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Cerebrospinal Fluid (CSF) 25-Hydroxyvitamin D Concentration and CSF Acetylcholinesterase Activity Are Reduced in Patients with Alzheimer's Disease

Johansson, Per LU ; Almqvist, Erik G. ; Johansson, Jan-Ove ; Mattsson, Niklas ; Andreasson, Ulf ; Hansson, Oskar LU orcid ; Wallin, Anders ; Blennow, Kaj LU ; Zetterberg, Henrik and Svensson, Johan (2013) In PLoS ONE 8(11).
Abstract
Background: Little is known of vitamin D concentration in cerebrospinal fluid (CSF) in Alzheimer's disease (AD) and its relation with CSF acetylcholinesterase (AChE) activity, a marker of cholinergic function. Methods: A cross-sectional study of 52 consecutive patients under primary evaluation of cognitive impairment and 17 healthy controls. The patients had AD dementia or mild cognitive impairment (MCI) diagnosed with AD dementia upon follow-up (n = 28), other dementias (n = 12), and stable MCI (SMCI, n = 12). We determined serum and CSF concentrations of calcium, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), and CSF activities of AChE and butyrylcholinesterase (BuChE). Findings: CSF 25OHD level was reduced in AD patients (P... (More)
Background: Little is known of vitamin D concentration in cerebrospinal fluid (CSF) in Alzheimer's disease (AD) and its relation with CSF acetylcholinesterase (AChE) activity, a marker of cholinergic function. Methods: A cross-sectional study of 52 consecutive patients under primary evaluation of cognitive impairment and 17 healthy controls. The patients had AD dementia or mild cognitive impairment (MCI) diagnosed with AD dementia upon follow-up (n = 28), other dementias (n = 12), and stable MCI (SMCI, n = 12). We determined serum and CSF concentrations of calcium, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), and CSF activities of AChE and butyrylcholinesterase (BuChE). Findings: CSF 25OHD level was reduced in AD patients (P < 0.05), and CSF AChE activity was decreased both in patients with AD (P < 0.05) and other dementias (P < 0.01) compared to healthy controls. None of the measured variables differed between BuChE K-variant genotypes whereas the participants that were homozygous in terms of the apolipoprotein E (APOE) E4 allele had decreased CSF AChE activity compared to subjects lacking the APOE E4 allele (P = 0.01). In AD patients (n=28), CSF AChE activity correlated positively with CSF levels of total tau (T-tau) (r = 0.44, P < 0.05) and phosphorylated tau protein (P-tau) (r = 0.50, P < 0.01), but CSF activities of AChE or BuChE did not correlate with serum or CSF levels of 25OHD. Conclusions: In this pilot study, both CSF 25OHD level and CSF AChE activity were reduced in AD patients. However, the lack of correlations between 25OHD levels and CSF activities of AChE or BuChE might suggest different mechanisms of action, which could have implications for treatment trials. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
8
issue
11
article number
e81989
publisher
Public Library of Science (PLoS)
external identifiers
  • wos:000327670300062
  • scopus:84896689839
  • pmid:24312390
ISSN
1932-6203
DOI
10.1371/journal.pone.0081989
project
Endocrine and diagnostic aspects of cognitive impairment
language
English
LU publication?
yes
id
2349bd9f-4686-454a-a2c6-1c17af9af960 (old id 4272911)
date added to LUP
2016-04-01 15:05:38
date last changed
2022-05-08 02:23:08
@article{2349bd9f-4686-454a-a2c6-1c17af9af960,
  abstract     = {{Background: Little is known of vitamin D concentration in cerebrospinal fluid (CSF) in Alzheimer's disease (AD) and its relation with CSF acetylcholinesterase (AChE) activity, a marker of cholinergic function. Methods: A cross-sectional study of 52 consecutive patients under primary evaluation of cognitive impairment and 17 healthy controls. The patients had AD dementia or mild cognitive impairment (MCI) diagnosed with AD dementia upon follow-up (n = 28), other dementias (n = 12), and stable MCI (SMCI, n = 12). We determined serum and CSF concentrations of calcium, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), and CSF activities of AChE and butyrylcholinesterase (BuChE). Findings: CSF 25OHD level was reduced in AD patients (P &lt; 0.05), and CSF AChE activity was decreased both in patients with AD (P &lt; 0.05) and other dementias (P &lt; 0.01) compared to healthy controls. None of the measured variables differed between BuChE K-variant genotypes whereas the participants that were homozygous in terms of the apolipoprotein E (APOE) E4 allele had decreased CSF AChE activity compared to subjects lacking the APOE E4 allele (P = 0.01). In AD patients (n=28), CSF AChE activity correlated positively with CSF levels of total tau (T-tau) (r = 0.44, P &lt; 0.05) and phosphorylated tau protein (P-tau) (r = 0.50, P &lt; 0.01), but CSF activities of AChE or BuChE did not correlate with serum or CSF levels of 25OHD. Conclusions: In this pilot study, both CSF 25OHD level and CSF AChE activity were reduced in AD patients. However, the lack of correlations between 25OHD levels and CSF activities of AChE or BuChE might suggest different mechanisms of action, which could have implications for treatment trials.}},
  author       = {{Johansson, Per and Almqvist, Erik G. and Johansson, Jan-Ove and Mattsson, Niklas and Andreasson, Ulf and Hansson, Oskar and Wallin, Anders and Blennow, Kaj and Zetterberg, Henrik and Svensson, Johan}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{11}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Cerebrospinal Fluid (CSF) 25-Hydroxyvitamin D Concentration and CSF Acetylcholinesterase Activity Are Reduced in Patients with Alzheimer's Disease}},
  url          = {{https://lup.lub.lu.se/search/files/4335412/4588729}},
  doi          = {{10.1371/journal.pone.0081989}},
  volume       = {{8}},
  year         = {{2013}},
}