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A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test.

Svedman, Cecilia LU ; Engfeldt, Malin LU ; Api, Anne Marie; Politano, Valerie T; Belsito, Donald V; Isaksson, Marléne LU and Bruze, Magnus LU (2012) In Contact Dermatitis 66(3). p.137-139
Abstract
Background. Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers. Objective. Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT. Materials. 5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT. Conclusion. In patients sensitized to eugenol, with the maximum allowed concentration of... (More)
Background. Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers. Objective. Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT. Materials. 5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT. Conclusion. In patients sensitized to eugenol, with the maximum allowed concentration of eugenol and given a prolonged ROAT (4 weeks), there is a clear risk of elicitating an allergic contact dermatitis. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Contact Dermatitis
volume
66
issue
3
pages
137 - 139
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000300045700005
  • pmid:22320668
  • scopus:84856908173
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2011.02041.x
language
English
LU publication?
yes
id
811cdc3e-38a4-4c23-9c0e-4febee5d8f66 (old id 2367106)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22320668?dopt=Abstract
date added to LUP
2012-03-02 10:37:05
date last changed
2017-01-01 07:38:28
@article{811cdc3e-38a4-4c23-9c0e-4febee5d8f66,
  abstract     = {Background. Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers. Objective. Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT. Materials. 5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT. Conclusion. In patients sensitized to eugenol, with the maximum allowed concentration of eugenol and given a prolonged ROAT (4 weeks), there is a clear risk of elicitating an allergic contact dermatitis.},
  author       = {Svedman, Cecilia and Engfeldt, Malin and Api, Anne Marie and Politano, Valerie T and Belsito, Donald V and Isaksson, Marléne and Bruze, Magnus},
  issn         = {0105-1873},
  language     = {eng},
  number       = {3},
  pages        = {137--139},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test.},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2011.02041.x},
  volume       = {66},
  year         = {2012},
}