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Leukocyte Telomere Length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's Disease: A pilot study

Moverare-Skrtic, Sofia; Johansson, Per LU ; Mattsson, Niklas; Hansson, Oskar LU ; Wallin, Anders; Johansson, Jan-Ove; Zetterberg, Henrik; Blennow, Kaj and Svensson, Johan (2012) In Experimental Gerontology 47(2). p.179-182
Abstract
Leukocyte telomere length (LTL) is associated with the aging process and may be related to cognitive aging. Previous studies have shown conflicting results whether LTL is affected in patients with Alzheimer's disease (AD). In this pilot study, we investigated LTL in a well-defined homogeneous mono-center population. Sixty consecutive patients admitted for cognitive impairment to a memory clinic were recruited. The participants included patients with AD or mild cognitive impairment (MCI) diagnosed with AD upon follow-up (n=32), patients with stable MCI (n=13), patients with other dementias diagnosed at primary evaluation or upon follow-up (n=15), and healthy controls (n=20). LTL was determined using a quantitative PCR assay. Patients with... (More)
Leukocyte telomere length (LTL) is associated with the aging process and may be related to cognitive aging. Previous studies have shown conflicting results whether LTL is affected in patients with Alzheimer's disease (AD). In this pilot study, we investigated LTL in a well-defined homogeneous mono-center population. Sixty consecutive patients admitted for cognitive impairment to a memory clinic were recruited. The participants included patients with AD or mild cognitive impairment (MCI) diagnosed with AD upon follow-up (n=32), patients with stable MCI (n=13), patients with other dementias diagnosed at primary evaluation or upon follow-up (n=15), and healthy controls (n=20). LTL was determined using a quantitative PCR assay. Patients with AD had similar LTL as healthy controls. Patients with stable MCI had reduced LTL both compared to AD patients (p=0.02) and controls (p=0.008). Subanalyses within the AD group showed that patients with MCI that later converted to AD had similar LTL as patients with clinical diagnosis of AD at primary evaluation and healthy controls whereas the LTL was longer compared to the stable MCI group (p=0.02). There were no correlations between LTL and the core AD biomarkers A beta(1-42), T-tau and P-tau. In conclusion, in this pilot study, patients with AD or MCI that later converted to AD had similar LTL as healthy controls. Patients with stable MCI that did not progress to dementia had reduced LTL compared to controls, which might suggest a more marked biological aging as a cause of the cognitive symptoms in this group. (C) 2011 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Leukocyte telomere length, Biological aging, Alzheimer's disease, Mild, cognitive impairment, Cerebrospinal fluid
in
Experimental Gerontology
volume
47
issue
2
pages
179 - 182
publisher
Elsevier
external identifiers
  • wos:000300918500009
  • scopus:84856218257
ISSN
1873-6815
DOI
10.1016/j.exger.2011.12.005
language
English
LU publication?
yes
id
81248ae0-a348-4641-ba3b-a86deb4c2682 (old id 2384487)
date added to LUP
2012-04-02 09:23:11
date last changed
2017-10-01 03:09:02
@article{81248ae0-a348-4641-ba3b-a86deb4c2682,
  abstract     = {Leukocyte telomere length (LTL) is associated with the aging process and may be related to cognitive aging. Previous studies have shown conflicting results whether LTL is affected in patients with Alzheimer's disease (AD). In this pilot study, we investigated LTL in a well-defined homogeneous mono-center population. Sixty consecutive patients admitted for cognitive impairment to a memory clinic were recruited. The participants included patients with AD or mild cognitive impairment (MCI) diagnosed with AD upon follow-up (n=32), patients with stable MCI (n=13), patients with other dementias diagnosed at primary evaluation or upon follow-up (n=15), and healthy controls (n=20). LTL was determined using a quantitative PCR assay. Patients with AD had similar LTL as healthy controls. Patients with stable MCI had reduced LTL both compared to AD patients (p=0.02) and controls (p=0.008). Subanalyses within the AD group showed that patients with MCI that later converted to AD had similar LTL as patients with clinical diagnosis of AD at primary evaluation and healthy controls whereas the LTL was longer compared to the stable MCI group (p=0.02). There were no correlations between LTL and the core AD biomarkers A beta(1-42), T-tau and P-tau. In conclusion, in this pilot study, patients with AD or MCI that later converted to AD had similar LTL as healthy controls. Patients with stable MCI that did not progress to dementia had reduced LTL compared to controls, which might suggest a more marked biological aging as a cause of the cognitive symptoms in this group. (C) 2011 Elsevier Inc. All rights reserved.},
  author       = {Moverare-Skrtic, Sofia and Johansson, Per and Mattsson, Niklas and Hansson, Oskar and Wallin, Anders and Johansson, Jan-Ove and Zetterberg, Henrik and Blennow, Kaj and Svensson, Johan},
  issn         = {1873-6815},
  keyword      = {Leukocyte telomere length,Biological aging,Alzheimer's disease,Mild,cognitive impairment,Cerebrospinal fluid},
  language     = {eng},
  number       = {2},
  pages        = {179--182},
  publisher    = {Elsevier},
  series       = {Experimental Gerontology},
  title        = {Leukocyte Telomere Length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's Disease: A pilot study},
  url          = {http://dx.doi.org/10.1016/j.exger.2011.12.005},
  volume       = {47},
  year         = {2012},
}