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Blood Pressure and Risk of Cancer Incidence and Mortality in the Metabolic Syndrome and Cancer Project.

Stocks, Tanja; Van Hemelrijck, Mieke; Manjer, Jonas LU ; Bjørge, Tone; Ulmer, Hanno; Hallmans, Göran; Lindkvist, Björn LU ; Selmer, Randi; Nagel, Gabriele and Tretli, Steinar, et al. (2012) In Hypertension 59(4). p.135-802
Abstract
Observational studies have shown inconsistent results for the association between blood pressure and cancer risk. We investigated the association in 7 cohorts from Norway, Austria, and Sweden. In total, 577799 adults with a mean age of 44 years were followed for, on average, 12 years. Incident cancers were 22184 in men and 14744 in women, and cancer deaths were 8724 and 4525, respectively. Cox regression was used to calculate hazard ratios of cancer per 10-mm Hg increments of midblood pressure, which corresponded with 0.7 SDs and, for example, an increment of systolic/diastolic blood pressure of 130/80 to 142/88 mm Hg. All of the models used age as the time scale and were adjusted for possible confounders, including body mass index and... (More)
Observational studies have shown inconsistent results for the association between blood pressure and cancer risk. We investigated the association in 7 cohorts from Norway, Austria, and Sweden. In total, 577799 adults with a mean age of 44 years were followed for, on average, 12 years. Incident cancers were 22184 in men and 14744 in women, and cancer deaths were 8724 and 4525, respectively. Cox regression was used to calculate hazard ratios of cancer per 10-mm Hg increments of midblood pressure, which corresponded with 0.7 SDs and, for example, an increment of systolic/diastolic blood pressure of 130/80 to 142/88 mm Hg. All of the models used age as the time scale and were adjusted for possible confounders, including body mass index and smoking status. In men, midblood pressure was positively related to total incident cancer (hazard ratio per 10 mm Hg increment: 1.07 [95% CI: 1.04-1.09]) and to cancer of the oropharynx, colon, rectum, lung, bladder, kidney, malignant melanoma, and nonmelanoma skin cancer. In women, midblood pressure was not related to total incident cancer but was positively related to cancer of the liver, pancreas, cervix, uterine corpus, and malignant melanoma. A positive association was also found for cancer mortality, with HRs per 10-mm Hg increment of 1.12 (95% CI: 1.08-1.15) for men and 1.06 (95% CI: 1.02-1.11) for women. These results suggest a small increased cancer risk overall in men with elevated blood pressure level and a higher risk for cancer death in men and women. (Less)
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organization
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Contribution to journal
publication status
published
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in
Hypertension
volume
59
issue
4
pages
135 - 802
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000301716100021
  • pmid:22353615
  • scopus:84858698428
ISSN
1524-4563
DOI
10.1161/HYPERTENSIONAHA.111.189258
language
English
LU publication?
yes
id
c7f68368-c065-473c-b882-87ca4ccb6639 (old id 2366402)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22353615?dopt=Abstract
date added to LUP
2012-03-02 13:19:07
date last changed
2017-10-01 04:59:03
@article{c7f68368-c065-473c-b882-87ca4ccb6639,
  abstract     = {Observational studies have shown inconsistent results for the association between blood pressure and cancer risk. We investigated the association in 7 cohorts from Norway, Austria, and Sweden. In total, 577799 adults with a mean age of 44 years were followed for, on average, 12 years. Incident cancers were 22184 in men and 14744 in women, and cancer deaths were 8724 and 4525, respectively. Cox regression was used to calculate hazard ratios of cancer per 10-mm Hg increments of midblood pressure, which corresponded with 0.7 SDs and, for example, an increment of systolic/diastolic blood pressure of 130/80 to 142/88 mm Hg. All of the models used age as the time scale and were adjusted for possible confounders, including body mass index and smoking status. In men, midblood pressure was positively related to total incident cancer (hazard ratio per 10 mm Hg increment: 1.07 [95% CI: 1.04-1.09]) and to cancer of the oropharynx, colon, rectum, lung, bladder, kidney, malignant melanoma, and nonmelanoma skin cancer. In women, midblood pressure was not related to total incident cancer but was positively related to cancer of the liver, pancreas, cervix, uterine corpus, and malignant melanoma. A positive association was also found for cancer mortality, with HRs per 10-mm Hg increment of 1.12 (95% CI: 1.08-1.15) for men and 1.06 (95% CI: 1.02-1.11) for women. These results suggest a small increased cancer risk overall in men with elevated blood pressure level and a higher risk for cancer death in men and women.},
  author       = {Stocks, Tanja and Van Hemelrijck, Mieke and Manjer, Jonas and Bjørge, Tone and Ulmer, Hanno and Hallmans, Göran and Lindkvist, Björn and Selmer, Randi and Nagel, Gabriele and Tretli, Steinar and Concin, Hans and Engeland, Anders and Jonsson, Håkan and Stattin, Pär},
  issn         = {1524-4563},
  language     = {eng},
  number       = {4},
  pages        = {135--802},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Hypertension},
  title        = {Blood Pressure and Risk of Cancer Incidence and Mortality in the Metabolic Syndrome and Cancer Project.},
  url          = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.189258},
  volume       = {59},
  year         = {2012},
}