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Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study

Lindqvist, Ebba K.; Goldin, Lynn R.; Landgren, Ola; Blimark, Cecilie; Mellqvist, Ulf-Henrik; Turesson, Ingemar LU ; Wahlin, Anders; Bjorkholm, Magnus and Kristinsson, Sigurdur Y. (2011) In Blood 118(24). p.6284-6291
Abstract
The associations between immune-related conditions and multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) have previously been investigated with inconsistent results. In a large population-based study, we identified 19 112 patients with MM, 5403 patients with MGUS, 96 617 matched control subjects, and 262 931 first-degree relatives. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for the association of MM and MGUS with immune-related conditions by use of logistic regression. A personal history of all infections combined was associated with a significantly increased risk of MM (OR = 1.2; 95% CI, 1.1-1.3), and a personal history of all conditions in the categories infections (OR = 1.6; 95%... (More)
The associations between immune-related conditions and multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) have previously been investigated with inconsistent results. In a large population-based study, we identified 19 112 patients with MM, 5403 patients with MGUS, 96 617 matched control subjects, and 262 931 first-degree relatives. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for the association of MM and MGUS with immune-related conditions by use of logistic regression. A personal history of all infections combined was associated with a significantly increased risk of MM (OR = 1.2; 95% CI, 1.1-1.3), and a personal history of all conditions in the categories infections (OR = 1.6; 95% CI, 1.5-1.7), inflammatory conditions (OR = 1.4; 95% CI, 1.2-1.5), and autoimmune diseases (OR = 2.1; 95% CI, 1.9-2.4) was associated with a significantly increased risk of MGUS. Several specific immune-related conditions elevated the risk of MM and/or MGUS. A family history of autoimmune disease was associated with a significantly increased risk of MGUS (OR = 1.1; 95% CI, 1.00-1.2), but not MM. Our findings suggest that immune-related conditions and/or their treatment are of importance in the etiology of MGUS and possibly MM. The association of both personal and family history of autoimmune disease with MGUS indicates the potential for shared susceptibility for these conditions. (Blood. 2011; 118(24): 6284-6291) (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
118
issue
24
pages
6284 - 6291
publisher
American Society of Hematology
external identifiers
  • wos:000298040100011
  • scopus:83455259553
ISSN
1528-0020
DOI
10.1182/blood-2011-04-347559
language
English
LU publication?
yes
id
dfe7211f-dcc2-4738-8c7e-d3bdf87161f5 (old id 2295932)
date added to LUP
2012-01-18 11:22:40
date last changed
2017-07-09 03:06:27
@article{dfe7211f-dcc2-4738-8c7e-d3bdf87161f5,
  abstract     = {The associations between immune-related conditions and multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) have previously been investigated with inconsistent results. In a large population-based study, we identified 19 112 patients with MM, 5403 patients with MGUS, 96 617 matched control subjects, and 262 931 first-degree relatives. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for the association of MM and MGUS with immune-related conditions by use of logistic regression. A personal history of all infections combined was associated with a significantly increased risk of MM (OR = 1.2; 95% CI, 1.1-1.3), and a personal history of all conditions in the categories infections (OR = 1.6; 95% CI, 1.5-1.7), inflammatory conditions (OR = 1.4; 95% CI, 1.2-1.5), and autoimmune diseases (OR = 2.1; 95% CI, 1.9-2.4) was associated with a significantly increased risk of MGUS. Several specific immune-related conditions elevated the risk of MM and/or MGUS. A family history of autoimmune disease was associated with a significantly increased risk of MGUS (OR = 1.1; 95% CI, 1.00-1.2), but not MM. Our findings suggest that immune-related conditions and/or their treatment are of importance in the etiology of MGUS and possibly MM. The association of both personal and family history of autoimmune disease with MGUS indicates the potential for shared susceptibility for these conditions. (Blood. 2011; 118(24): 6284-6291)},
  author       = {Lindqvist, Ebba K. and Goldin, Lynn R. and Landgren, Ola and Blimark, Cecilie and Mellqvist, Ulf-Henrik and Turesson, Ingemar and Wahlin, Anders and Bjorkholm, Magnus and Kristinsson, Sigurdur Y.},
  issn         = {1528-0020},
  language     = {eng},
  number       = {24},
  pages        = {6284--6291},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study},
  url          = {http://dx.doi.org/10.1182/blood-2011-04-347559},
  volume       = {118},
  year         = {2011},
}