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Fast metabolite mapping in the pig heart after injection of hyperpolarized (13) C-pyruvate with low-flip angle balanced steady-state free precession imaging.

Månsson, Sven LU ; Petersson, J Stefan and Scheffler, Klaus (2012) In Magnetic Resonance in Medicine 68(6). p.1894-1899
Abstract
The conversion of hyperpolarized (13) C pyruvate to metabolic products in the Krebs cycle provides valuable information about the metabolic status and the viability of the myocardium. Therefore, imaging methods must be able to spectrally discriminate different (13) C metabolites. However, the requirement for spectral selectivity conflicts with the demands for rapid image acquisition and high spatial resolution in cardiac imaging. In this work, the feasibility of a balanced steady state free precession sequence with low flip angles was investigated in the pig heart after injection of hyperpolarized (13) C(1) -pyruvate. Using cardiac gating, it was possible to acquire (13) C-bicarbonate images within a single heartbeat (acquisition time 150... (More)
The conversion of hyperpolarized (13) C pyruvate to metabolic products in the Krebs cycle provides valuable information about the metabolic status and the viability of the myocardium. Therefore, imaging methods must be able to spectrally discriminate different (13) C metabolites. However, the requirement for spectral selectivity conflicts with the demands for rapid image acquisition and high spatial resolution in cardiac imaging. In this work, the feasibility of a balanced steady state free precession sequence with low flip angles was investigated in the pig heart after injection of hyperpolarized (13) C(1) -pyruvate. Using cardiac gating, it was possible to acquire (13) C-bicarbonate images within a single heartbeat (acquisition time 150 ms) without destroying the substrate signal from the hyperpolarized pyruvate. Therefore, the technique may be useful in dynamic studies of cardiac metabolism. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
13C pyruvate, hyperpolarized 13C, balanced SSFP, spectral selectivity, metabolite mapping
in
Magnetic Resonance in Medicine
volume
68
issue
6
pages
1894 - 1899
publisher
Wiley Online Library
external identifiers
  • wos:000311398600023
  • pmid:22294528
  • scopus:84870052802
ISSN
1522-2594
DOI
10.1002/mrm.24183
language
English
LU publication?
yes
id
e79c6db7-7c50-4189-b09e-90462eff299f (old id 2367491)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22294528?dopt=Abstract
date added to LUP
2012-03-02 07:52:44
date last changed
2017-08-27 03:25:38
@article{e79c6db7-7c50-4189-b09e-90462eff299f,
  abstract     = {The conversion of hyperpolarized (13) C pyruvate to metabolic products in the Krebs cycle provides valuable information about the metabolic status and the viability of the myocardium. Therefore, imaging methods must be able to spectrally discriminate different (13) C metabolites. However, the requirement for spectral selectivity conflicts with the demands for rapid image acquisition and high spatial resolution in cardiac imaging. In this work, the feasibility of a balanced steady state free precession sequence with low flip angles was investigated in the pig heart after injection of hyperpolarized (13) C(1) -pyruvate. Using cardiac gating, it was possible to acquire (13) C-bicarbonate images within a single heartbeat (acquisition time 150 ms) without destroying the substrate signal from the hyperpolarized pyruvate. Therefore, the technique may be useful in dynamic studies of cardiac metabolism. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.},
  author       = {Månsson, Sven and Petersson, J Stefan and Scheffler, Klaus},
  issn         = {1522-2594},
  keyword      = {13C pyruvate,hyperpolarized 13C,balanced SSFP,spectral selectivity,metabolite mapping},
  language     = {eng},
  number       = {6},
  pages        = {1894--1899},
  publisher    = {Wiley Online Library},
  series       = {Magnetic Resonance in Medicine},
  title        = {Fast metabolite mapping in the pig heart after injection of hyperpolarized (13) C-pyruvate with low-flip angle balanced steady-state free precession imaging.},
  url          = {http://dx.doi.org/10.1002/mrm.24183},
  volume       = {68},
  year         = {2012},
}