung cancer subjected to curatively intended irradiation (>= 50 Gy) during the years 1990 to 2000. The included patients were identified based on a manual search of all medical and radiation charts at the oncology departments from which the individual patient data were collected. Only patients who did not have a histological diagnosis date and death date/last follow-up date were excluded (n = 141). Among the 1146 patients with non-small cell carcinoma eligible for analysis, 919 were diagnosed with either adenocarcinoma (n = 323) or squamous cell carcinoma (n = 596) and included in this study. The median survival for the 919 patients was 14.8 months, while the 5-year survival rate was 9.5%. Patients with adenocarcinoma had a significantly better overall survival compared with patients with squamous cell carcinoma (p = 0.0062, log-rank test). When comparing different stages, this survival benefit was most pronounced for stages IIA-IIB (p<0.0001, log-rank test). The difference in survival between the two histological groups was statistically significant in a univariate Cox analysis (p = 0.0063) as well as in two multivariate Cox analyses including demographic and treatment variables (p = 0.037 and p = 0.048, respectively). In this large population based retrospective study we describe for the first time that patients with adenocarcinoma have a better survival after curatively intended radiation therapy in comparison with squamous cell carcinoma patients, particularly those with clinical stages IIA-IIB. (C) 2011 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Lung cancer, Non-small cell lung cancer, Histology, Predictive value, Adenocarcinoma, Squamous cell carcinoma
in
European Journal of Cancer
volume
47
issue
16
pages
2415 - 2421
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000297452000007
  • scopus:80054909389
ISSN
1879-0852
DOI
10.1016/j.ejca.2011.06.011
language
English
LU publication?
yes
id
14241dfb-cd0c-4013-a30b-4970b16cee06 (old id 2291888)
date added to LUP
2012-01-11 16:42:03
date last changed
2017-01-01 03:33:17
@article{14241dfb-cd0c-4013-a30b-4970b16cee06,
  abstract     = {The aim of the present study was to evaluate the potential predictive value of histology in non-small cell lung cancer (NSCLC) treated with curatively intended radiotherapy. In a collaborative effort among all the Swedish Oncology Departments, clinical data were collected for 1146 patients with a diagnosed non-small cell lung cancer subjected to curatively intended irradiation (&gt;= 50 Gy) during the years 1990 to 2000. The included patients were identified based on a manual search of all medical and radiation charts at the oncology departments from which the individual patient data were collected. Only patients who did not have a histological diagnosis date and death date/last follow-up date were excluded (n = 141). Among the 1146 patients with non-small cell carcinoma eligible for analysis, 919 were diagnosed with either adenocarcinoma (n = 323) or squamous cell carcinoma (n = 596) and included in this study. The median survival for the 919 patients was 14.8 months, while the 5-year survival rate was 9.5%. Patients with adenocarcinoma had a significantly better overall survival compared with patients with squamous cell carcinoma (p = 0.0062, log-rank test). When comparing different stages, this survival benefit was most pronounced for stages IIA-IIB (p&lt;0.0001, log-rank test). The difference in survival between the two histological groups was statistically significant in a univariate Cox analysis (p = 0.0063) as well as in two multivariate Cox analyses including demographic and treatment variables (p = 0.037 and p = 0.048, respectively). In this large population based retrospective study we describe for the first time that patients with adenocarcinoma have a better survival after curatively intended radiation therapy in comparison with squamous cell carcinoma patients, particularly those with clinical stages IIA-IIB. (C) 2011 Elsevier Ltd. All rights reserved.},
  author       = {Holgersson, Georg and Bergstrom, Stefan and Bergqvist, Michael and Nyman, Jan and Hoye, Even and Helsing, Martin and Friesland, Signe and Holgersson, Margareta and Birath, Elisabet and Ekrnan, Simon and Blystad, Thomas and Ewers, Sven-Börje and Morth, Charlotte and Loden, Britta and Henriksson, Roger},
  issn         = {1879-0852},
  keyword      = {Lung cancer,Non-small cell lung cancer,Histology,Predictive value,Adenocarcinoma,Squamous cell carcinoma},
  language     = {eng},
  number       = {16},
  pages        = {2415--2421},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Swedish Lung Cancer Radiation Study Group: Predictive value of histology for radiotherapy response in patients with non-small cell lung cancer},
  url          = {http://dx.doi.org/10.1016/j.ejca.2011.06.011},
  volume       = {47},
  year         = {2011},
}