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Genome-wide scan for autism susceptibility genes. Paris Autism Research International Sibpair Study

Philippe, Anne; Martinez, Maria; Guilloud-Bataille, Michel; Gillberg, Christopher; Råstam, Maria LU ; Sponheim, Eili; Coleman, Mary; Zappella, Michele; Aschauer, Harald and Van Maldergem, Lionel, et al. (1999) In Human Molecular Genetics 8(5). p.805-812
Abstract
Family and twin studies have suggested a genetic component in autism. We performed a genome-wide screen with 264 microsatellites markers in 51 multiplex families, using non-parametric linkage methods. Families were recruited by a collaborative group including clinicians from Sweden, France, Norway, the USA, Italy, Austria and Belgium. Using two-point and multipoint affected sib-pair analyses, 11 regions gave nominal P -values of 0.05 or lower. Four of these regions overlapped with regions on chromosomes 2q, 7q, 16p and 19p identified by the first genome-wide scan of autism performed by the International Molecular Genetic Study of Autism Consortium. Another of our potential susceptibility regions overlapped with the 15q11-q13 region... (More)
Family and twin studies have suggested a genetic component in autism. We performed a genome-wide screen with 264 microsatellites markers in 51 multiplex families, using non-parametric linkage methods. Families were recruited by a collaborative group including clinicians from Sweden, France, Norway, the USA, Italy, Austria and Belgium. Using two-point and multipoint affected sib-pair analyses, 11 regions gave nominal P -values of 0.05 or lower. Four of these regions overlapped with regions on chromosomes 2q, 7q, 16p and 19p identified by the first genome-wide scan of autism performed by the International Molecular Genetic Study of Autism Consortium. Another of our potential susceptibility regions overlapped with the 15q11-q13 region identified in previous candidate gene studies. Our study revealed six additional regions on chromosomes 4q, 5p, 6q, 10q, 18q and Xp. We found that the most significant multipoint linkage was close to marker D6S283 (maximum lod score = 2.23, P = 0.0013). (Less)
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published
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Human Molecular Genetics
volume
8
issue
5
pages
805 - 812
publisher
Oxford University Press
ISSN
0964-6906
DOI
10.1093/hmg/8.5.805
language
English
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no
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caf23e80-0d13-46ea-a3e3-b4f2f16f5309 (old id 2373115)
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http://www.ncbi.nlm.nih.gov/pubmed/10196369
http://hmg.oxfordjournals.org/content/8/5/805.long
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2013-05-07 15:35:14
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2016-06-29 09:14:56
@article{caf23e80-0d13-46ea-a3e3-b4f2f16f5309,
  abstract     = {Family and twin studies have suggested a genetic component in autism. We performed a genome-wide screen with 264 microsatellites markers in 51 multiplex families, using non-parametric linkage methods. Families were recruited by a collaborative group including clinicians from Sweden, France, Norway, the USA, Italy, Austria and Belgium. Using two-point and multipoint affected sib-pair analyses, 11 regions gave nominal P -values of 0.05 or lower. Four of these regions overlapped with regions on chromosomes 2q, 7q, 16p and 19p identified by the first genome-wide scan of autism performed by the International Molecular Genetic Study of Autism Consortium. Another of our potential susceptibility regions overlapped with the 15q11-q13 region identified in previous candidate gene studies. Our study revealed six additional regions on chromosomes 4q, 5p, 6q, 10q, 18q and Xp. We found that the most significant multipoint linkage was close to marker D6S283 (maximum lod score = 2.23, P = 0.0013).},
  author       = {Philippe, Anne and Martinez, Maria and Guilloud-Bataille, Michel and Gillberg, Christopher and Råstam, Maria and Sponheim, Eili and Coleman, Mary and Zappella, Michele and Aschauer, Harald and Van Maldergem, Lionel and Penet, Christiane and Feingold, Josué and Brice, Alexis and Leboyer, Marion},
  issn         = {0964-6906},
  language     = {eng},
  number       = {5},
  pages        = {805--812},
  publisher    = {Oxford University Press},
  series       = {Human Molecular Genetics},
  title        = {Genome-wide scan for autism susceptibility genes. Paris Autism Research International Sibpair Study},
  url          = {http://dx.doi.org/10.1093/hmg/8.5.805},
  volume       = {8},
  year         = {1999},
}