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Circulating endothelial and platelet derived microparticles reflect the size of myocardium at risk in patients with ST-elevation myocardial infarction

Jung, Christian; Sorensson, Peder; Saleh, Nawsad; Arheden, Håkan LU ; Ryden, Lars and Pernow, John (2012) In Atherosclerosis 221(1). p.226-231
Abstract
Objectives: Microparticles (MP) are small membrane vesicles, released from activated, damaged and apoptotic endothelial cells (EMP) or platelets (PMP) that may actively modulate inflammation, coagulation and vascular function. We tested the hypothesis that the number of circulating EMP or PMP in acute myocardial infarction correlates with the myocardium at risk (MaR) and infarct size (IS). Methods: EMP were quantified in plasma samples of 36 patients (age: 63 +/- 10 years) with first time ST-elevation myocardial infarction (STEMI) using flow cytometry. EMP were defined as CD31(+)/CD42(-) MP and CD144(+) MP and PMP as CD31(+)/CD42(+) MP. MaR and IS was determined by cardiovascular magnetic resonance imaging one week after the index event.... (More)
Objectives: Microparticles (MP) are small membrane vesicles, released from activated, damaged and apoptotic endothelial cells (EMP) or platelets (PMP) that may actively modulate inflammation, coagulation and vascular function. We tested the hypothesis that the number of circulating EMP or PMP in acute myocardial infarction correlates with the myocardium at risk (MaR) and infarct size (IS). Methods: EMP were quantified in plasma samples of 36 patients (age: 63 +/- 10 years) with first time ST-elevation myocardial infarction (STEMI) using flow cytometry. EMP were defined as CD31(+)/CD42(-) MP and CD144(+) MP and PMP as CD31(+)/CD42(+) MP. MaR and IS was determined by cardiovascular magnetic resonance imaging one week after the index event. Results: Plasma levels of CD31(+)/CD42(-) EMP were 251.0 +/- 178.8/mu l and CD144(+) 106.3 +/- 33.7/mu l. PMP levels were 579.2 +/- 631.8/mu l. MaR was 31.0 +/- 11.2% of the left ventricle and IS was 11.4 +/- 7.1% of the left ventricle. Patients with STEMI in the left anterior descending artery had higher levels of CD31(+)/CD42(-) EMP and PMP than those with other infarct-related arteries (p<0.05). The numbers of CD31(+)/CD42(-) EMP and PMP correlated to MaR, but not to IS. Conclusions: Circulating EMP and PMP correlate to the size of MaR in patients with STEMI suggesting that they reflect the severity of the endothelial injury and platelet activation during myocardial ischemia. (C) 2011 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Endothelial microparticles, Ischemia, Acute myocardial infarction, Hypoxia
in
Atherosclerosis
volume
221
issue
1
pages
226 - 231
publisher
Elsevier
external identifiers
  • wos:000300629500034
  • scopus:84857031342
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2011.12.025
language
English
LU publication?
yes
id
1633f4a4-f026-4df3-8423-d97dc8e9ee31 (old id 2390884)
date added to LUP
2012-04-02 09:25:36
date last changed
2017-10-29 03:12:51
@article{1633f4a4-f026-4df3-8423-d97dc8e9ee31,
  abstract     = {Objectives: Microparticles (MP) are small membrane vesicles, released from activated, damaged and apoptotic endothelial cells (EMP) or platelets (PMP) that may actively modulate inflammation, coagulation and vascular function. We tested the hypothesis that the number of circulating EMP or PMP in acute myocardial infarction correlates with the myocardium at risk (MaR) and infarct size (IS). Methods: EMP were quantified in plasma samples of 36 patients (age: 63 +/- 10 years) with first time ST-elevation myocardial infarction (STEMI) using flow cytometry. EMP were defined as CD31(+)/CD42(-) MP and CD144(+) MP and PMP as CD31(+)/CD42(+) MP. MaR and IS was determined by cardiovascular magnetic resonance imaging one week after the index event. Results: Plasma levels of CD31(+)/CD42(-) EMP were 251.0 +/- 178.8/mu l and CD144(+) 106.3 +/- 33.7/mu l. PMP levels were 579.2 +/- 631.8/mu l. MaR was 31.0 +/- 11.2% of the left ventricle and IS was 11.4 +/- 7.1% of the left ventricle. Patients with STEMI in the left anterior descending artery had higher levels of CD31(+)/CD42(-) EMP and PMP than those with other infarct-related arteries (p&lt;0.05). The numbers of CD31(+)/CD42(-) EMP and PMP correlated to MaR, but not to IS. Conclusions: Circulating EMP and PMP correlate to the size of MaR in patients with STEMI suggesting that they reflect the severity of the endothelial injury and platelet activation during myocardial ischemia. (C) 2011 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Jung, Christian and Sorensson, Peder and Saleh, Nawsad and Arheden, Håkan and Ryden, Lars and Pernow, John},
  issn         = {1879-1484},
  keyword      = {Endothelial microparticles,Ischemia,Acute myocardial infarction,Hypoxia},
  language     = {eng},
  number       = {1},
  pages        = {226--231},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Circulating endothelial and platelet derived microparticles reflect the size of myocardium at risk in patients with ST-elevation myocardial infarction},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2011.12.025},
  volume       = {221},
  year         = {2012},
}