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Increased risk of asthma attacks and emergency visits among asthma patients with allergic rhinitis: a subgroup analysis of the improving asthma control trial

Bousquet, J; Gaugris, S; Kocevar, VS; Zhang, Q; Yin, DD; Polos, PG and Bjermer, Leif LU (2005) In Clinical and Experimental Allergy 35(6). p.723-727
Abstract
Background Inadequately controlled allergic rhinitis (AR) in asthmatic patients can contribute towards increased asthma exacerbations and poorer symptom control, which may increase medical resource use. We assessed asthma-related medical resource use and attacks in asthmatic patients who did and did not have concomitant AR and were adding montelukast or salmeterol to baseline treatment with inhaled. fluticasone. Methods A post hoc resource use analysis of a 52-week, double-blind multicentre clinical trial (IMPACT: IMProving Asthma Control Trial) including 1490 adults with chronic asthma, aged 15 72 years, with FEV1 50-90% of predicted and >= 12% increase in FEV1 after salbutamol administration, treated with either montelukast 10mg daily... (More)
Background Inadequately controlled allergic rhinitis (AR) in asthmatic patients can contribute towards increased asthma exacerbations and poorer symptom control, which may increase medical resource use. We assessed asthma-related medical resource use and attacks in asthmatic patients who did and did not have concomitant AR and were adding montelukast or salmeterol to baseline treatment with inhaled. fluticasone. Methods A post hoc resource use analysis of a 52-week, double-blind multicentre clinical trial (IMPACT: IMProving Asthma Control Trial) including 1490 adults with chronic asthma, aged 15 72 years, with FEV1 50-90% of predicted and >= 12% increase in FEV1 after salbutamol administration, treated with either montelukast 10mg daily or salmeterol 50 mu g twice daily in addition to. fluticasone 200 mg, was undertaken. Asthma- related medical resource use included medical visits ( defined as either an unscheduled visit [to a general practitioner, a specialist or a nonmedical provider] or a specialist visit), emergency room visits and hospitalizations during follow-up. Asthma attacks were defined as the worsening of asthma requiring unscheduled visit, emergency visit, hospitalization or oral/intravenous/intramuscular corticosteroids. Results A self-reported history of concomitant AR was identified in 60% of the patients (n=893). Univariate analysis suggests that significantly more patients with concomitant AR experienced emergency room visits (3.6% vs. 1.7%, P=0.029) and asthma attacks (21.3% vs. 17.1%, P=0.046). Multivariate analysis adjusting for treatment group, age and baseline asthma severity confirmed these results since the presence of concomitant AR in patients with asthma increases the likelihood of emergency room visit ( odds ratio ( OR) 52.35, 95% confidence interval (CI) = 1.12 - 4.80) and asthma attack (OR = 1.35, 95% CI = 1.03 - 1.77). Patients with asthma alone compared with patients with both conditions did not differ in terms of unscheduled or specialist visits and hospitalizations. Conclusions Presence of self-reported concomitant AR in patients with asthma resulted in a higher rate of asthma attacks and more emergency room visits compared with asthma patients without concomitant AR. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
resource utilization, attack, allergic rhinitis, asthma
in
Clinical and Experimental Allergy
volume
35
issue
6
pages
723 - 727
publisher
Wiley-Blackwell
external identifiers
  • wos:000229956100008
  • pmid:15969661
  • scopus:21844431891
ISSN
1365-2222
DOI
10.1111/j.1365-2222.2005.02251.x
language
English
LU publication?
yes
id
7175758c-5fb3-4377-a717-e1106c55698a (old id 235878)
date added to LUP
2007-08-15 09:16:59
date last changed
2017-10-22 03:38:19
@article{7175758c-5fb3-4377-a717-e1106c55698a,
  abstract     = {Background Inadequately controlled allergic rhinitis (AR) in asthmatic patients can contribute towards increased asthma exacerbations and poorer symptom control, which may increase medical resource use. We assessed asthma-related medical resource use and attacks in asthmatic patients who did and did not have concomitant AR and were adding montelukast or salmeterol to baseline treatment with inhaled. fluticasone. Methods A post hoc resource use analysis of a 52-week, double-blind multicentre clinical trial (IMPACT: IMProving Asthma Control Trial) including 1490 adults with chronic asthma, aged 15 72 years, with FEV1 50-90% of predicted and >= 12% increase in FEV1 after salbutamol administration, treated with either montelukast 10mg daily or salmeterol 50 mu g twice daily in addition to. fluticasone 200 mg, was undertaken. Asthma- related medical resource use included medical visits ( defined as either an unscheduled visit [to a general practitioner, a specialist or a nonmedical provider] or a specialist visit), emergency room visits and hospitalizations during follow-up. Asthma attacks were defined as the worsening of asthma requiring unscheduled visit, emergency visit, hospitalization or oral/intravenous/intramuscular corticosteroids. Results A self-reported history of concomitant AR was identified in 60% of the patients (n=893). Univariate analysis suggests that significantly more patients with concomitant AR experienced emergency room visits (3.6% vs. 1.7%, P=0.029) and asthma attacks (21.3% vs. 17.1%, P=0.046). Multivariate analysis adjusting for treatment group, age and baseline asthma severity confirmed these results since the presence of concomitant AR in patients with asthma increases the likelihood of emergency room visit ( odds ratio ( OR) 52.35, 95% confidence interval (CI) = 1.12 - 4.80) and asthma attack (OR = 1.35, 95% CI = 1.03 - 1.77). Patients with asthma alone compared with patients with both conditions did not differ in terms of unscheduled or specialist visits and hospitalizations. Conclusions Presence of self-reported concomitant AR in patients with asthma resulted in a higher rate of asthma attacks and more emergency room visits compared with asthma patients without concomitant AR.},
  author       = {Bousquet, J and Gaugris, S and Kocevar, VS and Zhang, Q and Yin, DD and Polos, PG and Bjermer, Leif},
  issn         = {1365-2222},
  keyword      = {resource utilization,attack,allergic rhinitis,asthma},
  language     = {eng},
  number       = {6},
  pages        = {723--727},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical and Experimental Allergy},
  title        = {Increased risk of asthma attacks and emergency visits among asthma patients with allergic rhinitis: a subgroup analysis of the improving asthma control trial},
  url          = {http://dx.doi.org/10.1111/j.1365-2222.2005.02251.x},
  volume       = {35},
  year         = {2005},
}