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Epigenetic differences arise during the lifetime of monozygotic twins

Fraga, MF; Ballestar, E; Paz, MF; Ropero, S; Setien, F; Ballestart, ML; Heine-Suner, D; Cigudosa, JC; Urioste, M and Benitez, J, et al. (2005) In Proceedings of the National Academy of Sciences 102(30). p.10604-10609
Abstract
Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of... (More)
Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype. (Less)
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publication status
published
subject
keywords
DNA methylation, epigenetics, histones
in
Proceedings of the National Academy of Sciences
volume
102
issue
30
pages
10604 - 10609
publisher
National Acad Sciences
external identifiers
  • wos:000230853300037
  • scopus:23044514669
ISSN
1091-6490
DOI
10.1073/pnas.0500398102
language
English
LU publication?
yes
id
6d048954-aa10-4d6a-bfbc-35d8ea3e5eee (old id 229877)
date added to LUP
2007-08-10 12:05:31
date last changed
2017-10-29 03:31:18
@article{6d048954-aa10-4d6a-bfbc-35d8ea3e5eee,
  abstract     = {Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype.},
  author       = {Fraga, MF and Ballestar, E and Paz, MF and Ropero, S and Setien, F and Ballestart, ML and Heine-Suner, D and Cigudosa, JC and Urioste, M and Benitez, J and Boix-Chornet, M and Sanchez-Aguilera, A and Ling, Charlotte and Nilsson, Emma A and Poulsen, P and Vaag, A and Stephan, Z and Spector, TD and Wu, YZ and Plass, C and Esteller, M},
  issn         = {1091-6490},
  keyword      = {DNA methylation,epigenetics,histones},
  language     = {eng},
  number       = {30},
  pages        = {10604--10609},
  publisher    = {National Acad Sciences},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {Epigenetic differences arise during the lifetime of monozygotic twins},
  url          = {http://dx.doi.org/10.1073/pnas.0500398102},
  volume       = {102},
  year         = {2005},
}