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An evaluation of an optimal sampling strategy for meropenem in febrile neutropenics

Ariano, R E; Zelenitsky, S A; Nyhlén, Anna LU and Sitar, D S (2005) In Journal of Clinical Pharmacology 45(7). p.832-835
Abstract
Optimal sampling design with nonparametric population modeling offers the opportunity to determine pharma-cokinetic parameters for patients in whom blood sampling is restricted. This approach was compared to a standard individualized modeling method for meropenem pharmacokinetics in febrile neutropenic patients. The population modeling program, nonparametric approach of expectation maximization (NPEM), with a full data set was compared to a sparse data set selected by D-optimal sampling design. The authors demonstrated that the D-optimal sampling strategy, when applied to this clinical population, provided good pharmacokinetic parameter estimates along with their variability. Four individualized and optimally selected sampling time points... (More)
Optimal sampling design with nonparametric population modeling offers the opportunity to determine pharma-cokinetic parameters for patients in whom blood sampling is restricted. This approach was compared to a standard individualized modeling method for meropenem pharmacokinetics in febrile neutropenic patients. The population modeling program, nonparametric approach of expectation maximization (NPEM), with a full data set was compared to a sparse data set selected by D-optimal sampling design. The authors demonstrated that the D-optimal sampling strategy, when applied to this clinical population, provided good pharmacokinetic parameter estimates along with their variability. Four individualized and optimally selected sampling time points provided the same parameter estimates as more intensive sampling regimens using traditional and population modeling techniques. The different modeling methods were considerably consistent, except for the estimation of CLd with sparse sampling. The findings suggest that D-optimal sparse sampling is a reasonable approach to population pharmacokinetic/pharmacodynamic studies during drug development when limited sampling is necessary. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pharmacokinetics, D-optimal sampling, meropenem, febrile neutropenia
in
Journal of Clinical Pharmacology
volume
45
issue
7
pages
832 - 835
publisher
SAGE Publications Inc.
external identifiers
  • pmid:15951473
  • wos:000230088800010
  • scopus:21044450208
ISSN
0091-2700
DOI
10.1177/0091270005277937
language
English
LU publication?
yes
id
c7b128b6-8063-4bbd-a884-52e4cc0de11a (old id 235669)
date added to LUP
2007-08-02 11:27:17
date last changed
2017-01-01 06:59:37
@article{c7b128b6-8063-4bbd-a884-52e4cc0de11a,
  abstract     = {Optimal sampling design with nonparametric population modeling offers the opportunity to determine pharma-cokinetic parameters for patients in whom blood sampling is restricted. This approach was compared to a standard individualized modeling method for meropenem pharmacokinetics in febrile neutropenic patients. The population modeling program, nonparametric approach of expectation maximization (NPEM), with a full data set was compared to a sparse data set selected by D-optimal sampling design. The authors demonstrated that the D-optimal sampling strategy, when applied to this clinical population, provided good pharmacokinetic parameter estimates along with their variability. Four individualized and optimally selected sampling time points provided the same parameter estimates as more intensive sampling regimens using traditional and population modeling techniques. The different modeling methods were considerably consistent, except for the estimation of CLd with sparse sampling. The findings suggest that D-optimal sparse sampling is a reasonable approach to population pharmacokinetic/pharmacodynamic studies during drug development when limited sampling is necessary.},
  author       = {Ariano, R E and Zelenitsky, S A and Nyhlén, Anna and Sitar, D S},
  issn         = {0091-2700},
  keyword      = {pharmacokinetics,D-optimal sampling,meropenem,febrile neutropenia},
  language     = {eng},
  number       = {7},
  pages        = {832--835},
  publisher    = {SAGE Publications Inc.},
  series       = {Journal of Clinical Pharmacology},
  title        = {An evaluation of an optimal sampling strategy for meropenem in febrile neutropenics},
  url          = {http://dx.doi.org/10.1177/0091270005277937},
  volume       = {45},
  year         = {2005},
}