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A simplified laminin nomenclature

Aumailley, M; Bruckner-Tuderman, L; Carter, W G; Deutzmann, R; Edgar, D; Ekblom, Peter LU ; Engel, J; Engvall, E; Hohenester, E and Jones, J C R, et al. (2005) In Matrix Biology 24(5). p.326-332
Abstract
A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha 5 beta 1 gamma 1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin... (More)
A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha 5 beta 1 gamma 1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin epidermal growth factor-like (LE) domains are renumbered starting at the N-termini, to be consistent with general protein nomenclature. Domain IVb of alpha chains is named laminin 4a (L4a), domain IVa of alpha chains is named L4b, domain IV of gamma chains is named L4, and domain IV of beta chains is named laminin four (LF). The two coiled-coil domains I and II are now considered one laminin coiled-coil domain (LCC). The interruption in the coiled-coil of 13 chains is named laminin beta-knob (L beta) domain. The chain origin of a domain is specified by the chain nomenclature, such as alpha IL4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
laminin-type domains, basement membrane, laminin, nomenclature
in
Matrix Biology
volume
24
issue
5
pages
326 - 332
publisher
Elsevier
external identifiers
  • pmid:15979864
  • wos:000231205300002
  • scopus:22544480570
ISSN
1569-1802
DOI
10.1016/j.matbio.2005.05.006
language
English
LU publication?
yes
id
8dc9b6d9-39e2-414c-8bee-94c2e8247da0 (old id 229551)
date added to LUP
2007-08-02 11:36:25
date last changed
2017-11-19 04:14:28
@article{8dc9b6d9-39e2-414c-8bee-94c2e8247da0,
  abstract     = {A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha 5 beta 1 gamma 1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin epidermal growth factor-like (LE) domains are renumbered starting at the N-termini, to be consistent with general protein nomenclature. Domain IVb of alpha chains is named laminin 4a (L4a), domain IVa of alpha chains is named L4b, domain IV of gamma chains is named L4, and domain IV of beta chains is named laminin four (LF). The two coiled-coil domains I and II are now considered one laminin coiled-coil domain (LCC). The interruption in the coiled-coil of 13 chains is named laminin beta-knob (L beta) domain. The chain origin of a domain is specified by the chain nomenclature, such as alpha IL4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered.},
  author       = {Aumailley, M and Bruckner-Tuderman, L and Carter, W G and Deutzmann, R and Edgar, D and Ekblom, Peter and Engel, J and Engvall, E and Hohenester, E and Jones, J C R and Kleinman, H K and Marinkovich, M P and Martin, G R and Mayer, U and Meneguzzi, G and Miner, J H and Miyazaki, K and Patarroyo, M and Paulsson, M and Quaranta, V and Sanes, J R and Sasaki, T and Sekiguchi, K and Sorokin, Lydia and Talts, Jan and Tryggvason, K and Uitto, J and Virtanen, I and von der Mark, K and Wewer, U M and Yamada, Y and Yurchenco, P D},
  issn         = {1569-1802},
  keyword      = {laminin-type domains,basement membrane,laminin,nomenclature},
  language     = {eng},
  number       = {5},
  pages        = {326--332},
  publisher    = {Elsevier},
  series       = {Matrix Biology},
  title        = {A simplified laminin nomenclature},
  url          = {http://dx.doi.org/10.1016/j.matbio.2005.05.006},
  volume       = {24},
  year         = {2005},
}