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Analysis of ten candidate genes in autism by association and linkage

Philippe, Anne; Guilloud-Bataille, Michel; Martinez, Maria; Gillberg, Christopher; Råstam, Maria LU ; Sponheim, Eili; Coleman, Mary; Zappella, Michele; Aschauer, Harald and Penet, Christiane, et al. (2002) In American Journal of Medical Genetics 114(2). p.125-128
Abstract
We studied the possible involvement of ten candidate genes in autism: proenkephalin, prodynorphin, and proprotein convertase subtilisin/kexin type 2 (opioid metabolism); tyrosine hydroxylase, dopamine receptors D2 and D5, monoamine oxidases A and B (monoaminergic system); brain-derived neurotrophic factor, and neural cell adhesion molecule (involved in neurodevelopment). Thirty-eight families with two affected siblings and one family with two affected half-siblings, recruited by the Paris Autism Research International Sibpair Study (PARIS), were tested using the transmission disequilibrium test and two-point affected sib-pair linkage analysis. We found no evidence for association or linkage with intragenic or linked markers. Our family... (More)
We studied the possible involvement of ten candidate genes in autism: proenkephalin, prodynorphin, and proprotein convertase subtilisin/kexin type 2 (opioid metabolism); tyrosine hydroxylase, dopamine receptors D2 and D5, monoamine oxidases A and B (monoaminergic system); brain-derived neurotrophic factor, and neural cell adhesion molecule (involved in neurodevelopment). Thirty-eight families with two affected siblings and one family with two affected half-siblings, recruited by the Paris Autism Research International Sibpair Study (PARIS), were tested using the transmission disequilibrium test and two-point affected sib-pair linkage analysis. We found no evidence for association or linkage with intragenic or linked markers. Our family sample has good power for detecting a linkage disequilibrium of 0.80. Thus, these genes are unlikely to play a major role in the families studied, but further studies in a much larger sample would be needed to highlight weaker genetic effects. (Less)
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type
Contribution to journal
publication status
published
subject
keywords
autism, linkage disequilibrium, linkage, sib-pair
in
American Journal of Medical Genetics
volume
114
issue
2
pages
125 - 128
publisher
John Wiley & Sons
external identifiers
  • scopus:3042746413
ISSN
0148-7299
DOI
10.1002/ajmg.10041
language
English
LU publication?
no
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d55ee681-7815-4656-a4ab-247572c8835d (old id 2372783)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/11857571
http://onlinelibrary.wiley.com/doi/10.1002/ajmg.10041/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+on+11+May+from+10%3A00-12%3A00+BST+(05%3A00-07%3A00+EDT)+for+essential+maintenance
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2013-05-07 15:43:46
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2017-01-01 08:01:32
@article{d55ee681-7815-4656-a4ab-247572c8835d,
  abstract     = {We studied the possible involvement of ten candidate genes in autism: proenkephalin, prodynorphin, and proprotein convertase subtilisin/kexin type 2 (opioid metabolism); tyrosine hydroxylase, dopamine receptors D2 and D5, monoamine oxidases A and B (monoaminergic system); brain-derived neurotrophic factor, and neural cell adhesion molecule (involved in neurodevelopment). Thirty-eight families with two affected siblings and one family with two affected half-siblings, recruited by the Paris Autism Research International Sibpair Study (PARIS), were tested using the transmission disequilibrium test and two-point affected sib-pair linkage analysis. We found no evidence for association or linkage with intragenic or linked markers. Our family sample has good power for detecting a linkage disequilibrium of 0.80. Thus, these genes are unlikely to play a major role in the families studied, but further studies in a much larger sample would be needed to highlight weaker genetic effects.},
  author       = {Philippe, Anne and Guilloud-Bataille, Michel and Martinez, Maria and Gillberg, Christopher and Råstam, Maria and Sponheim, Eili and Coleman, Mary and Zappella, Michele and Aschauer, Harald and Penet, Christiane and Feingold, Josué and Brice, Alexis and Leboyer, Marion},
  issn         = {0148-7299},
  keyword      = {autism,linkage disequilibrium,linkage,sib-pair},
  language     = {eng},
  number       = {2},
  pages        = {125--128},
  publisher    = {John Wiley & Sons},
  series       = {American Journal of Medical Genetics},
  title        = {Analysis of ten candidate genes in autism by association and linkage},
  url          = {http://dx.doi.org/10.1002/ajmg.10041},
  volume       = {114},
  year         = {2002},
}