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Calcitonin gene-related peptide in cervicogenic headache

Frese, A; Schilgen, M; Edvinsson, Lars LU ; Frandsen, E and Evers, S (2005) In Cephalalgia 25(9). p.700-703
Abstract
Trigeminovascular activation is involved in the pathophysiology of migraine and cluster headache. The marker evaluated best for trigeminovascular activation is calcitonin gene-related peptide (CGRP) in the cranial circulation. It is unknown whether trigeminovascular activation plays any role in cervicogenic headache (CEH). The objective of this study was to investigate CGRP plasma levels in CEH patients in relation to headache state. To compare plasma CGRP levels between the peripheral and the cranial circulation. Blood from both external jugular veins and from the antecubital vein was drawn from 11 patients with CEH. Plasma CGRP levels were measured by radioimmunoassay. No difference was found between CGRP levels assessed on days with and... (More)
Trigeminovascular activation is involved in the pathophysiology of migraine and cluster headache. The marker evaluated best for trigeminovascular activation is calcitonin gene-related peptide (CGRP) in the cranial circulation. It is unknown whether trigeminovascular activation plays any role in cervicogenic headache (CEH). The objective of this study was to investigate CGRP plasma levels in CEH patients in relation to headache state. To compare plasma CGRP levels between the peripheral and the cranial circulation. Blood from both external jugular veins and from the antecubital vein was drawn from 11 patients with CEH. Plasma CGRP levels were measured by radioimmunoassay. No difference was found between CGRP levels assessed on days with and without headache. There was no difference beween CGRP levels from the symptomatic and the asymptomatic external jugular vein and the antecubital vein. There is no evidence for an activation of the trigeminovascular system in CEH. In certain cases, clinical differentiation between CEH and migraine without aura is difficult. Plasma CGRP levels might serve as a biological marker to distinguish the two headache entities. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
trigeminovascular activation, Cervicogenic headache, migraine, calcitonin gene-related peptide
in
Cephalalgia
volume
25
issue
9
pages
700 - 703
publisher
Wiley-Blackwell
external identifiers
  • wos:000231262300003
  • pmid:16109051
  • scopus:23944503514
ISSN
0333-1024
DOI
10.1111/j.1468-2982.2004.00940.x
language
English
LU publication?
yes
id
f47df7d6-9945-4e7d-845b-f51e882f7af6 (old id 229363)
date added to LUP
2007-08-07 13:01:40
date last changed
2017-06-11 04:26:42
@article{f47df7d6-9945-4e7d-845b-f51e882f7af6,
  abstract     = {Trigeminovascular activation is involved in the pathophysiology of migraine and cluster headache. The marker evaluated best for trigeminovascular activation is calcitonin gene-related peptide (CGRP) in the cranial circulation. It is unknown whether trigeminovascular activation plays any role in cervicogenic headache (CEH). The objective of this study was to investigate CGRP plasma levels in CEH patients in relation to headache state. To compare plasma CGRP levels between the peripheral and the cranial circulation. Blood from both external jugular veins and from the antecubital vein was drawn from 11 patients with CEH. Plasma CGRP levels were measured by radioimmunoassay. No difference was found between CGRP levels assessed on days with and without headache. There was no difference beween CGRP levels from the symptomatic and the asymptomatic external jugular vein and the antecubital vein. There is no evidence for an activation of the trigeminovascular system in CEH. In certain cases, clinical differentiation between CEH and migraine without aura is difficult. Plasma CGRP levels might serve as a biological marker to distinguish the two headache entities.},
  author       = {Frese, A and Schilgen, M and Edvinsson, Lars and Frandsen, E and Evers, S},
  issn         = {0333-1024},
  keyword      = {trigeminovascular activation,Cervicogenic headache,migraine,calcitonin gene-related peptide},
  language     = {eng},
  number       = {9},
  pages        = {700--703},
  publisher    = {Wiley-Blackwell},
  series       = {Cephalalgia},
  title        = {Calcitonin gene-related peptide in cervicogenic headache},
  url          = {http://dx.doi.org/10.1111/j.1468-2982.2004.00940.x},
  volume       = {25},
  year         = {2005},
}