Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Pleiotropic anticoagulant functions of protein S, consequences for the clinical laboratory. Communication from the SSC of the ISTH

Brinkman, Herm Jan M. ; Ahnström, Josefin LU ; Castoldi, Elisabetta ; Dahlbäck, Björn LU and Marlar, Richard A. (2021) In Journal of Thrombosis and Haemostasis 19(1). p.281-286
Abstract

Hereditary deficiencies of protein S (PS) increase the risk of thrombosis. However, assessing the plasma levels of PS is complicated by its manifold physiological interactions, while the large inter-individual variability makes it problematic to establish reliable cut-off values. PS has multiple physiological functions, with only two appearing to have significant anticoagulant properties: the activated protein C (APC) and tissue factor pathway inhibitor alpha (TFPIα) cofactor activities. Current clinical laboratory investigations for deficiency in PS function rely only on the APC-dependent activity. This communication presents an argument for reclassifying the qualitative PS deficiencies to differentiate the two major anticoagulant... (More)

Hereditary deficiencies of protein S (PS) increase the risk of thrombosis. However, assessing the plasma levels of PS is complicated by its manifold physiological interactions, while the large inter-individual variability makes it problematic to establish reliable cut-off values. PS has multiple physiological functions, with only two appearing to have significant anticoagulant properties: the activated protein C (APC) and tissue factor pathway inhibitor alpha (TFPIα) cofactor activities. Current clinical laboratory investigations for deficiency in PS function rely only on the APC-dependent activity. This communication presents an argument for reclassifying the qualitative PS deficiencies to differentiate the two major anticoagulant functions of PS. Reliable assays are necessary for accurate evaluation of PS function when making a specific diagnosis of PS deficiency based on the anticoagulant phenotype alone. This report emphasizes the pleiotropic anticoagulant functions of PS and presents evidence-based recommendations for their implementation in the clinical laboratory.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
protein S, protein S deficiency
in
Journal of Thrombosis and Haemostasis
volume
19
issue
1
pages
6 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85098780534
  • pmid:33405384
ISSN
1538-7933
DOI
10.1111/jth.15108
language
English
LU publication?
yes
id
22aac6b2-5ba7-4ee9-9063-503c442f9cfc
date added to LUP
2021-01-13 12:53:04
date last changed
2024-04-18 00:01:30
@article{22aac6b2-5ba7-4ee9-9063-503c442f9cfc,
  abstract     = {{<p>Hereditary deficiencies of protein S (PS) increase the risk of thrombosis. However, assessing the plasma levels of PS is complicated by its manifold physiological interactions, while the large inter-individual variability makes it problematic to establish reliable cut-off values. PS has multiple physiological functions, with only two appearing to have significant anticoagulant properties: the activated protein C (APC) and tissue factor pathway inhibitor alpha (TFPIα) cofactor activities. Current clinical laboratory investigations for deficiency in PS function rely only on the APC-dependent activity. This communication presents an argument for reclassifying the qualitative PS deficiencies to differentiate the two major anticoagulant functions of PS. Reliable assays are necessary for accurate evaluation of PS function when making a specific diagnosis of PS deficiency based on the anticoagulant phenotype alone. This report emphasizes the pleiotropic anticoagulant functions of PS and presents evidence-based recommendations for their implementation in the clinical laboratory.</p>}},
  author       = {{Brinkman, Herm Jan M. and Ahnström, Josefin and Castoldi, Elisabetta and Dahlbäck, Björn and Marlar, Richard A.}},
  issn         = {{1538-7933}},
  keywords     = {{protein S; protein S deficiency}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{281--286}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Thrombosis and Haemostasis}},
  title        = {{Pleiotropic anticoagulant functions of protein S, consequences for the clinical laboratory. Communication from the SSC of the ISTH}},
  url          = {{http://dx.doi.org/10.1111/jth.15108}},
  doi          = {{10.1111/jth.15108}},
  volume       = {{19}},
  year         = {{2021}},
}