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Lipid emboli distribution in cardiac surgery is dependent on the state of emulsification

Eyjolfsson, Atli LU ; Dencker, Magnus LU ; Brondén, Björn LU ; Scicluna, Sara LU ; Johnsson, Per and Bjursten, Henrik LU (2012) In Scandinavian Cardiovascular Journal 46(1). p.51-56
Abstract
Objective. Lipid embolizations from retransfused shed blood during cardiac surgery have been shown to enter the circulation and end up in different organs. The purpose of this investigation was to evaluate differences in the kinetics and deposition between emulsified and non-emulsified lipid emboli in a porcine model. Design. Twelve animals were anesthetized and put on cardiopulmonary bypass. A shed-blood phantom (6 animals given emulsified and 6 given non-emulsified lipids) was produced from arterial blood, saline, and tritium-labeled triolein. The phantom was infused into the cardiopulmonary bypass circuit. Arterial and venous blood samples were taken at short intervals. Tissue samples were taken post-mortem from examined organs and... (More)
Objective. Lipid embolizations from retransfused shed blood during cardiac surgery have been shown to enter the circulation and end up in different organs. The purpose of this investigation was to evaluate differences in the kinetics and deposition between emulsified and non-emulsified lipid emboli in a porcine model. Design. Twelve animals were anesthetized and put on cardiopulmonary bypass. A shed-blood phantom (6 animals given emulsified and 6 given non-emulsified lipids) was produced from arterial blood, saline, and tritium-labeled triolein. The phantom was infused into the cardiopulmonary bypass circuit. Arterial and venous blood samples were taken at short intervals. Tissue samples were taken post-mortem from examined organs and prepared for scintillation counting. Levels of radioactivity were used to measure lipid emboli content in blood and tissue. Results. Emulsified lipid emboli generated a 5-fold higher embolic load in the arterial and a 12-fold higher in the venous circulation, compared with non-emulsified lipid emboli. Emulsified lipid micro emboli resulted in a 2-15-fold higher tissue deposition in investigated organs compared with non-emulsified lipid micro emboli. Conclusions. This study shows that the state of emulsion significantly alter the kinetics and tissue deposition of lipid emboli. Emulsified lipid emboli give higher embolic load in the arterial and venous circulation, and higher tissue deposition versus non-emulsified lipid emboli. In both groups, the embolic load was higher in the arterial circulation than on the venous side. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lipid emboli, emulsification, porcine, radioactive
in
Scandinavian Cardiovascular Journal
volume
46
issue
1
pages
51 - 56
publisher
Taylor & Francis
external identifiers
  • wos:000298748100008
  • scopus:84855361717
ISSN
1651-2006
DOI
10.3109/14017431.2011.638985
language
English
LU publication?
yes
id
890798c1-cb6e-4830-88b3-bbe567369e65 (old id 2358531)
date added to LUP
2012-03-01 11:29:19
date last changed
2017-01-01 06:01:09
@article{890798c1-cb6e-4830-88b3-bbe567369e65,
  abstract     = {Objective. Lipid embolizations from retransfused shed blood during cardiac surgery have been shown to enter the circulation and end up in different organs. The purpose of this investigation was to evaluate differences in the kinetics and deposition between emulsified and non-emulsified lipid emboli in a porcine model. Design. Twelve animals were anesthetized and put on cardiopulmonary bypass. A shed-blood phantom (6 animals given emulsified and 6 given non-emulsified lipids) was produced from arterial blood, saline, and tritium-labeled triolein. The phantom was infused into the cardiopulmonary bypass circuit. Arterial and venous blood samples were taken at short intervals. Tissue samples were taken post-mortem from examined organs and prepared for scintillation counting. Levels of radioactivity were used to measure lipid emboli content in blood and tissue. Results. Emulsified lipid emboli generated a 5-fold higher embolic load in the arterial and a 12-fold higher in the venous circulation, compared with non-emulsified lipid emboli. Emulsified lipid micro emboli resulted in a 2-15-fold higher tissue deposition in investigated organs compared with non-emulsified lipid micro emboli. Conclusions. This study shows that the state of emulsion significantly alter the kinetics and tissue deposition of lipid emboli. Emulsified lipid emboli give higher embolic load in the arterial and venous circulation, and higher tissue deposition versus non-emulsified lipid emboli. In both groups, the embolic load was higher in the arterial circulation than on the venous side.},
  author       = {Eyjolfsson, Atli and Dencker, Magnus and Brondén, Björn and Scicluna, Sara and Johnsson, Per and Bjursten, Henrik},
  issn         = {1651-2006},
  keyword      = {lipid emboli,emulsification,porcine,radioactive},
  language     = {eng},
  number       = {1},
  pages        = {51--56},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal},
  title        = {Lipid emboli distribution in cardiac surgery is dependent on the state of emulsification},
  url          = {http://dx.doi.org/10.3109/14017431.2011.638985},
  volume       = {46},
  year         = {2012},
}