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Pregnancy Rate and Outcome in Swedish Women With Turner Syndrome EDITORIAL COMMENT

Bryman, Inger; Sylven, Lisskulla; Berntorp, Kerstin LU ; Innala, Eva; Bergstrom, Ingrid; Hanson, Charles; Oxholm, Marianne and Landin-Wilhelmsen, Kerstin (2011) In Obstetrical and Gynecological Survey 66(12). p.756-757
Abstract
The rate of spontaneous pregnancies in women with Turner syndrome (TS) is low (2% to 5%). Oocyte donation is an option for these women and enables many to become pregnant. Some investigators question the use of pregnancy induction in TS because of the high risk for aortic dissection or other serious cardiac events. A cardiac evaluation is recommended before pregnancy is planned in TS. Among patients with TS who use their own oocytes to become pregnant, 45% suffered a miscarriage. The aim of this study was to assess pregnancy rate and outcome in a population of Swedish women with spontaneous pregnancies or who were induced using donated oocytes. Cytogenetic karyotype also was examined; mosaicism was defined as the presence of more than 5%... (More)
The rate of spontaneous pregnancies in women with Turner syndrome (TS) is low (2% to 5%). Oocyte donation is an option for these women and enables many to become pregnant. Some investigators question the use of pregnancy induction in TS because of the high risk for aortic dissection or other serious cardiac events. A cardiac evaluation is recommended before pregnancy is planned in TS. Among patients with TS who use their own oocytes to become pregnant, 45% suffered a miscarriage. The aim of this study was to assess pregnancy rate and outcome in a population of Swedish women with spontaneous pregnancies or who were induced using donated oocytes. Cytogenetic karyotype also was examined; mosaicism was defined as the presence of more than 5% 46, XX cells. The study subjects were 482 women with TS who had participated in a voluntary screening program conducted at Swedish Turner Centers. Among the 482 women with TS, 57 (12%) had pregnancies, including spontaneous pregnancies. The live-born rate was 67 of 124 (54%). The patient's own oocytes were used in 27 (47%) of the pregnancies and oocyte donation in 30 (53%) of pregnancies. Spontaneous pregnancies occurred in 23 of 57 women (40%) with TS. Most pregnancies using the patient's own oocytes occurred in those with 45, X/46, XX mosaic karyotype. The miscarriage rate was 26% after oocyte donation and 45% with the use of the patient's own oocytes. Five liveborns (7%) had birth defects or a serious illness; 4 of these were born after spontaneous pregnancies. Only 1 live-born had coarctation of the aorta. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obstetrical and Gynecological Survey
volume
66
issue
12
pages
756 - 757
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000298662700011
ISSN
0029-7828
DOI
10.1097/OGX.0b013e318238897d
language
English
LU publication?
yes
id
a54de58f-335d-419a-848f-484da5f1d975 (old id 2348371)
date added to LUP
2012-03-01 11:20:16
date last changed
2016-04-15 15:16:57
@misc{a54de58f-335d-419a-848f-484da5f1d975,
  abstract     = {The rate of spontaneous pregnancies in women with Turner syndrome (TS) is low (2% to 5%). Oocyte donation is an option for these women and enables many to become pregnant. Some investigators question the use of pregnancy induction in TS because of the high risk for aortic dissection or other serious cardiac events. A cardiac evaluation is recommended before pregnancy is planned in TS. Among patients with TS who use their own oocytes to become pregnant, 45% suffered a miscarriage. The aim of this study was to assess pregnancy rate and outcome in a population of Swedish women with spontaneous pregnancies or who were induced using donated oocytes. Cytogenetic karyotype also was examined; mosaicism was defined as the presence of more than 5% 46, XX cells. The study subjects were 482 women with TS who had participated in a voluntary screening program conducted at Swedish Turner Centers. Among the 482 women with TS, 57 (12%) had pregnancies, including spontaneous pregnancies. The live-born rate was 67 of 124 (54%). The patient's own oocytes were used in 27 (47%) of the pregnancies and oocyte donation in 30 (53%) of pregnancies. Spontaneous pregnancies occurred in 23 of 57 women (40%) with TS. Most pregnancies using the patient's own oocytes occurred in those with 45, X/46, XX mosaic karyotype. The miscarriage rate was 26% after oocyte donation and 45% with the use of the patient's own oocytes. Five liveborns (7%) had birth defects or a serious illness; 4 of these were born after spontaneous pregnancies. Only 1 live-born had coarctation of the aorta.},
  author       = {Bryman, Inger and Sylven, Lisskulla and Berntorp, Kerstin and Innala, Eva and Bergstrom, Ingrid and Hanson, Charles and Oxholm, Marianne and Landin-Wilhelmsen, Kerstin},
  issn         = {0029-7828},
  language     = {eng},
  number       = {12},
  pages        = {756--757},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Obstetrical and Gynecological Survey},
  title        = {Pregnancy Rate and Outcome in Swedish Women With Turner Syndrome EDITORIAL COMMENT},
  url          = {http://dx.doi.org/10.1097/OGX.0b013e318238897d},
  volume       = {66},
  year         = {2011},
}