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Extracellular Matrix and Its Receptors in Drosophila Neural Development

Broadie, Kendal; Baumgartner, Stefan LU and Prokop, Andreas (2011) In Developmental Neurobiology 71(11). p.1102-1130
Abstract
Extracellular matrix (ECM) and matrix receptors are intimately involved in most biological processes. The ECM plays fundamental developmental and physiological roles in health and disease, including processes underlying the development, maintenance, and regeneration of the nervous system. To understand the principles of ECM-mediated functions in the nervous system, genetic model organisms like Drosophila provide simple, malleable, and powerful experimental platforms. This article provides an overview of ECM proteins and receptors in Drosophila. It then focuses on their roles during three progressive phases of neural development: (1) neural progenitor proliferation, (2) axonal growth and pathfinding, and (3) synapse formation and function.... (More)
Extracellular matrix (ECM) and matrix receptors are intimately involved in most biological processes. The ECM plays fundamental developmental and physiological roles in health and disease, including processes underlying the development, maintenance, and regeneration of the nervous system. To understand the principles of ECM-mediated functions in the nervous system, genetic model organisms like Drosophila provide simple, malleable, and powerful experimental platforms. This article provides an overview of ECM proteins and receptors in Drosophila. It then focuses on their roles during three progressive phases of neural development: (1) neural progenitor proliferation, (2) axonal growth and pathfinding, and (3) synapse formation and function. Each section highlights known ECM and ECM-receptor components and recent studies done in mutant conditions to reveal their in vivo functions, all illustrating the enormous opportunities provided when merging work on the nervous system with systematic research into ECM-related gene functions. (C) 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 1102-1130, 2011 (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
extracellular matrix, axonal growth, synapse formation, neural stem, cells, Drosophila
in
Developmental Neurobiology
volume
71
issue
11
pages
1102 - 1130
publisher
Wiley-Blackwell
external identifiers
  • wos:000297984800013
  • scopus:80053922028
ISSN
1932-846X
DOI
10.1002/dneu.20935
language
English
LU publication?
yes
id
a5eaff75-1a33-4507-8d99-25a7d940e205 (old id 2348608)
date added to LUP
2012-03-01 11:21:53
date last changed
2017-10-08 03:18:11
@article{a5eaff75-1a33-4507-8d99-25a7d940e205,
  abstract     = {Extracellular matrix (ECM) and matrix receptors are intimately involved in most biological processes. The ECM plays fundamental developmental and physiological roles in health and disease, including processes underlying the development, maintenance, and regeneration of the nervous system. To understand the principles of ECM-mediated functions in the nervous system, genetic model organisms like Drosophila provide simple, malleable, and powerful experimental platforms. This article provides an overview of ECM proteins and receptors in Drosophila. It then focuses on their roles during three progressive phases of neural development: (1) neural progenitor proliferation, (2) axonal growth and pathfinding, and (3) synapse formation and function. Each section highlights known ECM and ECM-receptor components and recent studies done in mutant conditions to reveal their in vivo functions, all illustrating the enormous opportunities provided when merging work on the nervous system with systematic research into ECM-related gene functions. (C) 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 1102-1130, 2011},
  author       = {Broadie, Kendal and Baumgartner, Stefan and Prokop, Andreas},
  issn         = {1932-846X},
  keyword      = {extracellular matrix,axonal growth,synapse formation,neural stem,cells,Drosophila},
  language     = {eng},
  number       = {11},
  pages        = {1102--1130},
  publisher    = {Wiley-Blackwell},
  series       = {Developmental Neurobiology},
  title        = {Extracellular Matrix and Its Receptors in Drosophila Neural Development},
  url          = {http://dx.doi.org/10.1002/dneu.20935},
  volume       = {71},
  year         = {2011},
}