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A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients

Belsito, D.; Bickers, D.; Bruze, Magnus LU ; Calow, P.; Dagli, M.; Fryer, A. D.; Greim, H.; Miyachi, Y.; Saurat, J. H. and Sipes, I. G. (2011) In Food and Chemical Toxicology 49(Suppl. 2). p.256-267
Abstract
The cinnamyl phenylpropyl fragrance ingredients are a diverse group of chemical structures that have similar metabolic and toxicity profiles. A toxicological and dermatological review of these fragrance ingredients is presented. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. For high end users, calculated maximum dermal exposures vary from 0.14% to 0.72%; systemic exposures vary from 0.0002 to 0.0280 mg/kg/day. Human dermatological studies show that these materials are not generally irritants or sensitizers at lower exposures from consumer products. Reactions (0.9%) in fragrance sensitive patients were observed with 3-phenyl-1-propanol at 5% in... (More)
The cinnamyl phenylpropyl fragrance ingredients are a diverse group of chemical structures that have similar metabolic and toxicity profiles. A toxicological and dermatological review of these fragrance ingredients is presented. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. For high end users, calculated maximum dermal exposures vary from 0.14% to 0.72%; systemic exposures vary from 0.0002 to 0.0280 mg/kg/day. Human dermatological studies show that these materials are not generally irritants or sensitizers at lower exposures from consumer products. Reactions (0.9%) in fragrance sensitive patients were observed with 3-phenyl-1-propanol at 5% in petrolatum. The cinnamyl phenylpropyl materials had low acute toxicity and no significant toxicity in repeat dose oral or dermal toxicity studies. No mutagenic or genotoxic activity in bacteria and mammalian cell line assays was observed. The cinnamyl phenylpropyl alcohol materials participate in the same beta oxidation pathways as their parent cinnamic acid derivatives, including common routes of absorption, distribution, and metabolic detoxification, and exhibit similar toxicological endpoints. Based on the review of available data, it is concluded that these materials would not present a safety concern at current levels of use as fragrance ingredients. (C) 2011 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Review, Safety, Fragrance ingredients, Cinnamyl phenylpropyl
in
Food and Chemical Toxicology
volume
49
issue
Suppl. 2
pages
256 - 267
publisher
Elsevier
external identifiers
  • wos:000299404000027
  • scopus:84155160709
ISSN
0278-6915
DOI
10.1016/j.fct.2011.07.053
language
English
LU publication?
yes
id
33f8feb5-52a4-4210-af3e-e2693f3775fe (old id 2344992)
date added to LUP
2012-02-24 13:48:56
date last changed
2017-06-18 04:09:58
@article{33f8feb5-52a4-4210-af3e-e2693f3775fe,
  abstract     = {The cinnamyl phenylpropyl fragrance ingredients are a diverse group of chemical structures that have similar metabolic and toxicity profiles. A toxicological and dermatological review of these fragrance ingredients is presented. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. For high end users, calculated maximum dermal exposures vary from 0.14% to 0.72%; systemic exposures vary from 0.0002 to 0.0280 mg/kg/day. Human dermatological studies show that these materials are not generally irritants or sensitizers at lower exposures from consumer products. Reactions (0.9%) in fragrance sensitive patients were observed with 3-phenyl-1-propanol at 5% in petrolatum. The cinnamyl phenylpropyl materials had low acute toxicity and no significant toxicity in repeat dose oral or dermal toxicity studies. No mutagenic or genotoxic activity in bacteria and mammalian cell line assays was observed. The cinnamyl phenylpropyl alcohol materials participate in the same beta oxidation pathways as their parent cinnamic acid derivatives, including common routes of absorption, distribution, and metabolic detoxification, and exhibit similar toxicological endpoints. Based on the review of available data, it is concluded that these materials would not present a safety concern at current levels of use as fragrance ingredients. (C) 2011 Elsevier Ltd. All rights reserved.},
  author       = {Belsito, D. and Bickers, D. and Bruze, Magnus and Calow, P. and Dagli, M. and Fryer, A. D. and Greim, H. and Miyachi, Y. and Saurat, J. H. and Sipes, I. G.},
  issn         = {0278-6915},
  keyword      = {Review,Safety,Fragrance ingredients,Cinnamyl phenylpropyl},
  language     = {eng},
  number       = {Suppl. 2},
  pages        = {256--267},
  publisher    = {Elsevier},
  series       = {Food and Chemical Toxicology},
  title        = {A toxicologic and dermatologic assessment of cinnamyl phenylpropyl materials when used as fragrance ingredients},
  url          = {http://dx.doi.org/10.1016/j.fct.2011.07.053},
  volume       = {49},
  year         = {2011},
}