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Metabolic control by AMPK in white adipose tissue

Göransson, Olga LU orcid ; Kopietz, Franziska LU orcid and Rider, Mark H. (2023) In Trends in Endocrinology and Metabolism 34(11). p.704-717
Abstract

White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimulated glucose uptake, but AMPK-induced inhibition of β-adrenergic agonist-stimulated lipolysis might need to be re-evaluated in vivo. The lack of dramatic effects of AMPK activation on basal metabolism in WAT could be advantageous when... (More)

White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimulated glucose uptake, but AMPK-induced inhibition of β-adrenergic agonist-stimulated lipolysis might need to be re-evaluated in vivo. The lack of dramatic effects of AMPK activation on basal metabolism in WAT could be advantageous when treating type 2 diabetes with pharmacological pan-AMPK activators.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adipocyte, AMPK, Drug targeting, glucose uptake, lipogenesis, lipolysis
in
Trends in Endocrinology and Metabolism
volume
34
issue
11
pages
14 pages
publisher
Elsevier
external identifiers
  • pmid:37673765
  • scopus:85169921297
ISSN
1043-2760
DOI
10.1016/j.tem.2023.08.011
language
English
LU publication?
yes
id
23353f6f-0f1b-4825-b788-efdf1401a035
date added to LUP
2023-11-06 14:16:26
date last changed
2024-04-19 04:40:16
@article{23353f6f-0f1b-4825-b788-efdf1401a035,
  abstract     = {{<p>White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimulated glucose uptake, but AMPK-induced inhibition of β-adrenergic agonist-stimulated lipolysis might need to be re-evaluated in vivo. The lack of dramatic effects of AMPK activation on basal metabolism in WAT could be advantageous when treating type 2 diabetes with pharmacological pan-AMPK activators.</p>}},
  author       = {{Göransson, Olga and Kopietz, Franziska and Rider, Mark H.}},
  issn         = {{1043-2760}},
  keywords     = {{adipocyte; AMPK; Drug targeting; glucose uptake; lipogenesis; lipolysis}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{704--717}},
  publisher    = {{Elsevier}},
  series       = {{Trends in Endocrinology and Metabolism}},
  title        = {{Metabolic control by AMPK in white adipose tissue}},
  url          = {{http://dx.doi.org/10.1016/j.tem.2023.08.011}},
  doi          = {{10.1016/j.tem.2023.08.011}},
  volume       = {{34}},
  year         = {{2023}},
}