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Patch test concentrations (doses in mg/cm(2) ) for the 12 non-mix fragrance substances regulated by European legislation.

Bruze, Magnus LU ; Svedman, Cecilia LU ; Andersen, Klaus Ejner; Bruynzeel, Derk; Goossens, An; Johansen, Jeanne Duus; Matura, Mihaly; Orton, David and Vigan, Martine (2012) In Contact Dermatitis 66(3). p.131-136
Abstract
Background. According to EU legislation, 26 fragrance substance allergens must be labelled on cosmetic products. For 12 of them, the optimal patch test concentration/dose has not been evaluated. Objectives. To establish the optimal patch test doses in mg/cm(2) for the 12 fragrance substances that are not included in fragrance mix I or II in the European baseline patch test series. Materials and Methods. Patch testing with the 12 fragrance substances was performed in a stepwise manner encompassing up to five rounds in at least 100 dermatitis patients for each round. Before patch testing, an individual maximum concentration/dose was determined for each fragrance substance. Results. The predetermined maximum patch test concentrations/doses... (More)
Background. According to EU legislation, 26 fragrance substance allergens must be labelled on cosmetic products. For 12 of them, the optimal patch test concentration/dose has not been evaluated. Objectives. To establish the optimal patch test doses in mg/cm(2) for the 12 fragrance substances that are not included in fragrance mix I or II in the European baseline patch test series. Materials and Methods. Patch testing with the 12 fragrance substances was performed in a stepwise manner encompassing up to five rounds in at least 100 dermatitis patients for each round. Before patch testing, an individual maximum concentration/dose was determined for each fragrance substance. Results. The predetermined maximum patch test concentrations/doses could be tested for all 12 fragrance substances, with no observable adverse reactions being noted. Conclusions. For each fragrance substance investigated, it is recommended that half of the maximum patch test dose (mg/cm(2) ) be used for aimed and screening patch testing. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adverse reaction, active sensitization, allergic contact dermatitis, contact allergy, fragrance substance, skin irritation
in
Contact Dermatitis
volume
66
issue
3
pages
131 - 136
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000300045700004
  • pmid:22320667
  • scopus:84856882705
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2011.02037.x
language
English
LU publication?
yes
id
81d52c49-e52c-42c9-9cae-d614de71de36 (old id 2367116)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22320667?dopt=Abstract
date added to LUP
2012-03-02 10:39:12
date last changed
2017-09-10 03:08:22
@article{81d52c49-e52c-42c9-9cae-d614de71de36,
  abstract     = {Background. According to EU legislation, 26 fragrance substance allergens must be labelled on cosmetic products. For 12 of them, the optimal patch test concentration/dose has not been evaluated. Objectives. To establish the optimal patch test doses in mg/cm(2) for the 12 fragrance substances that are not included in fragrance mix I or II in the European baseline patch test series. Materials and Methods. Patch testing with the 12 fragrance substances was performed in a stepwise manner encompassing up to five rounds in at least 100 dermatitis patients for each round. Before patch testing, an individual maximum concentration/dose was determined for each fragrance substance. Results. The predetermined maximum patch test concentrations/doses could be tested for all 12 fragrance substances, with no observable adverse reactions being noted. Conclusions. For each fragrance substance investigated, it is recommended that half of the maximum patch test dose (mg/cm(2) ) be used for aimed and screening patch testing.},
  author       = {Bruze, Magnus and Svedman, Cecilia and Andersen, Klaus Ejner and Bruynzeel, Derk and Goossens, An and Johansen, Jeanne Duus and Matura, Mihaly and Orton, David and Vigan, Martine},
  issn         = {0105-1873},
  keyword      = {adverse reaction,active sensitization,allergic contact dermatitis,contact allergy,fragrance substance,skin irritation},
  language     = {eng},
  number       = {3},
  pages        = {131--136},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Patch test concentrations (doses in mg/cm(2) ) for the 12 non-mix fragrance substances regulated by European legislation.},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2011.02037.x},
  volume       = {66},
  year         = {2012},
}