A combined effect of anti-HPA-1a and anti-HLA Class I in pregnancy?
(2020) In Transfusion 60(9). p.2121-2129- Abstract
Background: Maternal anti–human leukocyte antigen (HLA) Class I is commonly detected alongside anti–human platelet antigen (HPA)-1a in fetal and neonatal alloimmune thrombocytopenia (FNAIT). Little is known regarding whether the presence of anti-HLA Class I may exert an additive effect on the risk and severity of FNAIT. Methods and Materials: We reanalyzed samples originally collected as part of a large Norwegian screening study on FNAIT during 1995-2004. This study identified and managed 170 pregnancies where the mother was HPA-1a negative and had detectable anti-HPA-1a during pregnancy. Maternal samples from 166 of these pregnancies were rescreened for anti-HLA Class I, revealing 111 (67%) that were antibody positive. Various... (More)
Background: Maternal anti–human leukocyte antigen (HLA) Class I is commonly detected alongside anti–human platelet antigen (HPA)-1a in fetal and neonatal alloimmune thrombocytopenia (FNAIT). Little is known regarding whether the presence of anti-HLA Class I may exert an additive effect on the risk and severity of FNAIT. Methods and Materials: We reanalyzed samples originally collected as part of a large Norwegian screening study on FNAIT during 1995-2004. This study identified and managed 170 pregnancies where the mother was HPA-1a negative and had detectable anti-HPA-1a during pregnancy. Maternal samples from 166 of these pregnancies were rescreened for anti-HLA Class I, revealing 111 (67%) that were antibody positive. Various regression models were used to assess if and how maternal anti-HLA Class I influenced the neonatal platelet count. Results and Conclusions: Unadjusted neonatal platelet counts and the frequency of neonatal thrombocytopenia was not significantly affected by the presence of anti-HLA Class I alongside anti–HPA-1a, but results from regression analyses revealed a possible increased risk when the mother was nulliparous. These results warrant further investigation.
(Less)
- author
- Dahl, Jesper ; Skogen, Bjørn ; Kjaer, Mette ; Husebekk, Anne ; Kjeldsen-Kragh, Jens LU and Tiller, Heidi
- publishing date
- 2020-06-30
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Transfusion
- volume
- 60
- issue
- 9
- pages
- 2121 - 2129
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:32608103
- scopus:85087153594
- ISSN
- 0041-1132
- DOI
- 10.1111/trf.15944
- language
- English
- LU publication?
- no
- id
- 234fa2dc-34a6-4752-b0d6-94eeb4057ad0
- date added to LUP
- 2020-07-20 11:15:28
- date last changed
- 2024-05-01 14:12:41
@article{234fa2dc-34a6-4752-b0d6-94eeb4057ad0,
abstract = {{<p>Background: Maternal anti–human leukocyte antigen (HLA) Class I is commonly detected alongside anti–human platelet antigen (HPA)-1a in fetal and neonatal alloimmune thrombocytopenia (FNAIT). Little is known regarding whether the presence of anti-HLA Class I may exert an additive effect on the risk and severity of FNAIT. Methods and Materials: We reanalyzed samples originally collected as part of a large Norwegian screening study on FNAIT during 1995-2004. This study identified and managed 170 pregnancies where the mother was HPA-1a negative and had detectable anti-HPA-1a during pregnancy. Maternal samples from 166 of these pregnancies were rescreened for anti-HLA Class I, revealing 111 (67%) that were antibody positive. Various regression models were used to assess if and how maternal anti-HLA Class I influenced the neonatal platelet count. Results and Conclusions: Unadjusted neonatal platelet counts and the frequency of neonatal thrombocytopenia was not significantly affected by the presence of anti-HLA Class I alongside anti–HPA-1a, but results from regression analyses revealed a possible increased risk when the mother was nulliparous. These results warrant further investigation.</p>}},
author = {{Dahl, Jesper and Skogen, Bjørn and Kjaer, Mette and Husebekk, Anne and Kjeldsen-Kragh, Jens and Tiller, Heidi}},
issn = {{0041-1132}},
language = {{eng}},
month = {{06}},
number = {{9}},
pages = {{2121--2129}},
publisher = {{Wiley-Blackwell}},
series = {{Transfusion}},
title = {{A combined effect of anti-HPA-1a and anti-HLA Class I in pregnancy?}},
url = {{http://dx.doi.org/10.1111/trf.15944}},
doi = {{10.1111/trf.15944}},
volume = {{60}},
year = {{2020}},
}