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From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

Hattangadi, Shilpa M.; Wong, Piu; Zhang, Lingbo; Flygare, Johan LU and Lodish, Harvey F. (2011) In Blood 118(24). p.6258-6268
Abstract
This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis.... (More)
This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis. (Blood. 2011;118(24):6258-6268) (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
118
issue
24
pages
6258 - 6268
publisher
American Society of Hematology
external identifiers
  • wos:000298040100008
  • scopus:83455220200
ISSN
1528-0020
DOI
10.1182/blood-2011-07-356006
language
English
LU publication?
yes
id
9b8bd5fe-5074-4f23-a76f-23cc3fb1655e (old id 2295925)
date added to LUP
2012-01-18 11:21:30
date last changed
2017-11-19 03:08:59
@article{9b8bd5fe-5074-4f23-a76f-23cc3fb1655e,
  abstract     = {This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis. (Blood. 2011;118(24):6258-6268)},
  author       = {Hattangadi, Shilpa M. and Wong, Piu and Zhang, Lingbo and Flygare, Johan and Lodish, Harvey F.},
  issn         = {1528-0020},
  language     = {eng},
  number       = {24},
  pages        = {6258--6268},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications},
  url          = {http://dx.doi.org/10.1182/blood-2011-07-356006},
  volume       = {118},
  year         = {2011},
}