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Skin morphology and layer identification using different STIM geometries

Aguer, P; Alves, LC; Barberet, P; Gontier, E; Incerti, S; Michelet-Habchi, C; Kertesz, Z; Kiss, AZ; Moretto, P and Pallon, Jan LU , et al. (2005) In Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 231(1-4). p.292-299
Abstract
The use of on-axis geometry in scanning transmission ion microscopy (STIM) has been widely used for thin biological sample structure identification. In this configuration, the lateral resolution is optimised so that micron or submicron beam spots are easily achieved even for classic microbeam lines. Off-axis STIM was more particularly employed for rapid imaging, and also (when associated to a scattering set-up) for normalising elemental contents obtained by other ion beam analysis techniques in organic thin samples. Due to the very small beam current required, on-axis STIM is a stand-alone technique. Off-axis STIM can be advantageous as it enables the simultaneous utilisation of PIXE and RBS techniques. In this paper, the STIM images... (More)
The use of on-axis geometry in scanning transmission ion microscopy (STIM) has been widely used for thin biological sample structure identification. In this configuration, the lateral resolution is optimised so that micron or submicron beam spots are easily achieved even for classic microbeam lines. Off-axis STIM was more particularly employed for rapid imaging, and also (when associated to a scattering set-up) for normalising elemental contents obtained by other ion beam analysis techniques in organic thin samples. Due to the very small beam current required, on-axis STIM is a stand-alone technique. Off-axis STIM can be advantageous as it enables the simultaneous utilisation of PIXE and RBS techniques. In this paper, the STIM images obtained with an on-axis geometry, a standard off-axis geometry and a recently developed on-off geometry are presented and discussed. Data from skin samples are used for comparison purposes aiming at studying skin permeability to sunscreens. Skin is a stratified tissue and the precise identification of skin layers is needed to ascertain the penetration depth of the physical filter from the formulation. In addition to the intrinsic difference in image quality due to the beam resolution, the influence of the detector type, implanted silicon detector versus Si pin diode, is discussed on the basis of their energy resolution.. their resistance to beam damage as well as the effect (Less)
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published
subject
keywords
beam damage, image quality, STIM
in
Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
volume
231
issue
1-4
pages
292 - 299
publisher
Elsevier
external identifiers
  • wos:000229752400050
  • scopus:33644608770
ISSN
0168-583X
DOI
10.1016/j.nimb.2005.01.073
language
English
LU publication?
yes
id
d78a4e87-3636-4056-aa92-d95078154041 (old id 236049)
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2007-08-24 09:50:19
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2017-09-10 04:31:22
@article{d78a4e87-3636-4056-aa92-d95078154041,
  abstract     = {The use of on-axis geometry in scanning transmission ion microscopy (STIM) has been widely used for thin biological sample structure identification. In this configuration, the lateral resolution is optimised so that micron or submicron beam spots are easily achieved even for classic microbeam lines. Off-axis STIM was more particularly employed for rapid imaging, and also (when associated to a scattering set-up) for normalising elemental contents obtained by other ion beam analysis techniques in organic thin samples. Due to the very small beam current required, on-axis STIM is a stand-alone technique. Off-axis STIM can be advantageous as it enables the simultaneous utilisation of PIXE and RBS techniques. In this paper, the STIM images obtained with an on-axis geometry, a standard off-axis geometry and a recently developed on-off geometry are presented and discussed. Data from skin samples are used for comparison purposes aiming at studying skin permeability to sunscreens. Skin is a stratified tissue and the precise identification of skin layers is needed to ascertain the penetration depth of the physical filter from the formulation. In addition to the intrinsic difference in image quality due to the beam resolution, the influence of the detector type, implanted silicon detector versus Si pin diode, is discussed on the basis of their energy resolution.. their resistance to beam damage as well as the effect},
  author       = {Aguer, P and Alves, LC and Barberet, P and Gontier, E and Incerti, S and Michelet-Habchi, C and Kertesz, Z and Kiss, AZ and Moretto, P and Pallon, Jan and Pinheiro, T and Surleve-Bazeille, JE and Szikszai, Z and Verissimo, A and Ynsa, MD},
  issn         = {0168-583X},
  keyword      = {beam damage,image quality,STIM},
  language     = {eng},
  number       = {1-4},
  pages        = {292--299},
  publisher    = {Elsevier},
  series       = {Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms},
  title        = {Skin morphology and layer identification using different STIM geometries},
  url          = {http://dx.doi.org/10.1016/j.nimb.2005.01.073},
  volume       = {231},
  year         = {2005},
}