Advanced

Food intake and meal pattern in IAPP knockout mice with and without infusion of exogenous IAPP

Olsson, Madelene; Herrington, Margery K.; Reidelberger, Roger D.; Permert, Johan; Gebre-Medhin, Samuel LU and Arnelo, Urban (2012) In Scandinavian Journal of Gastroenterology 47(2). p.191-196
Abstract
Objective. The current study used islet amyloid polypeptide (IAPP) knockout mice (KO mice) to investigate the physiological role of IAPP in the regulation of food intake (FI). Material and methods. FI and body weight were measured in KO and wild-type (WT) mice for 27 weeks. In an additional short-term experiment, IAPP (25 pmol . kg(-1)min(-1)) was infused subcutaneously for 3 days in KO and WT mice, and FI, meal pattern, and body weight were analyzed. Results. In the long-term experiment, no significant differences in body weight were seen between WT and KO mice at any point. FI, meal number, and meal size did not differ significantly between the groups in any of the five selected weeks that were studied. In the short-term experiment, FI... (More)
Objective. The current study used islet amyloid polypeptide (IAPP) knockout mice (KO mice) to investigate the physiological role of IAPP in the regulation of food intake (FI). Material and methods. FI and body weight were measured in KO and wild-type (WT) mice for 27 weeks. In an additional short-term experiment, IAPP (25 pmol . kg(-1)min(-1)) was infused subcutaneously for 3 days in KO and WT mice, and FI, meal pattern, and body weight were analyzed. Results. In the long-term experiment, no significant differences in body weight were seen between WT and KO mice at any point. FI, meal number, and meal size did not differ significantly between the groups in any of the five selected weeks that were studied. In the short-term experiment, FI decreased significantly during IAPP infusion in both WT and KO groups. FI was significantly lower in the KO mice compared with WT on days 1 and 2 (p < 0.05 and p < 0.01, respectively). Conclusions. The data showing no differences in FI and body weight were seen between KO and WT mice, indicating that FI can be controlled in the absence of IAPP. The more marked anorectic effect seen in the KO mice during IAPP infusion suggests that IAPP receptors and/or IAPP post-receptor signaling pathways are up-regulated in mice lacking endogenous IAPP. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
body weight, eating, food intake, IAPP knockout mouse, meal pattern, satiety
in
Scandinavian Journal of Gastroenterology
volume
47
issue
2
pages
191 - 196
publisher
Taylor & Francis
external identifiers
  • wos:000299126200009
  • scopus:84856046341
ISSN
1502-7708
DOI
10.3109/00365521.2011.638392
language
English
LU publication?
yes
id
b5f85dc4-b0e6-4a16-89d2-c6804c2136c6 (old id 2355174)
date added to LUP
2012-03-01 11:26:23
date last changed
2017-03-12 03:58:45
@article{b5f85dc4-b0e6-4a16-89d2-c6804c2136c6,
  abstract     = {Objective. The current study used islet amyloid polypeptide (IAPP) knockout mice (KO mice) to investigate the physiological role of IAPP in the regulation of food intake (FI). Material and methods. FI and body weight were measured in KO and wild-type (WT) mice for 27 weeks. In an additional short-term experiment, IAPP (25 pmol . kg(-1)min(-1)) was infused subcutaneously for 3 days in KO and WT mice, and FI, meal pattern, and body weight were analyzed. Results. In the long-term experiment, no significant differences in body weight were seen between WT and KO mice at any point. FI, meal number, and meal size did not differ significantly between the groups in any of the five selected weeks that were studied. In the short-term experiment, FI decreased significantly during IAPP infusion in both WT and KO groups. FI was significantly lower in the KO mice compared with WT on days 1 and 2 (p &lt; 0.05 and p &lt; 0.01, respectively). Conclusions. The data showing no differences in FI and body weight were seen between KO and WT mice, indicating that FI can be controlled in the absence of IAPP. The more marked anorectic effect seen in the KO mice during IAPP infusion suggests that IAPP receptors and/or IAPP post-receptor signaling pathways are up-regulated in mice lacking endogenous IAPP.},
  author       = {Olsson, Madelene and Herrington, Margery K. and Reidelberger, Roger D. and Permert, Johan and Gebre-Medhin, Samuel and Arnelo, Urban},
  issn         = {1502-7708},
  keyword      = {body weight,eating,food intake,IAPP knockout mouse,meal pattern,satiety},
  language     = {eng},
  number       = {2},
  pages        = {191--196},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Food intake and meal pattern in IAPP knockout mice with and without infusion of exogenous IAPP},
  url          = {http://dx.doi.org/10.3109/00365521.2011.638392},
  volume       = {47},
  year         = {2012},
}