Advanced

Understanding Drug Uptake and Binding within Targeted Disease Micro-Environments in Patients: A New Tool for Translational Medicine

Marko-Varga, György LU ; Végvári, Ákos LU ; Rezeli, Melinda LU ; Prikk, Kaiu; Ross, Peeter; Dahlbäck, Magnus; Edula, Goutham; Sepper, Ruth and Fehniger, Thomas LU (2012) In Clinical and Translational Medicine 1.
Abstract
For many common global diseases, such as cancer, diabetes, neurodegenerative and cardiovascular diseases there is an unmet need for diagnosing early indications of disease that could enable medical intervention and early treatment. For example, cigarette smoking causes a variety of deadly diseases including lung cancer, hypertension, chronic obstructive pulmonary disease (COPD) and cardiovascular diseases. The treatment of these diseases will require detailed knowledge of targeted pathways involved in disease pathogenesis but also the mode of drug actions at the biological location on these targets. New methods, such as matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) are ready to provide insights into the... (More)
For many common global diseases, such as cancer, diabetes, neurodegenerative and cardiovascular diseases there is an unmet need for diagnosing early indications of disease that could enable medical intervention and early treatment. For example, cigarette smoking causes a variety of deadly diseases including lung cancer, hypertension, chronic obstructive pulmonary disease (COPD) and cardiovascular diseases. The treatment of these diseases will require detailed knowledge of targeted pathways involved in disease pathogenesis but also the mode of drug actions at the biological location on these targets. New methods, such as matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) are ready to provide insights into the fate (destinations and distributions) of administered drugs. Translational medicine is a new area of research where expert from different disciplines involved in basic science and clinical disciplines meet and join forces. The ultimate goal is to identify bridging comprehension that forms a knowledge base that can be used by society to develop a better treatment and medicine for patients. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical and Translational Medicine
volume
1
publisher
Springer
ISSN
2001-1326
DOI
10.1186/2001-1326-1-8
language
English
LU publication?
yes
id
d5e4350a-428e-44dc-8244-d2c5696653be (old id 2364961)
date added to LUP
2012-06-04 14:18:08
date last changed
2016-09-20 04:15:46
@article{d5e4350a-428e-44dc-8244-d2c5696653be,
  abstract     = {For many common global diseases, such as cancer, diabetes, neurodegenerative and cardiovascular diseases there is an unmet need for diagnosing early indications of disease that could enable medical intervention and early treatment. For example, cigarette smoking causes a variety of deadly diseases including lung cancer, hypertension, chronic obstructive pulmonary disease (COPD) and cardiovascular diseases. The treatment of these diseases will require detailed knowledge of targeted pathways involved in disease pathogenesis but also the mode of drug actions at the biological location on these targets. New methods, such as matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) are ready to provide insights into the fate (destinations and distributions) of administered drugs. Translational medicine is a new area of research where expert from different disciplines involved in basic science and clinical disciplines meet and join forces. The ultimate goal is to identify bridging comprehension that forms a knowledge base that can be used by society to develop a better treatment and medicine for patients.},
  articleno    = {8},
  author       = {Marko-Varga, György and Végvári, Ákos and Rezeli, Melinda and Prikk, Kaiu and Ross, Peeter and Dahlbäck, Magnus and Edula, Goutham and Sepper, Ruth and Fehniger, Thomas},
  issn         = {2001-1326},
  language     = {eng},
  publisher    = {Springer},
  series       = {Clinical and Translational Medicine},
  title        = {Understanding Drug Uptake and Binding within Targeted Disease Micro-Environments in Patients: A New Tool for Translational Medicine},
  url          = {http://dx.doi.org/10.1186/2001-1326-1-8},
  volume       = {1},
  year         = {2012},
}