High frequency of false-positive reactions in attempted patch testing with acrylate/methacrylate mixes.
(2012) In Contact Dermatitis 67(3). p.157-161- Abstract
- Background:
Although acrylate/methacrylate allergy has been frequently reported, until now patch testing with this group of allergens has been unwieldy, requiring the application of large supplementary series in most centres.
Objectives:
To formulate and evaluate two mixes of acrylate/methacrylate allergens in three centres (Malmö, Singapore, and Leuven).
Patients/materials/methods:
All patients tested with the baseline series during the study period were also patch tested with the mixes. Mix 1 consisted of: triethyleneglycol diacrylate (TREGDA) 0.1% wt/wt, 2-hydroxyethyl methacrylate (2-HEMA) 1.0% wt/wt and ethyleneglycol dimethacrylate 1.0% wt/wt in petrolatum. Mix 2... (More) - Background:
Although acrylate/methacrylate allergy has been frequently reported, until now patch testing with this group of allergens has been unwieldy, requiring the application of large supplementary series in most centres.
Objectives:
To formulate and evaluate two mixes of acrylate/methacrylate allergens in three centres (Malmö, Singapore, and Leuven).
Patients/materials/methods:
All patients tested with the baseline series during the study period were also patch tested with the mixes. Mix 1 consisted of: triethyleneglycol diacrylate (TREGDA) 0.1% wt/wt, 2-hydroxyethyl methacrylate (2-HEMA) 1.0% wt/wt and ethyleneglycol dimethacrylate 1.0% wt/wt in petrolatum. Mix 2 consisted of: TREGDA 0.1% wt/wt and 2-HEMA 2.0% wt/wt in pet. The separate components of the two mixes were also tested simultaneously. Results. There were 25 (5 males; 20 females) positive reactions to mix 1 with 16 in Malmö, 8 in Singapore, and 1 in Leuven. Positive reactions to mix 2 were seen only in Malmö, in 8 female patients. Thus, the positive reaction rate for mix 1 was 8.3% overall (Malmö 7.7%, Singapore 18.6%, and Leuven 2.1%), and that for mix 2 was 2.7% overall (Malmö 3.8%, Singapore 0%, and Leuven 0%). Of the 16 positive reactions to mix 1 in Malmö, only 4 were considered to be true allergic reactions, as the component allergen testing gave totally negative results in 12/16. For mix 2, only 3/8 positive reactions were considered to be true allergic reactions, as the component testing was negative in 5/8. Many doubtful (10-20%) and positive but non-allergic reactions were recorded, leading to early termination of the study.
Conclusions:
Although this was an unsuccessful attempt to formulate an acrylate/methacrylate mix, our experience will be useful for those embarking on future attempts to do this. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2608519
- author
- Goon, Anthony LU ; Bruze, Magnus LU ; Zimerson, Erik LU ; Goossens, An ; Goh, Chee-Leok and Isaksson, Marléne LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Contact Dermatitis
- volume
- 67
- issue
- 3
- pages
- 157 - 161
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000307846500006
- pmid:22624961
- scopus:84865246727
- pmid:22624961
- ISSN
- 0105-1873
- DOI
- 10.1111/j.1600-0536.2012.02106.x
- language
- English
- LU publication?
- yes
- id
- 23974221-26c4-4205-b457-0c8e3840970c (old id 2608519)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22624961?dopt=Abstract
- date added to LUP
- 2016-04-04 08:14:58
- date last changed
- 2022-06-18 17:05:22
@article{23974221-26c4-4205-b457-0c8e3840970c,
abstract = {{Background:<br/><br>
Although acrylate/methacrylate allergy has been frequently reported, until now patch testing with this group of allergens has been unwieldy, requiring the application of large supplementary series in most centres. <br/><br>
<br/><br>
Objectives:<br/><br>
To formulate and evaluate two mixes of acrylate/methacrylate allergens in three centres (Malmö, Singapore, and Leuven). <br/><br>
<br/><br>
Patients/materials/methods:<br/><br>
All patients tested with the baseline series during the study period were also patch tested with the mixes. Mix 1 consisted of: triethyleneglycol diacrylate (TREGDA) 0.1% wt/wt, 2-hydroxyethyl methacrylate (2-HEMA) 1.0% wt/wt and ethyleneglycol dimethacrylate 1.0% wt/wt in petrolatum. Mix 2 consisted of: TREGDA 0.1% wt/wt and 2-HEMA 2.0% wt/wt in pet. The separate components of the two mixes were also tested simultaneously. Results. There were 25 (5 males; 20 females) positive reactions to mix 1 with 16 in Malmö, 8 in Singapore, and 1 in Leuven. Positive reactions to mix 2 were seen only in Malmö, in 8 female patients. Thus, the positive reaction rate for mix 1 was 8.3% overall (Malmö 7.7%, Singapore 18.6%, and Leuven 2.1%), and that for mix 2 was 2.7% overall (Malmö 3.8%, Singapore 0%, and Leuven 0%). Of the 16 positive reactions to mix 1 in Malmö, only 4 were considered to be true allergic reactions, as the component allergen testing gave totally negative results in 12/16. For mix 2, only 3/8 positive reactions were considered to be true allergic reactions, as the component testing was negative in 5/8. Many doubtful (10-20%) and positive but non-allergic reactions were recorded, leading to early termination of the study. <br/><br>
<br/><br>
Conclusions:<br/><br>
Although this was an unsuccessful attempt to formulate an acrylate/methacrylate mix, our experience will be useful for those embarking on future attempts to do this.}},
author = {{Goon, Anthony and Bruze, Magnus and Zimerson, Erik and Goossens, An and Goh, Chee-Leok and Isaksson, Marléne}},
issn = {{0105-1873}},
language = {{eng}},
number = {{3}},
pages = {{157--161}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{High frequency of false-positive reactions in attempted patch testing with acrylate/methacrylate mixes.}},
url = {{http://dx.doi.org/10.1111/j.1600-0536.2012.02106.x}},
doi = {{10.1111/j.1600-0536.2012.02106.x}},
volume = {{67}},
year = {{2012}},
}