Association between vitamin d status and non-alcoholic fatty liver disease : A population-based study
Liu, Shiying ; Liu, Yuxiu ; Wan, Bo ; Zhang, Haoyang LU
; Wu, Sumei
; Zhu, Zheng
; Lin, Yanjie
; Wang, Mingfang
; Zhang, Nanwen
and Lin, Su
, et al.
(2019)
In Journal of Nutritional Science and Vitaminology
65(4).
p.303-308
- Abstract
The relationship between vitamin D levels and non-alcoholic fatty liver disease (NAFLD remains unestablished. In this study, we aimed to explore the relationship between vitamin D levels and NAFLD based on population survey data. This cross-sectional study was conducted based on data from the National Health and Nutrition Examination Survey. Liver steatosis was diagnosed by ultrasonography. Binary logistic regression analyses were performed to determine the relationship between vitamin D status and NAFLD. A total of 9,782 participants were identified in this analysis, with 46.8% male and an average age of 44.41±0.16 y old. Among them, 6,047 (61.8% cases were without NAFLD, 1,357 (13.9% had mild NAFLD, 1,594 (16.3% had moderate and 784... (More)
The relationship between vitamin D levels and non-alcoholic fatty liver disease (NAFLD remains unestablished. In this study, we aimed to explore the relationship between vitamin D levels and NAFLD based on population survey data. This cross-sectional study was conducted based on data from the National Health and Nutrition Examination Survey. Liver steatosis was diagnosed by ultrasonography. Binary logistic regression analyses were performed to determine the relationship between vitamin D status and NAFLD. A total of 9,782 participants were identified in this analysis, with 46.8% male and an average age of 44.41±0.16 y old. Among them, 6,047 (61.8% cases were without NAFLD, 1,357 (13.9% had mild NAFLD, 1,594 (16.3% had moderate and 784 (8.0% had severe NAFLD. Compared to those with non-NAFLD or mild NAFLD, patients in the moderate to severe NAFLD group had higher vitamin D deficiency or insufficiency rates (12.4% vs 11.5% and 36.8% vs 33.2%, respectively). After adjustment for male gender, older age, race, BMI, history of diabetes and vitamin D intake, vitamin D levels were independentlyQWW associated with the severity of NAFLD (vitamin D deficiency group OR: 1.314, 95% CI: 1.129 to 1.529, vitamin D insufficiency group OR: 1.203, 95% CI: 1.090 to 1.328). Besides that, cold season was also found to be an independent factor for NAFLD (OR: 0.896, 95% CI: 0.820 to 0.979). Lower vitamin D level is an independent risk factor for NAFLD. Vitamin D levels are inversely associated with the severity of NAFLD. Cold season increases the risk of NAFLD independently.
(Less)
- author
- Liu, Shiying
; Liu, Yuxiu
; Wan, Bo
; Zhang, Haoyang
LU
; Wu, Sumei
; Zhu, Zheng
; Lin, Yanjie
; Wang, Mingfang
; Zhang, Nanwen
and Lin, Su
, et al. (More)
- Liu, Shiying
; Liu, Yuxiu
; Wan, Bo
; Zhang, Haoyang
LU
; Wu, Sumei
; Zhu, Zheng
; Lin, Yanjie
; Wang, Mingfang
; Zhang, Nanwen
; Lin, Su
and Zhu, Yueyong
(Less)
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- keywords
- Cold season, NHANES, Non-alcoholic fatty liver disease, Ultrasonography, Vitamin D
- in
- Journal of Nutritional Science and Vitaminology
- volume
- 65
- issue
- 4
- pages
- 303 - 308
- publisher
- Center for Academic Publications Japan
- external identifiers
-
- pmid:31474679
- scopus:85071739174
- ISSN
- 0301-4800
- DOI
- 10.3177/jnsv.65.303
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2019, Center for Academic Publications Japan. All rights reserved.
- id
- 237fd759-3cad-4994-9cd9-85ee189703d6
- date added to LUP
- 2024-02-05 16:06:36
- date last changed
- 2024-04-23 16:03:15
@article{237fd759-3cad-4994-9cd9-85ee189703d6,
abstract = {{<p>The relationship between vitamin D levels and non-alcoholic fatty liver disease (NAFLD remains unestablished. In this study, we aimed to explore the relationship between vitamin D levels and NAFLD based on population survey data. This cross-sectional study was conducted based on data from the National Health and Nutrition Examination Survey. Liver steatosis was diagnosed by ultrasonography. Binary logistic regression analyses were performed to determine the relationship between vitamin D status and NAFLD. A total of 9,782 participants were identified in this analysis, with 46.8% male and an average age of 44.41±0.16 y old. Among them, 6,047 (61.8% cases were without NAFLD, 1,357 (13.9% had mild NAFLD, 1,594 (16.3% had moderate and 784 (8.0% had severe NAFLD. Compared to those with non-NAFLD or mild NAFLD, patients in the moderate to severe NAFLD group had higher vitamin D deficiency or insufficiency rates (12.4% vs 11.5% and 36.8% vs 33.2%, respectively). After adjustment for male gender, older age, race, BMI, history of diabetes and vitamin D intake, vitamin D levels were independentlyQWW associated with the severity of NAFLD (vitamin D deficiency group OR: 1.314, 95% CI: 1.129 to 1.529, vitamin D insufficiency group OR: 1.203, 95% CI: 1.090 to 1.328). Besides that, cold season was also found to be an independent factor for NAFLD (OR: 0.896, 95% CI: 0.820 to 0.979). Lower vitamin D level is an independent risk factor for NAFLD. Vitamin D levels are inversely associated with the severity of NAFLD. Cold season increases the risk of NAFLD independently.</p>}},
author = {{Liu, Shiying and Liu, Yuxiu and Wan, Bo and Zhang, Haoyang and Wu, Sumei and Zhu, Zheng and Lin, Yanjie and Wang, Mingfang and Zhang, Nanwen and Lin, Su and Zhu, Yueyong}},
issn = {{0301-4800}},
keywords = {{Cold season; NHANES; Non-alcoholic fatty liver disease; Ultrasonography; Vitamin D}},
language = {{eng}},
number = {{4}},
pages = {{303--308}},
publisher = {{Center for Academic Publications Japan}},
series = {{Journal of Nutritional Science and Vitaminology}},
title = {{Association between vitamin d status and non-alcoholic fatty liver disease : A population-based study}},
url = {{http://dx.doi.org/10.3177/jnsv.65.303}},
doi = {{10.3177/jnsv.65.303}},
volume = {{65}},
year = {{2019}},
}