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Lateral asymmetry and reduced forward masking effect in early brainstem auditory evoked responses in schizophrenia.

Källstrand, Johan; Nehlstedt, Sara Fristedt; Sköld, Mia Ling and Nielzén, Sören LU (2012) In Psychiatry Research 196(2-3). p.188-193
Abstract
Individuals diagnosed with schizophrenia show deficiencies of basic neurophysiological sorting mechanisms. This study further investigated this issue, focusing on the two phenomena laterality of coding and auditory forward masking. A specific audiometric method for use in psychiatry was the measuring set up to register brain stem audiograms (ABRs). A sample of 49 schizophrenic patients was compared with three control groups consisting of healthy reference subjects (n=49), attention deficit hyperactivity disorder (ADHD) patients (n=29), Asperger syndrome (AS) patients (n=13) and drug-induced psychotic patients (n=14). Schizophrenic patients showed significant abnormal laterality of brainstem activity in wave II of the auditory brainstem... (More)
Individuals diagnosed with schizophrenia show deficiencies of basic neurophysiological sorting mechanisms. This study further investigated this issue, focusing on the two phenomena laterality of coding and auditory forward masking. A specific audiometric method for use in psychiatry was the measuring set up to register brain stem audiograms (ABRs). A sample of 49 schizophrenic patients was compared with three control groups consisting of healthy reference subjects (n=49), attention deficit hyperactivity disorder (ADHD) patients (n=29), Asperger syndrome (AS) patients (n=13) and drug-induced psychotic patients (n=14). Schizophrenic patients showed significant abnormal laterality of brainstem activity in wave II of the auditory brainstem response (ABR) in comparison with all other study groups. Forward masking effects in the superior olive complex (SOC) were coded significantly differently by schizophrenic patients compared to control groups except for the AS group. The results suggest deficits in the coding of auditory stimuli in the lower parts of the auditory pathway in schizophrenia and indicate that increased peripheral lateral asymmetry and forward masking aberrances could be neurophysiological markers for the disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Psychiatry Research
volume
196
issue
2-3
pages
188 - 193
publisher
Elsevier
external identifiers
  • wos:000305548600004
  • pmid:22326876
  • scopus:84861456932
ISSN
1872-7123
DOI
10.1016/j.psychres.2011.08.024
language
English
LU publication?
yes
id
8900a5b9-97ad-49ae-b004-55ee0f8ec633 (old id 2367017)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22326876?dopt=Abstract
date added to LUP
2012-03-02 11:02:59
date last changed
2017-05-28 04:32:37
@article{8900a5b9-97ad-49ae-b004-55ee0f8ec633,
  abstract     = {Individuals diagnosed with schizophrenia show deficiencies of basic neurophysiological sorting mechanisms. This study further investigated this issue, focusing on the two phenomena laterality of coding and auditory forward masking. A specific audiometric method for use in psychiatry was the measuring set up to register brain stem audiograms (ABRs). A sample of 49 schizophrenic patients was compared with three control groups consisting of healthy reference subjects (n=49), attention deficit hyperactivity disorder (ADHD) patients (n=29), Asperger syndrome (AS) patients (n=13) and drug-induced psychotic patients (n=14). Schizophrenic patients showed significant abnormal laterality of brainstem activity in wave II of the auditory brainstem response (ABR) in comparison with all other study groups. Forward masking effects in the superior olive complex (SOC) were coded significantly differently by schizophrenic patients compared to control groups except for the AS group. The results suggest deficits in the coding of auditory stimuli in the lower parts of the auditory pathway in schizophrenia and indicate that increased peripheral lateral asymmetry and forward masking aberrances could be neurophysiological markers for the disease.},
  author       = {Källstrand, Johan and Nehlstedt, Sara Fristedt and Sköld, Mia Ling and Nielzén, Sören},
  issn         = {1872-7123},
  language     = {eng},
  number       = {2-3},
  pages        = {188--193},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {Lateral asymmetry and reduced forward masking effect in early brainstem auditory evoked responses in schizophrenia.},
  url          = {http://dx.doi.org/10.1016/j.psychres.2011.08.024},
  volume       = {196},
  year         = {2012},
}