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Neural cell adhesion molecule-deficient beta-cell tumorigenesis results in diminished extracellular matrix molecule expression and tumour cell-matrix adhesion

Hakansson, J; Xian, Xiaojie LU ; He, LQ; Stahlberg, A; Nelander, S; Samuelsson, T; Kubista, M and Semb, Henrik LU (2005) In Tumor Biology 26(2). p.103-112
Abstract
To understand by which mechanism neural cell adhesion molecule (N-CAM) limits tumour cell disaggregation and dissemination, we searched for potential downstream genes of N-CAM during tumour cell progression by gene expression profiling. Here, we show that N-CAM- deficient - cell tumorigenesis is associated with changes in the expression of genes involved in cell-matrix adhesion and cytoskeletal dynamics, biological processes known to affect the invasive and metastatic behaviour of tumour cells. The extracellular matrix (ECM) molecules emerged as the primary target, i.e. NCAM deficiency resulted in down-regulated mRNA expression of a broad range of ECM molecules. Consistent with this result, deficient deposition of major ECM stromal... (More)
To understand by which mechanism neural cell adhesion molecule (N-CAM) limits tumour cell disaggregation and dissemination, we searched for potential downstream genes of N-CAM during tumour cell progression by gene expression profiling. Here, we show that N-CAM- deficient - cell tumorigenesis is associated with changes in the expression of genes involved in cell-matrix adhesion and cytoskeletal dynamics, biological processes known to affect the invasive and metastatic behaviour of tumour cells. The extracellular matrix (ECM) molecules emerged as the primary target, i.e. NCAM deficiency resulted in down-regulated mRNA expression of a broad range of ECM molecules. Consistent with this result, deficient deposition of major ECM stromal components, such as fibronectin, laminin 1 and collagen IV, was observed. Moreover, N-CAM- deficient tumour cells displayed defective matrix adhesion. These results offer a potential mechanism for tumour cell disaggregation during N-CAM-deficient tumour cell progression. Prospective consequences of these findings for the role of N-CAM in tumour cell dissemination are discussed. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
insulinoma, metastasis, neural cell adhesion molecule, cancer, cell adhesion, extracellular matrix
in
Tumor Biology
volume
26
issue
2
pages
103 - 112
publisher
Springer
external identifiers
  • wos:000229432900007
  • scopus:20444486922
ISSN
1423-0380
DOI
10.1159/000085817
language
English
LU publication?
no
id
bc4d9420-53fb-4b25-b75c-2fa7ec4295fd (old id 238884)
date added to LUP
2007-08-20 11:47:42
date last changed
2017-01-01 07:28:11
@article{bc4d9420-53fb-4b25-b75c-2fa7ec4295fd,
  abstract     = {To understand by which mechanism neural cell adhesion molecule (N-CAM) limits tumour cell disaggregation and dissemination, we searched for potential downstream genes of N-CAM during tumour cell progression by gene expression profiling. Here, we show that N-CAM- deficient - cell tumorigenesis is associated with changes in the expression of genes involved in cell-matrix adhesion and cytoskeletal dynamics, biological processes known to affect the invasive and metastatic behaviour of tumour cells. The extracellular matrix (ECM) molecules emerged as the primary target, i.e. NCAM deficiency resulted in down-regulated mRNA expression of a broad range of ECM molecules. Consistent with this result, deficient deposition of major ECM stromal components, such as fibronectin, laminin 1 and collagen IV, was observed. Moreover, N-CAM- deficient tumour cells displayed defective matrix adhesion. These results offer a potential mechanism for tumour cell disaggregation during N-CAM-deficient tumour cell progression. Prospective consequences of these findings for the role of N-CAM in tumour cell dissemination are discussed.},
  author       = {Hakansson, J and Xian, Xiaojie and He, LQ and Stahlberg, A and Nelander, S and Samuelsson, T and Kubista, M and Semb, Henrik},
  issn         = {1423-0380},
  keyword      = {insulinoma,metastasis,neural cell adhesion molecule,cancer,cell adhesion,extracellular matrix},
  language     = {eng},
  number       = {2},
  pages        = {103--112},
  publisher    = {Springer},
  series       = {Tumor Biology},
  title        = {Neural cell adhesion molecule-deficient beta-cell tumorigenesis results in diminished extracellular matrix molecule expression and tumour cell-matrix adhesion},
  url          = {http://dx.doi.org/10.1159/000085817},
  volume       = {26},
  year         = {2005},
}