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Vibratory perception threshold in young and middle-aged patients at high risk of knee osteoarthritis compared to controls

Thorlund, Jonas Bloch; Shakoor, Najia; Ageberg, Eva LU ; Sandal, Louise Fleng; Block, Joel A. and Roos, Ewa LU (2012) In Arthritis Care and Research1988-01-01+01:002000-01-01+01:00 64(1). p.144-148
Abstract
Objective Vibratory perception threshold (VPT) is impaired in patients with knee osteoarthritis (OA). It is, however, not known if sensory deficits precede or follow as a consequence of OA. The aim of this study was to investigate VPT in 2 independent groups of patients with high risk of future OA (young anterior cruciate ligament [ACL]-injured patients and middle-aged meniscectomized patients) and compare them to age-matched controls. Methods. VPT was assessed at the medial malleolus (MM) and medial femoral condyle (MFC) in 2 independent groups of patients and matched controls: ACL- injured patients (n = 39, mean +/- SD age 24.0 +/- 5.2 years, mean +/- SD BMI 24.0 +/- 2.9 kg/m(2), mean +/- SD time since injury 21.9 +/- 21.6 months) and... (More)
Objective Vibratory perception threshold (VPT) is impaired in patients with knee osteoarthritis (OA). It is, however, not known if sensory deficits precede or follow as a consequence of OA. The aim of this study was to investigate VPT in 2 independent groups of patients with high risk of future OA (young anterior cruciate ligament [ACL]-injured patients and middle-aged meniscectomized patients) and compare them to age-matched controls. Methods. VPT was assessed at the medial malleolus (MM) and medial femoral condyle (MFC) in 2 independent groups of patients and matched controls: ACL- injured patients (n = 39, mean +/- SD age 24.0 +/- 5.2 years, mean +/- SD BMI 24.0 +/- 2.9 kg/m(2), mean +/- SD time since injury 21.9 +/- 21.6 months) and controls (n = 28, mean +/- SD age 25.6 +/- 4.4 years, mean +/- SD BMI 23.6 +/- 2.2 kg/m(2)), and meniscectomized patients (n = 22, mean +/- SD age 49.6 +/- 4.8 years, mean +/- SD BMI 24.7 +/- 2.7 kg/m(2), mean +/- SD time since surgery 49.6 +/- 5.0 months) and controls (n = 25, mean +/- SD age 49.4 +/- 5.2 years, mean +/- SD BMI 25.2 +/- 4.9 kg/m(2)). Results. ACL- injured patients had a better VPT than controls at the MM (P = 0.030), which persisted after adjusting for age and sex (P = 0.034). At the MFC, there was a similar trend in favor of ACL injured patients (unadjusted P = 0.093, adjusted P = 0.122). No differences were seen in VPT at theMMbetween meniscectomized patients and controls, whereas there was a tendency for better VPT in meniscectomized patients at the MFC (unadjusted P = 0.085, adjusted P = 0.092). Conclusion. Impaired vibratory sensation could not be confirmed in 2 independent groups of patients compared to age-matched controls, suggesting that impaired vibratory sense is not present in knee- injured patients at high risk or in the very early phase of knee OA. (Less)
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Contribution to journal
publication status
published
subject
in
Arthritis Care and Research1988-01-01+01:002000-01-01+01:00
volume
64
issue
1
pages
144 - 148
publisher
John Wiley & Sons
external identifiers
  • wos:000298536700022
  • scopus:84856879040
ISSN
2151-4658
DOI
10.1002/acr.20624
language
English
LU publication?
yes
id
f607b43f-c09c-4414-887e-19381f83c1bb (old id 2362509)
date added to LUP
2012-02-22 14:28:00
date last changed
2017-08-20 03:11:12
@article{f607b43f-c09c-4414-887e-19381f83c1bb,
  abstract     = {Objective Vibratory perception threshold (VPT) is impaired in patients with knee osteoarthritis (OA). It is, however, not known if sensory deficits precede or follow as a consequence of OA. The aim of this study was to investigate VPT in 2 independent groups of patients with high risk of future OA (young anterior cruciate ligament [ACL]-injured patients and middle-aged meniscectomized patients) and compare them to age-matched controls. Methods. VPT was assessed at the medial malleolus (MM) and medial femoral condyle (MFC) in 2 independent groups of patients and matched controls: ACL- injured patients (n = 39, mean +/- SD age 24.0 +/- 5.2 years, mean +/- SD BMI 24.0 +/- 2.9 kg/m(2), mean +/- SD time since injury 21.9 +/- 21.6 months) and controls (n = 28, mean +/- SD age 25.6 +/- 4.4 years, mean +/- SD BMI 23.6 +/- 2.2 kg/m(2)), and meniscectomized patients (n = 22, mean +/- SD age 49.6 +/- 4.8 years, mean +/- SD BMI 24.7 +/- 2.7 kg/m(2), mean +/- SD time since surgery 49.6 +/- 5.0 months) and controls (n = 25, mean +/- SD age 49.4 +/- 5.2 years, mean +/- SD BMI 25.2 +/- 4.9 kg/m(2)). Results. ACL- injured patients had a better VPT than controls at the MM (P = 0.030), which persisted after adjusting for age and sex (P = 0.034). At the MFC, there was a similar trend in favor of ACL injured patients (unadjusted P = 0.093, adjusted P = 0.122). No differences were seen in VPT at theMMbetween meniscectomized patients and controls, whereas there was a tendency for better VPT in meniscectomized patients at the MFC (unadjusted P = 0.085, adjusted P = 0.092). Conclusion. Impaired vibratory sensation could not be confirmed in 2 independent groups of patients compared to age-matched controls, suggesting that impaired vibratory sense is not present in knee- injured patients at high risk or in the very early phase of knee OA.},
  author       = {Thorlund, Jonas Bloch and Shakoor, Najia and Ageberg, Eva and Sandal, Louise Fleng and Block, Joel A. and Roos, Ewa},
  issn         = {2151-4658},
  language     = {eng},
  number       = {1},
  pages        = {144--148},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis Care and Research1988-01-01+01:002000-01-01+01:00},
  title        = {Vibratory perception threshold in young and middle-aged patients at high risk of knee osteoarthritis compared to controls},
  url          = {http://dx.doi.org/10.1002/acr.20624},
  volume       = {64},
  year         = {2012},
}