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Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men

Pitteloud, N; Mootha, VK; Dwyer, AA; Hardin, M; Lee, H; Eriksson, Karl-Fredrik LU ; Tripathy, Devjit LU ; Yialamas, M; Groop, Leif LU and Elahi, D, et al. (2005) In Diabetes Care 28(7). p.1636-1642
Abstract
OBJECTIVE - The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity and mitochondrial function in men, RESEARCH DESIGN AND METHODS - A total of 60 men (mean age 60.5 +/- 1.2 years) had a detailed hormonal and metabolic evaluation. Insulin sensitivity was measured Using a hyperinsulinemic-euglycemic clamp. Mitochondrial function was assessed by measuring maximal aerobic capacity (Vo(2max)) and expression of oxidative phosphorylation gene,, in skeletal muscle, RESULTS - A total of 45% of subjects had normal glucose tolerance, 20% had impaired glucose tolerance, and 35% had type 2 diabetes. Testosterone levels were correlated with insulin sensitivity (r = 0.4, P < 0.005). Subjects... (More)
OBJECTIVE - The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity and mitochondrial function in men, RESEARCH DESIGN AND METHODS - A total of 60 men (mean age 60.5 +/- 1.2 years) had a detailed hormonal and metabolic evaluation. Insulin sensitivity was measured Using a hyperinsulinemic-euglycemic clamp. Mitochondrial function was assessed by measuring maximal aerobic capacity (Vo(2max)) and expression of oxidative phosphorylation gene,, in skeletal muscle, RESULTS - A total of 45% of subjects had normal glucose tolerance, 20% had impaired glucose tolerance, and 35% had type 2 diabetes. Testosterone levels were correlated with insulin sensitivity (r = 0.4, P < 0.005). Subjects with hypogonadal testosterone levels (n = 10) had a BMI > 25 kg/m(2) and a threefold higher prevalence of the metabolic syndrome than their eugonadal counterparts (n = 50) this relationship held true after adjusting for age and sex hormone-binding globulin but not BMI. Testosterone levels also correlated with (Vo(2max),11 0 = 0.43, P < 0.05) and oxidative phosphorylation gene expression (r = 0.57, P < 0.0001). CONCLUSIONS - These data indicate that low serum testosterone levels are associated with an adverse metabolic profile and suggest a novel unifying mechanism for the previously independent observations that low testosterone levels and impaired mitochondrial function promote insulin resistance in men. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
28
issue
7
pages
1636 - 1642
publisher
American Diabetes Association
external identifiers
  • wos:000230163800015
  • pmid:15983313
  • scopus:24944450769
ISSN
1935-5548
language
English
LU publication?
yes
id
b0040020-7e22-4f79-8c05-ac64bd97af42 (old id 233873)
alternative location
http://care.diabetesjournals.org/cgi/content/full/28/7/1636
date added to LUP
2007-08-23 17:46:51
date last changed
2017-10-22 04:38:11
@article{b0040020-7e22-4f79-8c05-ac64bd97af42,
  abstract     = {OBJECTIVE - The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity and mitochondrial function in men, RESEARCH DESIGN AND METHODS - A total of 60 men (mean age 60.5 +/- 1.2 years) had a detailed hormonal and metabolic evaluation. Insulin sensitivity was measured Using a hyperinsulinemic-euglycemic clamp. Mitochondrial function was assessed by measuring maximal aerobic capacity (Vo(2max)) and expression of oxidative phosphorylation gene,, in skeletal muscle, RESULTS - A total of 45% of subjects had normal glucose tolerance, 20% had impaired glucose tolerance, and 35% had type 2 diabetes. Testosterone levels were correlated with insulin sensitivity (r = 0.4, P &lt; 0.005). Subjects with hypogonadal testosterone levels (n = 10) had a BMI &gt; 25 kg/m(2) and a threefold higher prevalence of the metabolic syndrome than their eugonadal counterparts (n = 50) this relationship held true after adjusting for age and sex hormone-binding globulin but not BMI. Testosterone levels also correlated with (Vo(2max),11 0 = 0.43, P &lt; 0.05) and oxidative phosphorylation gene expression (r = 0.57, P &lt; 0.0001). CONCLUSIONS - These data indicate that low serum testosterone levels are associated with an adverse metabolic profile and suggest a novel unifying mechanism for the previously independent observations that low testosterone levels and impaired mitochondrial function promote insulin resistance in men.},
  author       = {Pitteloud, N and Mootha, VK and Dwyer, AA and Hardin, M and Lee, H and Eriksson, Karl-Fredrik and Tripathy, Devjit and Yialamas, M and Groop, Leif and Elahi, D and Hayes, FJ},
  issn         = {1935-5548},
  language     = {eng},
  number       = {7},
  pages        = {1636--1642},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men},
  volume       = {28},
  year         = {2005},
}