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Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue

Nilsson, L; Binart, N; Bohlooly-Y, M; Bramnert, Margareta LU ; Egecioglu, E; Kindblom, J; Kelly, PA; Kopchick, JJ; Ormandy, CJ and Ling, Charlotte LU , et al. (2005) In Biochemical and Biophysical Research Communications 331(4). p.1120-1126
Abstract
Adiponectin is a hormone secreted from adipose tissue, and serum levels are decreased with obesity and insulin resistance. Because prolactin (PRL) and growth hormone (GH) can affect insulin sensitivity, we investigated the effects of these hormones on the regulation of adiponectin in human adipose tissue in vitro and in rodents in vivo. Adiponectin secretion was significantly suppressed by PRL and GH in in vitro cultured human adipose tissue. Furthermore, PRL increased adiponectin receptor 1 (AdipoR1) mRNA expression and GH decreased AdipoR2 expression in the cultured human adipose tissue. In transgenic mice expressing GH, and female mice expressing PRL, serum levels of adiponectin were decreased. In contrast, GH receptor deficient mice... (More)
Adiponectin is a hormone secreted from adipose tissue, and serum levels are decreased with obesity and insulin resistance. Because prolactin (PRL) and growth hormone (GH) can affect insulin sensitivity, we investigated the effects of these hormones on the regulation of adiponectin in human adipose tissue in vitro and in rodents in vivo. Adiponectin secretion was significantly suppressed by PRL and GH in in vitro cultured human adipose tissue. Furthermore, PRL increased adiponectin receptor 1 (AdipoR1) mRNA expression and GH decreased AdipoR2 expression in the cultured human adipose tissue. In transgenic mice expressing GH, and female mice expressing PRL, serum levels of adiponectin were decreased. In contrast, GH receptor deficient mice had elevated adiponectin levels, while PRL receptor deficient mice were unaffected. In conclusion, we demonstrate gene expression of AdipoR1 and AdipoR2 in human adipose tissue for the first time, and show that these are differentially regulated by PRL and GH. Both PRL and GH reduced adiponectin secretion in human adipose tissue in vitro and in mice in vivo. Decreased serum adiponectin levels have been associated with insulin resistance, and our data in human tissue and in transgenic mice suggest a role for adiponectin in PRL and GH induced insulin resistance. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
keywords
prolactin, adiponectin, adiponectin receptor, growth hormone
in
Biochemical and Biophysical Research Communications
volume
331
issue
4
pages
1120 - 1126
publisher
Elsevier
external identifiers
  • pmid:15882993
  • wos:000229234500033
  • scopus:21044455602
ISSN
1090-2104
DOI
10.1016/j.bbrc.2005.04.026
language
English
LU publication?
yes
id
89c02a86-8da4-422a-83d4-211c90f12100 (old id 239160)
date added to LUP
2007-08-22 13:51:30
date last changed
2017-10-01 04:34:11
@article{89c02a86-8da4-422a-83d4-211c90f12100,
  abstract     = {Adiponectin is a hormone secreted from adipose tissue, and serum levels are decreased with obesity and insulin resistance. Because prolactin (PRL) and growth hormone (GH) can affect insulin sensitivity, we investigated the effects of these hormones on the regulation of adiponectin in human adipose tissue in vitro and in rodents in vivo. Adiponectin secretion was significantly suppressed by PRL and GH in in vitro cultured human adipose tissue. Furthermore, PRL increased adiponectin receptor 1 (AdipoR1) mRNA expression and GH decreased AdipoR2 expression in the cultured human adipose tissue. In transgenic mice expressing GH, and female mice expressing PRL, serum levels of adiponectin were decreased. In contrast, GH receptor deficient mice had elevated adiponectin levels, while PRL receptor deficient mice were unaffected. In conclusion, we demonstrate gene expression of AdipoR1 and AdipoR2 in human adipose tissue for the first time, and show that these are differentially regulated by PRL and GH. Both PRL and GH reduced adiponectin secretion in human adipose tissue in vitro and in mice in vivo. Decreased serum adiponectin levels have been associated with insulin resistance, and our data in human tissue and in transgenic mice suggest a role for adiponectin in PRL and GH induced insulin resistance.},
  author       = {Nilsson, L and Binart, N and Bohlooly-Y, M and Bramnert, Margareta and Egecioglu, E and Kindblom, J and Kelly, PA and Kopchick, JJ and Ormandy, CJ and Ling, Charlotte and Billig, H},
  issn         = {1090-2104},
  keyword      = {prolactin,adiponectin,adiponectin receptor,growth hormone},
  language     = {eng},
  number       = {4},
  pages        = {1120--1126},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2005.04.026},
  volume       = {331},
  year         = {2005},
}