From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications
(2011) In Blood 118(24). p.6258-6268- Abstract
- This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis.... (More)
- This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis. (Blood. 2011;118(24):6258-6268) (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2295925
- author
- Hattangadi, Shilpa M. ; Wong, Piu ; Zhang, Lingbo ; Flygare, Johan LU and Lodish, Harvey F.
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 118
- issue
- 24
- pages
- 6258 - 6268
- publisher
- American Society of Hematology
- external identifiers
-
- wos:000298040100008
- scopus:83455220200
- pmid:21998215
- ISSN
- 1528-0020
- DOI
- 10.1182/blood-2011-07-356006
- language
- English
- LU publication?
- yes
- id
- 9b8bd5fe-5074-4f23-a76f-23cc3fb1655e (old id 2295925)
- date added to LUP
- 2016-04-01 10:18:43
- date last changed
- 2022-04-20 00:47:48
@article{9b8bd5fe-5074-4f23-a76f-23cc3fb1655e,
abstract = {{This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis. (Blood. 2011;118(24):6258-6268)}},
author = {{Hattangadi, Shilpa M. and Wong, Piu and Zhang, Lingbo and Flygare, Johan and Lodish, Harvey F.}},
issn = {{1528-0020}},
language = {{eng}},
number = {{24}},
pages = {{6258--6268}},
publisher = {{American Society of Hematology}},
series = {{Blood}},
title = {{From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications}},
url = {{http://dx.doi.org/10.1182/blood-2011-07-356006}},
doi = {{10.1182/blood-2011-07-356006}},
volume = {{118}},
year = {{2011}},
}