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Antimicrobials in urogenital infections

Wagenlehner, Florian M. E.; Wullt, Björn LU and Perletti, Gianpaolo (2011) In International Journal of Antimicrobial Agents 38(Suppl.). p.3-10
Abstract
Urinary tract infections (UTIs) and male genital infections are amongst the most prevalent infections. A prudent antibiotic policy therefore has a large impact on society. The clinical classification in uncomplicated cystitis, uncomplicated pyelonephritis, complicated UTI and genital infections is useful, also for the right choice of antibiotic treatment. In this regard pharmacokinetic and pharmacodynamic aspects have to be considered. Nowadays in uncomplicated cystitis antibiotics exclusively reserved for this indication are preferred, such as fosfomycin trometamol, nitrofurantoin and pivmecillinam, in order to reduce antibiotic pressure in this extremely frequent entity. In complicated UTI a broad bacterial spectrum has to be considered.... (More)
Urinary tract infections (UTIs) and male genital infections are amongst the most prevalent infections. A prudent antibiotic policy therefore has a large impact on society. The clinical classification in uncomplicated cystitis, uncomplicated pyelonephritis, complicated UTI and genital infections is useful, also for the right choice of antibiotic treatment. In this regard pharmacokinetic and pharmacodynamic aspects have to be considered. Nowadays in uncomplicated cystitis antibiotics exclusively reserved for this indication are preferred, such as fosfomycin trometamol, nitrofurantoin and pivmecillinam, in order to reduce antibiotic pressure in this extremely frequent entity. In complicated UTI a broad bacterial spectrum has to be considered. Different antibiotic substances should be used for treatment, such as penicillins, with beta-lactamase inhibitors, cephalosporins or carbapenems, fluoroquinolones, aminoglycosides or cotrimoxazole, if tested susceptible. For genital infections the pharmacokinetic properties of the antibiotics should especially be considered, such as in prostatitis, where mainly fluoroquinolones and macrolides show sufficient pharmacokinetic parameters for treatment of bacterial infections. Furthermore in genital infections fastidious organisms, such as Chlamydia or Mycoplasma spp. have to be considered with respect to their antimicrobial susceptibility. (C) 2011 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Urinary tract infection, Male genital infection, Antibiotic treatment, Antimicrobial substances
in
International Journal of Antimicrobial Agents
volume
38
issue
Suppl.
pages
3 - 10
publisher
Elsevier
external identifiers
  • wos:000298141200002
  • scopus:82655187428
ISSN
1872-7913
DOI
10.1016/j.ijantimicag.2011.09.004
language
English
LU publication?
yes
id
fed006db-5012-474a-85cd-406815f24edf (old id 2333135)
date added to LUP
2012-02-01 07:36:51
date last changed
2017-07-02 03:22:11
@article{fed006db-5012-474a-85cd-406815f24edf,
  abstract     = {Urinary tract infections (UTIs) and male genital infections are amongst the most prevalent infections. A prudent antibiotic policy therefore has a large impact on society. The clinical classification in uncomplicated cystitis, uncomplicated pyelonephritis, complicated UTI and genital infections is useful, also for the right choice of antibiotic treatment. In this regard pharmacokinetic and pharmacodynamic aspects have to be considered. Nowadays in uncomplicated cystitis antibiotics exclusively reserved for this indication are preferred, such as fosfomycin trometamol, nitrofurantoin and pivmecillinam, in order to reduce antibiotic pressure in this extremely frequent entity. In complicated UTI a broad bacterial spectrum has to be considered. Different antibiotic substances should be used for treatment, such as penicillins, with beta-lactamase inhibitors, cephalosporins or carbapenems, fluoroquinolones, aminoglycosides or cotrimoxazole, if tested susceptible. For genital infections the pharmacokinetic properties of the antibiotics should especially be considered, such as in prostatitis, where mainly fluoroquinolones and macrolides show sufficient pharmacokinetic parameters for treatment of bacterial infections. Furthermore in genital infections fastidious organisms, such as Chlamydia or Mycoplasma spp. have to be considered with respect to their antimicrobial susceptibility. (C) 2011 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.},
  author       = {Wagenlehner, Florian M. E. and Wullt, Björn and Perletti, Gianpaolo},
  issn         = {1872-7913},
  keyword      = {Urinary tract infection,Male genital infection,Antibiotic treatment,Antimicrobial substances},
  language     = {eng},
  number       = {Suppl.},
  pages        = {3--10},
  publisher    = {Elsevier},
  series       = {International Journal of Antimicrobial Agents},
  title        = {Antimicrobials in urogenital infections},
  url          = {http://dx.doi.org/10.1016/j.ijantimicag.2011.09.004},
  volume       = {38},
  year         = {2011},
}