Advanced

Occupational risks for uveal melanoma results from a case-control study in nine European countries

Lutz, JM; Cree, I; Sabroe, S; Kvist, TK; Clausen, LB; Afonso, N; Ahrens, W; Ballard, TJ; Bell, J and Cyr, D, et al. (2005) In Cancer Causes and Control 16(4). p.437-447
Abstract
Objective Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors. Methods A population based case-control study was undertaken during 1995-1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job exposure matrix. In total, 320 uveal melanoma cases were eligible at pathology review, and 292 cases were interviewed, participation 91%. Out of 3357 population controls, 2062 were interviewed, 61%, and out of 1272 cancer controls 1094 were interviewed, 86%. Results Using population controls, occupational exposure to sunlight was not associated... (More)
Objective Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors. Methods A population based case-control study was undertaken during 1995-1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job exposure matrix. In total, 320 uveal melanoma cases were eligible at pathology review, and 292 cases were interviewed, participation 91%. Out of 3357 population controls, 2062 were interviewed, 61%, and out of 1272 cancer controls 1094 were interviewed, 86%. Results Using population controls, occupational exposure to sunlight was not associated with an increased risk (RR=1.24, 95% CI=0.88-1.74), while an excess risk found with use of colon cancer controls was attributed to confounding factors. An excess risk in welders was restricted to the French part of the data. Cooks, RR=2.40; cleaners, RR 2.15; and laundry workers, RR=3.14, were at increased risk of uveal melanoma. Conclusion Our study does overall not support an association between occupational sunlight exposure and risk of uveal melanoma. The finding of an excess risk of eye melanoma in cooks in several European countries is intriguing. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
case-control study, eye, Malignant melanoma
in
Cancer Causes and Control
volume
16
issue
4
pages
437 - 447
publisher
Springer
external identifiers
  • wos:000229803000012
  • pmid:15953986
  • scopus:21244442007
ISSN
1573-7225
DOI
10.1007/s10552-004-5029-6
language
English
LU publication?
yes
id
821e3359-8fd2-4453-be58-99e9d55168aa (old id 236292)
date added to LUP
2007-08-21 08:41:39
date last changed
2017-10-22 03:56:31
@article{821e3359-8fd2-4453-be58-99e9d55168aa,
  abstract     = {Objective Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors. Methods A population based case-control study was undertaken during 1995-1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job exposure matrix. In total, 320 uveal melanoma cases were eligible at pathology review, and 292 cases were interviewed, participation 91%. Out of 3357 population controls, 2062 were interviewed, 61%, and out of 1272 cancer controls 1094 were interviewed, 86%. Results Using population controls, occupational exposure to sunlight was not associated with an increased risk (RR=1.24, 95% CI=0.88-1.74), while an excess risk found with use of colon cancer controls was attributed to confounding factors. An excess risk in welders was restricted to the French part of the data. Cooks, RR=2.40; cleaners, RR 2.15; and laundry workers, RR=3.14, were at increased risk of uveal melanoma. Conclusion Our study does overall not support an association between occupational sunlight exposure and risk of uveal melanoma. The finding of an excess risk of eye melanoma in cooks in several European countries is intriguing.},
  author       = {Lutz, JM and Cree, I and Sabroe, S and Kvist, TK and Clausen, LB and Afonso, N and Ahrens, W and Ballard, TJ and Bell, J and Cyr, D and Eriksson, Mikael and Fevotte, J and Guenel, P and Hardell, L and Jockel, KH and Miranda, A and Merletti, F and Morales-Suarez-Varela, MM and Stengrevics, A and Lynge, E},
  issn         = {1573-7225},
  keyword      = {case-control study,eye,Malignant melanoma},
  language     = {eng},
  number       = {4},
  pages        = {437--447},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Occupational risks for uveal melanoma results from a case-control study in nine European countries},
  url          = {http://dx.doi.org/10.1007/s10552-004-5029-6},
  volume       = {16},
  year         = {2005},
}