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Functional Studies of microRNAs in Neural Stem Cells: Problems and Perspectives.

Åkerblom, Malin LU ; Sachdeva, Rohit LU and Jakobsson, Johan LU (2012) In Frontiers in Neuroscience 6.
Abstract
In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9, and let-7. In addition, we highlight technical strategies used to... (More)
In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9, and let-7. In addition, we highlight technical strategies used to investigate miRNA function, accentuating limitations, and potentials. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Frontiers in Neuroscience
volume
6
publisher
Frontiers
external identifiers
  • pmid:22347160
  • scopus:84862157083
ISSN
1662-4548
DOI
10.3389/fnins.2012.00014
language
English
LU publication?
yes
id
b499794b-3acd-477a-b341-ff705684631f (old id 2366701)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22347160?dopt=Abstract
date added to LUP
2012-03-02 12:34:36
date last changed
2017-11-05 04:06:33
@article{b499794b-3acd-477a-b341-ff705684631f,
  abstract     = {In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9, and let-7. In addition, we highlight technical strategies used to investigate miRNA function, accentuating limitations, and potentials.},
  articleno    = {14},
  author       = {Åkerblom, Malin and Sachdeva, Rohit and Jakobsson, Johan},
  issn         = {1662-4548},
  language     = {eng},
  publisher    = {Frontiers},
  series       = {Frontiers in Neuroscience},
  title        = {Functional Studies of microRNAs in Neural Stem Cells: Problems and Perspectives.},
  url          = {http://dx.doi.org/10.3389/fnins.2012.00014},
  volume       = {6},
  year         = {2012},
}