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Ventricular repolarization sequences on the epicardium and endocardium. Monophasic action potential mapping in healthy pigs

Kongstad Rasmussen, Ole LU ; Xia, Yunlong LU ; Liu, Ying LU ; Liang, Yanchun; Olsson, Bertil LU and Yuan, Shiwen LU (2012) In Journal of Electrocardiology 45(1). p.49-56
Abstract
To investigate repolarization sequence, monophasic action potentials were recorded from a mean of 153 +/- 54 left and right ventricular epicardial and endocardial sites in 10 pigs using the CARTO mapping system (Biosense Webster, Waterloo, Belgium). The activation time and end-of-repolarization (EOR) time were measured and 3-dimensional maps of activation and repolarization sequences constructed. Results: In 8 of 9 pigs, both the activation and EOR times appeared first in the septum and last in the latero-basal areas on the endocardium, not on the epicardium. The EOR followed the activation sequence, both on the epicardium (in 8/9 pigs) and endocardium (in 8/8 pigs). The maximal EOR differences were 84 +/- 20 ms, whereas the local EOR... (More)
To investigate repolarization sequence, monophasic action potentials were recorded from a mean of 153 +/- 54 left and right ventricular epicardial and endocardial sites in 10 pigs using the CARTO mapping system (Biosense Webster, Waterloo, Belgium). The activation time and end-of-repolarization (EOR) time were measured and 3-dimensional maps of activation and repolarization sequences constructed. Results: In 8 of 9 pigs, both the activation and EOR times appeared first in the septum and last in the latero-basal areas on the endocardium, not on the epicardium. The EOR followed the activation sequence, both on the epicardium (in 8/9 pigs) and endocardium (in 8/8 pigs). The maximal EOR differences were 84 +/- 20 ms, whereas the local EOR differences between paired sites against each other on the tell ventricular epicardium and endocardium were 11 +/- 9 ms in the apex and 12 +/- 12 ms in the anterior wall. Conclusion: The EOR follows the activation sequence both on the epicardium and endocardium. The apico-basal gradients are predominant repolarization gradients, as compared with the epicardial-endocardial gradients. (C) 2012 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Repolarization sequence, Epicardium, Endocardium, Ventricle, Monophasic, action potential
in
Journal of Electrocardiology
volume
45
issue
1
pages
49 - 56
publisher
Elsevier
external identifiers
  • wos:000298871900011
  • scopus:84855314776
ISSN
1532-8430
DOI
10.1016/j.jelectrocard.2011.04.009
language
English
LU publication?
yes
id
7aa643fe-65fb-4a17-aef5-235952b28752 (old id 2362561)
date added to LUP
2012-03-01 12:12:12
date last changed
2017-01-01 03:31:38
@article{7aa643fe-65fb-4a17-aef5-235952b28752,
  abstract     = {To investigate repolarization sequence, monophasic action potentials were recorded from a mean of 153 +/- 54 left and right ventricular epicardial and endocardial sites in 10 pigs using the CARTO mapping system (Biosense Webster, Waterloo, Belgium). The activation time and end-of-repolarization (EOR) time were measured and 3-dimensional maps of activation and repolarization sequences constructed. Results: In 8 of 9 pigs, both the activation and EOR times appeared first in the septum and last in the latero-basal areas on the endocardium, not on the epicardium. The EOR followed the activation sequence, both on the epicardium (in 8/9 pigs) and endocardium (in 8/8 pigs). The maximal EOR differences were 84 +/- 20 ms, whereas the local EOR differences between paired sites against each other on the tell ventricular epicardium and endocardium were 11 +/- 9 ms in the apex and 12 +/- 12 ms in the anterior wall. Conclusion: The EOR follows the activation sequence both on the epicardium and endocardium. The apico-basal gradients are predominant repolarization gradients, as compared with the epicardial-endocardial gradients. (C) 2012 Elsevier Inc. All rights reserved.},
  author       = {Kongstad Rasmussen, Ole and Xia, Yunlong and Liu, Ying and Liang, Yanchun and Olsson, Bertil and Yuan, Shiwen},
  issn         = {1532-8430},
  keyword      = {Repolarization sequence,Epicardium,Endocardium,Ventricle,Monophasic,action potential},
  language     = {eng},
  number       = {1},
  pages        = {49--56},
  publisher    = {Elsevier},
  series       = {Journal of Electrocardiology},
  title        = {Ventricular repolarization sequences on the epicardium and endocardium. Monophasic action potential mapping in healthy pigs},
  url          = {http://dx.doi.org/10.1016/j.jelectrocard.2011.04.009},
  volume       = {45},
  year         = {2012},
}