Advanced

The prevalence of atrial fibrillation in a geographically well-defined population in Northern Sweden: implications for anticoagulation prophylaxis.

Andersson, Per; Löndahl, Magnus LU ; Abdon, Nils-Johan and Terent, Andreas (2012) In Journal of Internal Medicine 272(2). p.170-176
Abstract
Objectives: The aims of this study were to evaluate the community-based prevalence of atrial fibrillation (AF) in a western society using a geographically well-defined population in the northern part of Sweden as a reference and to estimate the proportion of patients eligible for oral anticoagulation (OAC) prophylactic therapy according to the stroke risk indices CHADS(2) and CHA(2) DS(2) -VASc. Bleeding risk was assessed using the HAS-BLED score. Design: The study population was recruited from AURICULA, a Swedish national quality register for patients receiving anticoagulation treatment. All patients with the diagnosis AF in the catchment area are registered in AURICULA. Results: Of the 65,532 inhabitants in the catchment area, 1616 were... (More)
Objectives: The aims of this study were to evaluate the community-based prevalence of atrial fibrillation (AF) in a western society using a geographically well-defined population in the northern part of Sweden as a reference and to estimate the proportion of patients eligible for oral anticoagulation (OAC) prophylactic therapy according to the stroke risk indices CHADS(2) and CHA(2) DS(2) -VASc. Bleeding risk was assessed using the HAS-BLED score. Design: The study population was recruited from AURICULA, a Swedish national quality register for patients receiving anticoagulation treatment. All patients with the diagnosis AF in the catchment area are registered in AURICULA. Results: Of the 65,532 inhabitants in the catchment area, 1616 were diagnosed with AF (1200 cases were characterized as chronic AF). Thus, the overall prevalence of AF was 2.5%. The prevalence increased with age from 6.3% in patients over 55 years of age to 13.8% in those over 80 years. The prevalence was higher in men than in women in all age groups. Overall, 56.3% and 85.1% of the population were at high risk of stroke (≥2 points) according to CHADS(2) and CHA(2) DS(2) -VASc, respectively. In addition, 26.9% had an increased bleeding risk according to HAS-BLED. Conclusion: Within this large Caucasian population, we identified the highest community-based prevalence of AF to date. The prevalence was strongly associated with increasing age and male gender. Using CHA(2) DS(2) -VASc instead of CHADS(2) widened the indication for OAC prophylactic therapy of AF in this population. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine
volume
272
issue
2
pages
170 - 176
publisher
Wiley-Blackwell
external identifiers
  • wos:000306895300009
  • pmid:22250988
  • scopus:84864307121
ISSN
1365-2796
DOI
10.1111/j.1365-2796.2012.02519.x
language
English
LU publication?
yes
id
29345151-7732-4adf-ada2-6e54db1de008 (old id 2336315)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22250988?dopt=Abstract
date added to LUP
2012-02-01 21:44:35
date last changed
2017-01-01 07:51:17
@article{29345151-7732-4adf-ada2-6e54db1de008,
  abstract     = {Objectives: The aims of this study were to evaluate the community-based prevalence of atrial fibrillation (AF) in a western society using a geographically well-defined population in the northern part of Sweden as a reference and to estimate the proportion of patients eligible for oral anticoagulation (OAC) prophylactic therapy according to the stroke risk indices CHADS(2) and CHA(2) DS(2) -VASc. Bleeding risk was assessed using the HAS-BLED score. Design: The study population was recruited from AURICULA, a Swedish national quality register for patients receiving anticoagulation treatment. All patients with the diagnosis AF in the catchment area are registered in AURICULA. Results: Of the 65,532 inhabitants in the catchment area, 1616 were diagnosed with AF (1200 cases were characterized as chronic AF). Thus, the overall prevalence of AF was 2.5%. The prevalence increased with age from 6.3% in patients over 55 years of age to 13.8% in those over 80 years. The prevalence was higher in men than in women in all age groups. Overall, 56.3% and 85.1% of the population were at high risk of stroke (≥2 points) according to CHADS(2) and CHA(2) DS(2) -VASc, respectively. In addition, 26.9% had an increased bleeding risk according to HAS-BLED. Conclusion: Within this large Caucasian population, we identified the highest community-based prevalence of AF to date. The prevalence was strongly associated with increasing age and male gender. Using CHA(2) DS(2) -VASc instead of CHADS(2) widened the indication for OAC prophylactic therapy of AF in this population.},
  author       = {Andersson, Per and Löndahl, Magnus and Abdon, Nils-Johan and Terent, Andreas},
  issn         = {1365-2796},
  language     = {eng},
  number       = {2},
  pages        = {170--176},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Internal Medicine},
  title        = {The prevalence of atrial fibrillation in a geographically well-defined population in Northern Sweden: implications for anticoagulation prophylaxis.},
  url          = {http://dx.doi.org/10.1111/j.1365-2796.2012.02519.x},
  volume       = {272},
  year         = {2012},
}