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In diabetic eyes, multifocal ERG reflects differences in function between the nasal part and the temporal part of the macula.

Holm, Kristina LU and Lövestam Adrian, Monica LU (2012) In Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 250(8). p.1143-1148
Abstract
PURPOSE: The purpose of the present study was to compare retinal function between the perifoveal nasal and perifoveal temporal areas of diabetic eyes using multifocalERG (mfERG).



METHODS: We included 36 eyes from 27 patients with diabetes (age 58 ± 14 years; duration of diabetes 13 ± 9 years; HbA(1c) 7.1 ± 1.8%) and a control group with 18 eyes from 18 healthy subjects (age 57 ± 11 years). Retinal thickness was assessed with optical coherence tomography (OCT) in the perifoveal areas corresponding to the summed nasal and temporal inner and outer areas. MfERG amplitude and implicit time were recorded from corresponding areas.



RESULTS: Diabetic eyes showed lower mfERG amplitude in the nasal area than in... (More)
PURPOSE: The purpose of the present study was to compare retinal function between the perifoveal nasal and perifoveal temporal areas of diabetic eyes using multifocalERG (mfERG).



METHODS: We included 36 eyes from 27 patients with diabetes (age 58 ± 14 years; duration of diabetes 13 ± 9 years; HbA(1c) 7.1 ± 1.8%) and a control group with 18 eyes from 18 healthy subjects (age 57 ± 11 years). Retinal thickness was assessed with optical coherence tomography (OCT) in the perifoveal areas corresponding to the summed nasal and temporal inner and outer areas. MfERG amplitude and implicit time were recorded from corresponding areas.



RESULTS: Diabetic eyes showed lower mfERG amplitude in the nasal area than in the temporal area (14 ± 6 vs 17 ± 7 nV/deg(2); p < 0.0001) and longer implicit time (31 ± 3 vs 30 ± 3 ms; p = 0.005). In the control group, there were no significant differences between the two areas.



CONCLUSION: Diabetic eyes showed lower amplitude and longer implicit time in the nasal area than in the temporal, which might indicate that the nasal area is more vulnerable. These findings may be of importance for evaluation of diabetic maculopathy and outcome after laser treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
volume
250
issue
8
pages
1143 - 1148
publisher
Springer
external identifiers
  • wos:000306791700004
  • pmid:22331146
  • scopus:84866432279
ISSN
1435-702X
DOI
10.1007/s00417-012-1937-4
language
English
LU publication?
yes
id
15ff02ca-e373-495f-8ef7-9fb286d06e6d (old id 2366950)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22331146?dopt=Abstract
date added to LUP
2012-03-02 11:31:39
date last changed
2017-09-10 04:49:19
@article{15ff02ca-e373-495f-8ef7-9fb286d06e6d,
  abstract     = {PURPOSE: The purpose of the present study was to compare retinal function between the perifoveal nasal and perifoveal temporal areas of diabetic eyes using multifocalERG (mfERG). <br/><br>
<br/><br>
METHODS: We included 36 eyes from 27 patients with diabetes (age 58 ± 14 years; duration of diabetes 13 ± 9 years; HbA(1c) 7.1 ± 1.8%) and a control group with 18 eyes from 18 healthy subjects (age 57 ± 11 years). Retinal thickness was assessed with optical coherence tomography (OCT) in the perifoveal areas corresponding to the summed nasal and temporal inner and outer areas. MfERG amplitude and implicit time were recorded from corresponding areas. <br/><br>
<br/><br>
RESULTS: Diabetic eyes showed lower mfERG amplitude in the nasal area than in the temporal area (14 ± 6 vs 17 ± 7 nV/deg(2); p &lt; 0.0001) and longer implicit time (31 ± 3 vs 30 ± 3 ms; p = 0.005). In the control group, there were no significant differences between the two areas. <br/><br>
<br/><br>
CONCLUSION: Diabetic eyes showed lower amplitude and longer implicit time in the nasal area than in the temporal, which might indicate that the nasal area is more vulnerable. These findings may be of importance for evaluation of diabetic maculopathy and outcome after laser treatment.},
  author       = {Holm, Kristina and Lövestam Adrian, Monica},
  issn         = {1435-702X},
  language     = {eng},
  number       = {8},
  pages        = {1143--1148},
  publisher    = {Springer},
  series       = {Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie},
  title        = {In diabetic eyes, multifocal ERG reflects differences in function between the nasal part and the temporal part of the macula.},
  url          = {http://dx.doi.org/10.1007/s00417-012-1937-4},
  volume       = {250},
  year         = {2012},
}