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Light triggered release of solutes from covalent DNA gels

Costa, Diana; Valente, Artur J. M.; Graca Miguel, M. and Lindman, Björn LU (2011) In Colloids and Surfaces A: Physicochemical and Engineering Aspects 391(1-3). p.80-87
Abstract
DNA gels were prepared by cross-linking and were examined with respect to the release of DNA as well as macromolecular cosolutes introduced into the gels. In particular the effect of exposure to ultraviolet light was examined for these photodegradable gels. Different cross-linker densities (0.5%, 1%, 3% and 5% ethylene glycol diglycidyl ether) of the DNA gels were used. Network mesh size and the extent of swelling during degradation have been determined to characterize the effect of radiation on hydrogel degradation kinetics and simultaneous changes in gel structure on solute release profile. Modelling release kinetics, using the Weibull function, can describe the DNA release pattern, which is dependent on both radiation wavelength and... (More)
DNA gels were prepared by cross-linking and were examined with respect to the release of DNA as well as macromolecular cosolutes introduced into the gels. In particular the effect of exposure to ultraviolet light was examined for these photodegradable gels. Different cross-linker densities (0.5%, 1%, 3% and 5% ethylene glycol diglycidyl ether) of the DNA gels were used. Network mesh size and the extent of swelling during degradation have been determined to characterize the effect of radiation on hydrogel degradation kinetics and simultaneous changes in gel structure on solute release profile. Modelling release kinetics, using the Weibull function, can describe the DNA release pattern, which is dependent on both radiation wavelength and cross-linker concentration; the mechanism of desorption is found to be complex. The kinetics release of cosolutes (lysozyme, BSA and FITC-dextran), initially loaded on DNA gels, were studied and clear differences on the release pattern were obtained. From the cosolute mechanism release it can be inferred that not only effective size plays an important role, but also interaction with the DNA network. (C) 2011 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DNA gels, Drug release, Photodegradation
in
Colloids and Surfaces A: Physicochemical and Engineering Aspects
volume
391
issue
1-3
pages
80 - 87
publisher
Elsevier
external identifiers
  • wos:000299068100011
  • scopus:82355168875
ISSN
0927-7757
DOI
10.1016/j.colsurfa.2011.03.046
language
English
LU publication?
yes
id
007c66a9-9485-4228-b78a-78e6386750c5 (old id 2378643)
date added to LUP
2012-03-27 14:48:44
date last changed
2017-06-04 04:05:19
@article{007c66a9-9485-4228-b78a-78e6386750c5,
  abstract     = {DNA gels were prepared by cross-linking and were examined with respect to the release of DNA as well as macromolecular cosolutes introduced into the gels. In particular the effect of exposure to ultraviolet light was examined for these photodegradable gels. Different cross-linker densities (0.5%, 1%, 3% and 5% ethylene glycol diglycidyl ether) of the DNA gels were used. Network mesh size and the extent of swelling during degradation have been determined to characterize the effect of radiation on hydrogel degradation kinetics and simultaneous changes in gel structure on solute release profile. Modelling release kinetics, using the Weibull function, can describe the DNA release pattern, which is dependent on both radiation wavelength and cross-linker concentration; the mechanism of desorption is found to be complex. The kinetics release of cosolutes (lysozyme, BSA and FITC-dextran), initially loaded on DNA gels, were studied and clear differences on the release pattern were obtained. From the cosolute mechanism release it can be inferred that not only effective size plays an important role, but also interaction with the DNA network. (C) 2011 Elsevier B.V. All rights reserved.},
  author       = {Costa, Diana and Valente, Artur J. M. and Graca Miguel, M. and Lindman, Björn},
  issn         = {0927-7757},
  keyword      = {DNA gels,Drug release,Photodegradation},
  language     = {eng},
  number       = {1-3},
  pages        = {80--87},
  publisher    = {Elsevier},
  series       = {Colloids and Surfaces A: Physicochemical and Engineering Aspects},
  title        = {Light triggered release of solutes from covalent DNA gels},
  url          = {http://dx.doi.org/10.1016/j.colsurfa.2011.03.046},
  volume       = {391},
  year         = {2011},
}