Metabolic control by AMPK in white adipose tissue
(2023) In Trends in Endocrinology and Metabolism 34(11). p.704-717- Abstract
White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimulated glucose uptake, but AMPK-induced inhibition of β-adrenergic agonist-stimulated lipolysis might need to be re-evaluated in vivo. The lack of dramatic effects of AMPK activation on basal metabolism in WAT could be advantageous when... (More)
White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimulated glucose uptake, but AMPK-induced inhibition of β-adrenergic agonist-stimulated lipolysis might need to be re-evaluated in vivo. The lack of dramatic effects of AMPK activation on basal metabolism in WAT could be advantageous when treating type 2 diabetes with pharmacological pan-AMPK activators.
(Less)
- author
- Göransson, Olga LU ; Kopietz, Franziska LU and Rider, Mark H.
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adipocyte, AMPK, Drug targeting, glucose uptake, lipogenesis, lipolysis
- in
- Trends in Endocrinology and Metabolism
- volume
- 34
- issue
- 11
- pages
- 14 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:37673765
- scopus:85169921297
- ISSN
- 1043-2760
- DOI
- 10.1016/j.tem.2023.08.011
- language
- English
- LU publication?
- yes
- id
- 23353f6f-0f1b-4825-b788-efdf1401a035
- date added to LUP
- 2023-11-06 14:16:26
- date last changed
- 2024-04-19 04:40:16
@article{23353f6f-0f1b-4825-b788-efdf1401a035, abstract = {{<p>White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimulated glucose uptake, but AMPK-induced inhibition of β-adrenergic agonist-stimulated lipolysis might need to be re-evaluated in vivo. The lack of dramatic effects of AMPK activation on basal metabolism in WAT could be advantageous when treating type 2 diabetes with pharmacological pan-AMPK activators.</p>}}, author = {{Göransson, Olga and Kopietz, Franziska and Rider, Mark H.}}, issn = {{1043-2760}}, keywords = {{adipocyte; AMPK; Drug targeting; glucose uptake; lipogenesis; lipolysis}}, language = {{eng}}, number = {{11}}, pages = {{704--717}}, publisher = {{Elsevier}}, series = {{Trends in Endocrinology and Metabolism}}, title = {{Metabolic control by AMPK in white adipose tissue}}, url = {{http://dx.doi.org/10.1016/j.tem.2023.08.011}}, doi = {{10.1016/j.tem.2023.08.011}}, volume = {{34}}, year = {{2023}}, }