Early life determinants of lung function change from childhood to adolescence
(2018) In Respiratory Medicine 139. p.48-54- Abstract
RATIONALE: Little is known about how perinatal and childhood factors influence lung function change between childhood and adolescence.
OBJECTIVES: To investigate possible early life predictors of change in FEV1 between age 8 and 16 years. In addition, to investigate possible predictors of having persistently low lung function (FEV1 <25th percentiles both at age 8 and 16) up to adolescence.
METHODS: The BAMSE birth cohort study collected data throughout childhood on environmental factors, individual characteristics, and spirometric measures at 8 and 16 years (n = 1425). Associations between early life predictors (n = 31) and FEV1 increase between 8 and 16 years were assessed with linear regression. Predictors of having... (More)
RATIONALE: Little is known about how perinatal and childhood factors influence lung function change between childhood and adolescence.
OBJECTIVES: To investigate possible early life predictors of change in FEV1 between age 8 and 16 years. In addition, to investigate possible predictors of having persistently low lung function (FEV1 <25th percentiles both at age 8 and 16) up to adolescence.
METHODS: The BAMSE birth cohort study collected data throughout childhood on environmental factors, individual characteristics, and spirometric measures at 8 and 16 years (n = 1425). Associations between early life predictors (n = 31) and FEV1 increase between 8 and 16 years were assessed with linear regression. Predictors of having persistently low lung function were examined.
RESULTS: Few factors were consistently associated with altered lung function growth, although low birth weight, asthma heredity (paternal), secondhand smoke in infancy, and season of birth had a significant impact (p-value ≤0.01). The majority of subjects stayed however within the same category of lung function between ages 8 and 16 years (in total 821/1425 = 58%). Predictors associated with having persistently low lung function were gestational age, secondhand smoke (at 2 and 8 years of age), and factors related to lower respiratory tract infections in infancy.
CONCLUSIONS: In summary, rather few exposures in childhood were identified to have a significant impact on lung function growth between childhood and adolescence. Our data support previous study findings indicating that lung function development is influenced by factors before birth and in infancy, including second hand tobacco smoke.
(Less)
- author
- publishing date
- 2018-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Child, Cohort Studies, Female, Gestational Age, Humans, Infant, Low Birth Weight, Lung/growth & development, Lung Diseases/diagnosis, Male, Respiratory Function Tests, Respiratory Tract Infections/complications, Risk Factors, Spirometry, Tobacco Smoke Pollution/adverse effects
- in
- Respiratory Medicine
- volume
- 139
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:29858001
- scopus:85046730969
- ISSN
- 1532-3064
- DOI
- 10.1016/j.rmed.2018.04.009
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2018. Published by Elsevier Ltd.
- id
- 22fb5fc3-2578-4aef-a98c-99112a3ce89c
- date added to LUP
- 2023-05-08 10:56:22
- date last changed
- 2024-05-03 22:46:26
@article{22fb5fc3-2578-4aef-a98c-99112a3ce89c,
abstract = {{<p>RATIONALE: Little is known about how perinatal and childhood factors influence lung function change between childhood and adolescence.</p><p>OBJECTIVES: To investigate possible early life predictors of change in FEV1 between age 8 and 16 years. In addition, to investigate possible predictors of having persistently low lung function (FEV1 <25th percentiles both at age 8 and 16) up to adolescence.</p><p>METHODS: The BAMSE birth cohort study collected data throughout childhood on environmental factors, individual characteristics, and spirometric measures at 8 and 16 years (n = 1425). Associations between early life predictors (n = 31) and FEV1 increase between 8 and 16 years were assessed with linear regression. Predictors of having persistently low lung function were examined.</p><p>RESULTS: Few factors were consistently associated with altered lung function growth, although low birth weight, asthma heredity (paternal), secondhand smoke in infancy, and season of birth had a significant impact (p-value ≤0.01). The majority of subjects stayed however within the same category of lung function between ages 8 and 16 years (in total 821/1425 = 58%). Predictors associated with having persistently low lung function were gestational age, secondhand smoke (at 2 and 8 years of age), and factors related to lower respiratory tract infections in infancy.</p><p>CONCLUSIONS: In summary, rather few exposures in childhood were identified to have a significant impact on lung function growth between childhood and adolescence. Our data support previous study findings indicating that lung function development is influenced by factors before birth and in infancy, including second hand tobacco smoke.</p>}},
author = {{Schultz, Erica S and Hallberg, Jenny and Andersson, Niklas and Thacher, Jesse D and Pershagen, Göran and Bellander, Tom and Bergström, Anna and Kull, Inger and Guerra, Stefano and Thunqvist, Per and Gustafsson, Per M and Bottai, Matteo and Melén, Erik}},
issn = {{1532-3064}},
keywords = {{Adolescent; Child; Cohort Studies; Female; Gestational Age; Humans; Infant, Low Birth Weight; Lung/growth & development; Lung Diseases/diagnosis; Male; Respiratory Function Tests; Respiratory Tract Infections/complications; Risk Factors; Spirometry; Tobacco Smoke Pollution/adverse effects}},
language = {{eng}},
pages = {{48--54}},
publisher = {{Elsevier}},
series = {{Respiratory Medicine}},
title = {{Early life determinants of lung function change from childhood to adolescence}},
url = {{http://dx.doi.org/10.1016/j.rmed.2018.04.009}},
doi = {{10.1016/j.rmed.2018.04.009}},
volume = {{139}},
year = {{2018}},
}